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ENZYME

ENZYME entry: EC 1.3.98.1

PURL: https://purl.expasy.org/enzyme/EC/1.3.98.1
Accepted Name
dihydroorotate oxidase (fumarate)
Alternative Name(s)
DHOD
DHODase
DHOdehase
dihydoorotic acid dehydrogenase
dihydroorotate dehydrogenase
dihydroorotate oxidase
Reaction catalysed
(S)-dihydroorotate + fumarate = orotate + succinate
Comment(s)
  • The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides.
  • Molecular oxygen can replace fumarate in vitro.
  • Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
  • Formerly EC 1.3.3.1.
Cross-references
BRENDA1.3.98.1
EC2PDB1.3.98.1
ExplorEnz1.3.98.1
KEGG Ligand Database for Enzyme Nomenclature1.3.98.1
IUBMB Enzyme Nomenclature1.3.98.1
MEDLINEFind literature relating to 1.3.98.1
MetaCyc1.3.98.1
Rhea expert-curated reactions1.3.98.1
UniProtKB/Swiss-Prot
Q7Z895, PYRD1_KLULAQ7Z892, PYRD1_LACK1Q9YFI6, PYRDA_AERPE
O66461, PYRDA_AQUAEP59626, PYRDA_ENTFAQ5FJB5, PYRDA_LACAC
Q1G864, PYRDA_LACDAQ047M3, PYRDA_LACDBA8YVZ9, PYRDA_LACH4
Q74J29, PYRDA_LACJOQ9CFC9, PYRDA_LACLAQ53ZE5, PYRDA_LACLC
A2RJT9, PYRDA_LACLMQ038Z3, PYRDA_LACP3P77887, PYRDA_LACPL
A5VHS3, PYRDA_LIMRDB2G5A3, PYRDA_LIMRJQ03HA9, PYRDA_PEDPA
Q01YA2, PYRDA_SOLUEQ3K2G4, PYRDA_STRA1Q8E6L0, PYRDA_STRA3
Q8E155, PYRDA_STRA5C0M8R7, PYRDA_STRE4Q99Z28, PYRDA_STRP1
P0DD66, PYRDA_STRP3Q8P0C0, PYRDA_STRP8A2RDV3, PYRDA_STRPG
Q9X9S0, PYRDA_STRPNP0DD67, PYRDA_STRPQQ8DQG9, PYRDA_STRR6
C0MCW6, PYRDA_STRS7B9DUS7, PYRDA_STRU0B2V726, PYRDA_SULSY
Q6V3X0, PYRD_NAUCAQ7Z894, PYRD_SACBAQ7Z893, PYRD_SACMI
Q7Z891, PYRD_SACPAQ57U83, PYRD_TRYB2Q4D3W2, PYRD_TRYCC
P28272, PYRD_YEAST

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