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ENZYME entry: EC

Accepted Name
pteridine reductase.
Alternative Name(s)
pteridine reductase 1.
Reaction catalysed
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 2 H(+) + L-erythro-biopterin + 2 NADPH
  • The enzyme from Leishmania (both amastigote and promastigote forms) catalyzes the NADPH-dependent reduction of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms.
  • It also catalyzes the reduction of 7,8-dihydropterins and 7,8- dihydrofolate to their tetrahydro forms.
  • In contrast to EC and EC, pteridine reductase will not catalyze the reduction of the quinonoid form of dihydrobiopterin.
  • The enzyme is specific for NADPH; no activity has been detected with NADH.
  • It also differs from EC in being specific for the B side of NADPH.
  • Formerly EC
PRIAM enzyme-specific profiles1.5.1.33
KEGG Ligand Database for Enzyme Nomenclature1.5.1.33
IUBMB Enzyme Nomenclature1.5.1.33
MEDLINEFind literature relating to
Rhea expert-curated reactions1.5.1.33
Q01782, PTR1_LEIMA;  P42556, PTR1_LEITA;  

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