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ENZYME entry: EC 1.4.3.22

Accepted Name
diamine oxidase.
Alternative Name(s)
amine oxidase.
amine oxidase (copper-containing).
CAO.
copper amine oxidase.
Cu-containing amine oxidase.
diamino oxhydrase.
histaminase.
histamine deaminase.
semicarbazide-sensitive amine oxidase.
SSAO.
Reaction catalysed
H2O + histamine + O2 <=> H2O2 + imidazole-4-acetaldehyde + NH4(+)
Comment(s)
  • A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity toward secondary and tertiary amines.
  • They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 but unlike EC 1.4.3.4, they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.
  • Formerly EC 1.4.3.6.
Cross-references
BRENDA1.4.3.22
EC2PDB1.4.3.22
ExplorEnz1.4.3.22
PRIAM enzyme-specific profiles1.4.3.22
KEGG Ligand Database for Enzyme Nomenclature1.4.3.22
IUBMB Enzyme Nomenclature1.4.3.22
IntEnz1.4.3.22
MEDLINEFind literature relating to 1.4.3.22
MetaCyc1.4.3.22
Rhea expert-curated reactions1.4.3.22
UniProtKB/Swiss-Prot
Q12556, AMO1_ASPNG;  Q59118, AMOH_ARTGO;  P19801, AOC1_HUMAN;  
Q8JZQ5, AOC1_MOUSE;  Q9TRC7, AOC1_PIG;  P36633, AOC1_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-