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ENZYME

ENZYME entry: EC 1.3.1.76

Accepted Name
precorrin-2 dehydrogenase
Alternative Name(s)
precorrin-2 oxidase
Reaction catalysed
NAD(+) + precorrin-2 <=> 2 H(+) + NADH + sirohydrochlorin
Comment(s)
  • Catalyzes the second of three steps leading to the formation of siroheme from uroporphyrinogen III.
  • The first step involves the donation of two S-adenosyl-L-methionine- derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107) and the third step involves the chelation of ferrous iron to sirohydrochlorin to form siroheme (EC 4.99.1.4).
  • In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p.
  • In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirC being responsible for the above reaction.
Cross-references
BRENDA1.3.1.76
EC2PDB1.3.1.76
ExplorEnz1.3.1.76
PRIAM enzyme-specific profiles1.3.1.76
KEGG Ligand Database for Enzyme Nomenclature1.3.1.76
IUBMB Enzyme Nomenclature1.3.1.76
IntEnz1.3.1.76
MEDLINEFind literature relating to 1.3.1.76
MetaCyc1.3.1.76
Rhea expert-curated reactions1.3.1.76
UniProtKB/Swiss-Prot
A0KLD7, CYSG1_AERHHA4SHL4, CYSG1_AERS4A7MJ67, CYSG1_CROS8
A1WWP8, CYSG1_HALHLA6TD45, CYSG1_KLEP7Q6D1A4, CYSG1_PECAS
A8G9Y3, CYSG1_SERP5A1JJS8, CYSG1_YERE8A7FLY4, CYSG1_YERP3
Q1CLS2, CYSG1_YERPNA4TGU8, CYSG1_YERPPQ66EC9, CYSG1_YERPS
A0KP37, CYSG2_AERHHA4SRH0, CYSG2_AERS4A7MKK9, CYSG2_CROS8
A1WYD5, CYSG2_HALHLA6TF07, CYSG2_KLEP7Q6CZS0, CYSG2_PECAS
A8GKQ1, CYSG2_SERP5A1JSB7, CYSG2_YERE8A7FNS9, CYSG2_YERP3
Q1CCP6, CYSG2_YERPNA4TPZ1, CYSG2_YERPPQ664M6, CYSG2_YERPS
A0KQJ4, CYSG3_AERHHQ6F8G6, CYSG_ACIADB3GZA0, CYSG_ACTP7
B0BTC2, CYSG_ACTPJA6VPZ6, CYSG_ACTSZQ0VQ05, CYSG_ALCBS
Q0A812, CYSG_ALKEHC1DKY7, CYSG_AZOVDQ1LTP4, CYSG_BAUCH
Q7VQG9, CYSG_BLOFLQ493N1, CYSG_BLOPBQ2KWB0, CYSG_BORA1
Q7WMM4, CYSG_BORBRQ7WB57, CYSG_BORPAA9HZV6, CYSG_BORPD
Q7VZ77, CYSG_BORPEP57500, CYSG_BUCAIQ7NZV7, CYSG_CHRVO
A8AQS4, CYSG_CITK8A7ZSP4, CYSG_ECO24B7UK79, CYSG_ECO27
B7MCY5, CYSG_ECO45B7L4P2, CYSG_ECO55P0AEA9, CYSG_ECO57
B5YTS6, CYSG_ECO5EB7NMD7, CYSG_ECO7IB7N1F1, CYSG_ECO81
B7M1S1, CYSG_ECO8AC4ZUM4, CYSG_ECOBWB1X716, CYSG_ECODH
A8A5H5, CYSG_ECOHSA1AGQ2, CYSG_ECOK1Q0TC92, CYSG_ECOL5
Q8FCW8, CYSG_ECOL6B1IP96, CYSG_ECOLCP0AEA8, CYSG_ECOLI
B7NDX8, CYSG_ECOLUB6I2S7, CYSG_ECOSEB1LHG9, CYSG_ECOSM
Q1R5R3, CYSG_ECOUTC5BGP8, CYSG_EDWI9A4WFH1, CYSG_ENT38
B7LS75, CYSG_ESCF3A9H259, CYSG_GLUDAQ5FP95, CYSG_GLUOX
Q2SJB7, CYSG_HAHCHQ31GG8, CYSG_HYDCUQ65T49, CYSG_MANSM
Q606C9, CYSG_METCAQ1H3L5, CYSG_METFKA9LZ77, CYSG_NEIM0
P57001, CYSG_NEIMAP95370, CYSG_NEIMBA1KU10, CYSG_NEIMF
Q0AHC1, CYSG_NITECQ820Q4, CYSG_NITEUQ2Y6L7, CYSG_NITMU
Q3JCS0, CYSG_NITOCQ7N8L2, CYSG_PHOLLQ6LM67, CYSG_PHOPR
Q48H75, CYSG_PSE14Q15YU1, CYSG_PSEA6A6V4H6, CYSG_PSEA7
B7UW11, CYSG_PSEA8Q02NA3, CYSG_PSEABQ9I0M7, CYSG_PSEAE
Q1IBC9, CYSG_PSEE4Q4K9V8, CYSG_PSEF5C3JY53, CYSG_PSEFS
A4XUX3, CYSG_PSEMYA5W1H7, CYSG_PSEP1Q3KA85, CYSG_PSEPF
Q88FT3, CYSG_PSEPKB1JBD9, CYSG_PSEPWQ87ZT0, CYSG_PSESM
Q3ILQ9, CYSG_PSET1Q4ZRL6, CYSG_PSEU2Q4FSU1, CYSG_PSYA2
Q1QAX7, CYSG_PSYCKA1SRP9, CYSG_PSYINA5WEG6, CYSG_PSYWF
A1AVU5, CYSG_RUTMCQ21K21, CYSG_SACD2B5F8J0, CYSG_SALA4
A9MME5, CYSG_SALARQ57IZ5, CYSG_SALCHB5FJQ1, CYSG_SALDC
B5R2C7, CYSG_SALEPB5R7N6, CYSG_SALG2B4TKQ4, CYSG_SALHS
B4SVI1, CYSG_SALNSQ5PLV8, CYSG_SALPAA9MT45, CYSG_SALPB
C0Q0F3, CYSG_SALPCB5BH22, CYSG_SALPKB4TY38, CYSG_SALSV
Q8Z201, CYSG_SALTIP25924, CYSG_SALTYB2U3H4, CYSG_SHIB3
Q31VS0, CYSG_SHIBSQ32AZ8, CYSG_SHIDSQ0SZU8, CYSG_SHIF8
Q83JB3, CYSG_SHIFLQ3YWQ3, CYSG_SHISSQ2NVN0, CYSG_SODGM
A4VLU6, CYSG_STUS1Q3SG32, CYSG_THIDAB8GUD3, CYSG_THISH
C4LAG5, CYSG_TOLATA5CXE4, CYSG_VESOHB2I985, CYSG_XYLF2
Q9PF46, CYSG_XYLFAB0U4X0, CYSG_XYLFMQ87AI5, CYSG_XYLFT
Q1C2P9, CYSG_YERPAQ74Y23, CYSG_YERPEQ5NRM4, CYSG_ZYMMO
Q59292, HEMA_RUMJOO14172, MET8_SCHPOP15807, MET8_YEAST
Q46CH4, PC2DH_METBFQ57605, PC2DH_METJAO34813, SIRC_BACSU
P61818, SIRC_PRIMG

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-