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ENZYME entry: EC 1.5.1.33

Accepted Name
pteridine reductase.
Alternative Name(s)
pteridine reductase 1.
PTR1.
Reaction catalysed
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) <=> 2 H(+) + L-erythro-biopterin + 2 NADPH
Comment(s)
  • The enzyme from Leishmania (both amastigote and promastigote forms) catalyzes the NADPH-dependent reduction of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms.
  • It also catalyzes the reduction of 7,8-dihydropterins and 7,8- dihydrofolate to their tetrahydro forms.
  • In contrast to EC 1.5.1.3 and EC 1.5.1.34, pteridine reductase will not catalyze the reduction of the quinonoid form of dihydrobiopterin.
  • The enzyme is specific for NADPH; no activity has been detected with NADH.
  • It also differs from EC 1.5.1.3 in being specific for the B side of NADPH.
  • Formerly EC 1.1.1.253.
Cross-references
BRENDA1.5.1.33
EC2PDB1.5.1.33
ExplorEnz1.5.1.33
PRIAM enzyme-specific profiles1.5.1.33
KEGG Ligand Database for Enzyme Nomenclature1.5.1.33
IUBMB Enzyme Nomenclature1.5.1.33
IntEnz1.5.1.33
MEDLINEFind literature relating to 1.5.1.33
MetaCyc1.5.1.33
Rhea expert-curated reactions1.5.1.33
UniProtKB/Swiss-Prot
Q01782, PTR1_LEIMA;  P42556, PTR1_LEITA;  

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