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ENZYME

ENZYME entry: EC 4.99.1.4

Accepted Name
sirohydrochlorin ferrochelatase
Reaction catalysed
2 H(+) + siroheme <=> Fe(2+) + sirohydrochlorin
Comment(s)
  • This enzyme catalyzes the third of three steps leading to the formation of siroheme from uroporphyrinogen III.
  • The first step involves the donation of two S-adenosyl-L-methionine- derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107) and the second step involves an NAD(+)-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76).
  • In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p.
  • In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirB being responsible for the above reaction.
Cross-references
BRENDA4.99.1.4
EC2PDB4.99.1.4
ExplorEnz4.99.1.4
PRIAM enzyme-specific profiles4.99.1.4
KEGG Ligand Database for Enzyme Nomenclature4.99.1.4
IUBMB Enzyme Nomenclature4.99.1.4
IntEnz4.99.1.4
MEDLINEFind literature relating to 4.99.1.4
MetaCyc4.99.1.4
Rhea expert-curated reactions4.99.1.4
UniProtKB/Swiss-Prot
Q72CB8, CBIKC_DESVHQ72EC8, CBIKP_DESVHA0KLD7, CYSG1_AERHH
A4SHL4, CYSG1_AERS4A7MJ67, CYSG1_CROS8A1WWP8, CYSG1_HALHL
A6TD45, CYSG1_KLEP7Q6D1A4, CYSG1_PECASA8G9Y3, CYSG1_SERP5
A1JJS8, CYSG1_YERE8A7FLY4, CYSG1_YERP3Q1CLS2, CYSG1_YERPN
A4TGU8, CYSG1_YERPPQ66EC9, CYSG1_YERPSA0KP37, CYSG2_AERHH
A4SRH0, CYSG2_AERS4A7MKK9, CYSG2_CROS8A1WYD5, CYSG2_HALHL
A6TF07, CYSG2_KLEP7Q6CZS0, CYSG2_PECASA8GKQ1, CYSG2_SERP5
A1JSB7, CYSG2_YERE8A7FNS9, CYSG2_YERP3Q1CCP6, CYSG2_YERPN
A4TPZ1, CYSG2_YERPPQ664M6, CYSG2_YERPSA0KQJ4, CYSG3_AERHH
Q6F8G6, CYSG_ACIADB3GZA0, CYSG_ACTP7B0BTC2, CYSG_ACTPJ
A6VPZ6, CYSG_ACTSZQ0VQ05, CYSG_ALCBSQ0A812, CYSG_ALKEH
C1DKY7, CYSG_AZOVDQ1LTP4, CYSG_BAUCHQ7VQG9, CYSG_BLOFL
Q493N1, CYSG_BLOPBQ2KWB0, CYSG_BORA1Q7WMM4, CYSG_BORBR
Q7WB57, CYSG_BORPAA9HZV6, CYSG_BORPDQ7VZ77, CYSG_BORPE
P57500, CYSG_BUCAIQ7NZV7, CYSG_CHRVOA8AQS4, CYSG_CITK8
A7ZSP4, CYSG_ECO24B7UK79, CYSG_ECO27B7MCY5, CYSG_ECO45
B7L4P2, CYSG_ECO55P0AEA9, CYSG_ECO57B5YTS6, CYSG_ECO5E
B7NMD7, CYSG_ECO7IB7N1F1, CYSG_ECO81B7M1S1, CYSG_ECO8A
C4ZUM4, CYSG_ECOBWB1X716, CYSG_ECODHA8A5H5, CYSG_ECOHS
A1AGQ2, CYSG_ECOK1Q0TC92, CYSG_ECOL5Q8FCW8, CYSG_ECOL6
B1IP96, CYSG_ECOLCP0AEA8, CYSG_ECOLIB7NDX8, CYSG_ECOLU
B6I2S7, CYSG_ECOSEB1LHG9, CYSG_ECOSMQ1R5R3, CYSG_ECOUT
C5BGP8, CYSG_EDWI9A4WFH1, CYSG_ENT38B7LS75, CYSG_ESCF3
A9H259, CYSG_GLUDAQ5FP95, CYSG_GLUOXQ2SJB7, CYSG_HAHCH
Q31GG8, CYSG_HYDCUQ65T49, CYSG_MANSMQ606C9, CYSG_METCA
Q1H3L5, CYSG_METFKA9LZ77, CYSG_NEIM0P57001, CYSG_NEIMA
P95370, CYSG_NEIMBA1KU10, CYSG_NEIMFQ0AHC1, CYSG_NITEC
Q820Q4, CYSG_NITEUQ2Y6L7, CYSG_NITMUQ3JCS0, CYSG_NITOC
Q7N8L2, CYSG_PHOLLQ6LM67, CYSG_PHOPRQ48H75, CYSG_PSE14
Q15YU1, CYSG_PSEA6A6V4H6, CYSG_PSEA7B7UW11, CYSG_PSEA8
Q02NA3, CYSG_PSEABQ9I0M7, CYSG_PSEAEQ1IBC9, CYSG_PSEE4
Q4K9V8, CYSG_PSEF5C3JY53, CYSG_PSEFSA4XUX3, CYSG_PSEMY
A5W1H7, CYSG_PSEP1Q3KA85, CYSG_PSEPFQ88FT3, CYSG_PSEPK
B1JBD9, CYSG_PSEPWQ87ZT0, CYSG_PSESMQ3ILQ9, CYSG_PSET1
Q4ZRL6, CYSG_PSEU2Q4FSU1, CYSG_PSYA2Q1QAX7, CYSG_PSYCK
A1SRP9, CYSG_PSYINA5WEG6, CYSG_PSYWFA1AVU5, CYSG_RUTMC
Q21K21, CYSG_SACD2B5F8J0, CYSG_SALA4A9MME5, CYSG_SALAR
Q57IZ5, CYSG_SALCHB5FJQ1, CYSG_SALDCB5R2C7, CYSG_SALEP
B5R7N6, CYSG_SALG2B4TKQ4, CYSG_SALHSB4SVI1, CYSG_SALNS
Q5PLV8, CYSG_SALPAA9MT45, CYSG_SALPBC0Q0F3, CYSG_SALPC
B5BH22, CYSG_SALPKB4TY38, CYSG_SALSVQ8Z201, CYSG_SALTI
P25924, CYSG_SALTYB2U3H4, CYSG_SHIB3Q31VS0, CYSG_SHIBS
Q32AZ8, CYSG_SHIDSQ0SZU8, CYSG_SHIF8Q83JB3, CYSG_SHIFL
Q3YWQ3, CYSG_SHISSQ2NVN0, CYSG_SODGMA4VLU6, CYSG_STUS1
Q3SG32, CYSG_THIDAB8GUD3, CYSG_THISHC4LAG5, CYSG_TOLAT
A5CXE4, CYSG_VESOHB2I985, CYSG_XYLF2Q9PF46, CYSG_XYLFA
B0U4X0, CYSG_XYLFMQ87AI5, CYSG_XYLFTQ1C2P9, CYSG_YERPA
Q74Y23, CYSG_YERPEQ5NRM4, CYSG_ZYMMOQ59292, HEMA_RUMJO
O14172, MET8_SCHPOP15807, MET8_YEASTQ84JH7, SIRB_ARATH
O34632, SIRB_BACSUP61817, SIRB_PRIMG

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.99.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.99.-.-
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