Expasy logo

ENZYME

ENZYME entry: EC 2.1.1.107

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.107
Accepted Name
uroporphyrinogen-III C-methyltransferase
Alternative Name(s)
adenosylmethionine-uroporphyrinogen III methyltransferase
S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase
SUMT
urogen III methylase
uroporphyrin-III C-methyltransferase
uroporphyrinogen III methylase
uroporphyrinogen-III methylase
uroporphyrinogen-III methyltransferase
uroporphyrinogen methyltransferase
Reaction catalysed
uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • This enzyme catalyzes two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2.
  • It is the first of three steps leading to the formation of siroheme from uroporphyrinogen III.
  • The second step involves an NAD(+)-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76) and the third step involves the chelation of Fe(2+) to sirohydrochlorin to form siroheme (EC 4.99.1.4).
  • In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p.
  • In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirA being responsible for the above reaction.
  • Also involved in the biosynthesis of cobalamin.
Cross-references
BRENDA2.1.1.107
EC2PDB2.1.1.107
ExplorEnz2.1.1.107
KEGG Ligand Database for Enzyme Nomenclature2.1.1.107
IUBMB Enzyme Nomenclature2.1.1.107
MEDLINEFind literature relating to 2.1.1.107
MetaCyc2.1.1.107
Rhea expert-curated reactions2.1.1.107
UniProtKB/Swiss-Prot
A0KLD7, CYSG1_AERHHA4SHL4, CYSG1_AERS4A7MJ67, CYSG1_CROS8
A1WWP8, CYSG1_HALHLA6TD45, CYSG1_KLEP7Q6D1A4, CYSG1_PECAS
A8G9Y3, CYSG1_SERP5A1JJS8, CYSG1_YERE8A7FLY4, CYSG1_YERP3
Q1CLS2, CYSG1_YERPNA4TGU8, CYSG1_YERPPQ66EC9, CYSG1_YERPS
A0KP37, CYSG2_AERHHA4SRH0, CYSG2_AERS4A7MKK9, CYSG2_CROS8
A1WYD5, CYSG2_HALHLA6TF07, CYSG2_KLEP7Q6CZS0, CYSG2_PECAS
A8GKQ1, CYSG2_SERP5A1JSB7, CYSG2_YERE8A7FNS9, CYSG2_YERP3
Q1CCP6, CYSG2_YERPNA4TPZ1, CYSG2_YERPPQ664M6, CYSG2_YERPS
A0KQJ4, CYSG3_AERHHQ6F8G6, CYSG_ACIADB3GZA0, CYSG_ACTP7
B0BTC2, CYSG_ACTPJA6VPZ6, CYSG_ACTSZQ0VQ05, CYSG_ALCBS
Q0A812, CYSG_ALKEHC1DKY7, CYSG_AZOVDQ1LTP4, CYSG_BAUCH
Q7VQG9, CYSG_BLOFLQ493N1, CYSG_BLOPBQ2KWB0, CYSG_BORA1
Q7WMM4, CYSG_BORBRQ7WB57, CYSG_BORPAA9HZV6, CYSG_BORPD
Q7VZ77, CYSG_BORPEP57500, CYSG_BUCAIQ7NZV7, CYSG_CHRVO
A8AQS4, CYSG_CITK8A7ZSP4, CYSG_ECO24B7UK79, CYSG_ECO27
B7MCY5, CYSG_ECO45B7L4P2, CYSG_ECO55P0AEA9, CYSG_ECO57
B5YTS6, CYSG_ECO5EB7NMD7, CYSG_ECO7IB7N1F1, CYSG_ECO81
B7M1S1, CYSG_ECO8AC4ZUM4, CYSG_ECOBWB1X716, CYSG_ECODH
A8A5H5, CYSG_ECOHSA1AGQ2, CYSG_ECOK1Q0TC92, CYSG_ECOL5
Q8FCW8, CYSG_ECOL6B1IP96, CYSG_ECOLCP0AEA8, CYSG_ECOLI
B7NDX8, CYSG_ECOLUB6I2S7, CYSG_ECOSEB1LHG9, CYSG_ECOSM
Q1R5R3, CYSG_ECOUTA4XUX3, CYSG_ECTM1C5BGP8, CYSG_EDWI9
A4WFH1, CYSG_ENT38B7LS75, CYSG_ESCF3A9H259, CYSG_GLUDA
Q5FP95, CYSG_GLUOXQ2SJB7, CYSG_HAHCHQ31GG8, CYSG_HYDCU
Q65T49, CYSG_MANSMQ606C9, CYSG_METCAQ1H3L5, CYSG_METFK
A9LZ77, CYSG_NEIM0P57001, CYSG_NEIMAP95370, CYSG_NEIMB
A1KU10, CYSG_NEIMFQ0AHC1, CYSG_NITECQ820Q4, CYSG_NITEU
Q2Y6L7, CYSG_NITMUQ3JCS0, CYSG_NITOCQ7N8L2, CYSG_PHOLL
Q6LM67, CYSG_PHOPRQ48H75, CYSG_PSE14Q15YU1, CYSG_PSEA6
B7UW11, CYSG_PSEA8Q02NA3, CYSG_PSEABQ9I0M7, CYSG_PSEAE
Q1IBC9, CYSG_PSEE4Q4K9V8, CYSG_PSEF5C3JY53, CYSG_PSEFS
A5W1H7, CYSG_PSEP1A6V4H6, CYSG_PSEP7Q3KA85, CYSG_PSEPF
Q88FT3, CYSG_PSEPKB1JBD9, CYSG_PSEPWQ87ZT0, CYSG_PSESM
Q3ILQ9, CYSG_PSET1Q4ZRL6, CYSG_PSEU2Q4FSU1, CYSG_PSYA2
Q1QAX7, CYSG_PSYCKA1SRP9, CYSG_PSYINA5WEG6, CYSG_PSYWF
A1AVU5, CYSG_RUTMCQ21K21, CYSG_SACD2B5F8J0, CYSG_SALA4
A9MME5, CYSG_SALARQ57IZ5, CYSG_SALCHB5FJQ1, CYSG_SALDC
B5R2C7, CYSG_SALEPB5R7N6, CYSG_SALG2B4TKQ4, CYSG_SALHS
B4SVI1, CYSG_SALNSQ5PLV8, CYSG_SALPAA9MT45, CYSG_SALPB
C0Q0F3, CYSG_SALPCB5BH22, CYSG_SALPKB4TY38, CYSG_SALSV
Q8Z201, CYSG_SALTIP25924, CYSG_SALTYB2U3H4, CYSG_SHIB3
Q31VS0, CYSG_SHIBSQ32AZ8, CYSG_SHIDSQ0SZU8, CYSG_SHIF8
Q83JB3, CYSG_SHIFLQ3YWQ3, CYSG_SHISSQ2NVN0, CYSG_SODGM
A4VLU6, CYSG_STUS1Q3SG32, CYSG_THIDAB8GUD3, CYSG_THISH
C4LAG5, CYSG_TOLATA5CXE4, CYSG_VESOHB2I985, CYSG_XYLF2
Q9PF46, CYSG_XYLFAB0U4X0, CYSG_XYLFMQ87AI5, CYSG_XYLFT
Q1C2P9, CYSG_YERPAQ74Y23, CYSG_YERPEQ5NRM4, CYSG_ZYMMO
Q59294, HEM4_RUMJOP42437, NASF_BACSUQ51701, NIRE_PARDP
O34744, SUMT_BACSUO19889, SUMT_CYACAQ46BL0, SUMT_METBF
P29564, SUMT_METIVQ58375, SUMT_METJAP29928, SUMT_PRIMG
Q9I2W4, SUMT_PSEAEP37725, SUMT_PSEFLO74468, SUMT_SCHPO
P21631, SUMT_SINSXP42451, SUMT_SYNE7Q55749, SUMT_SYNY3
P36150, SUMT_YEASTQ42606, UPM1_ARATH

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-