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ENZYME entry: EC 1.5.3.10

Accepted Name
dimethylglycine oxidase.
Reaction catalysed
(6S)-5,6,7,8-tetrahydrofolate + N,N-dimethylglycine + O2 <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H2O2 + sarcosine
Comment(s)
  • A flavoprotein (FAD).
  • The enzyme, characterized from the bacterium Arthrobacter globiformis, contains two active sites connected by a large 'reaction chamber'.
  • An imine intermediate is transferred between the sites, eliminating the production of toxic formaldehyde.
  • In the absence of folate the enzyme does form formaldehyde.
  • Does not oxidize sarcosine.
  • cf. EC 1.5.8.4.
Cross-references
BRENDA1.5.3.10
EC2PDB1.5.3.10
ExplorEnz1.5.3.10
PRIAM enzyme-specific profiles1.5.3.10
KEGG Ligand Database for Enzyme Nomenclature1.5.3.10
IUBMB Enzyme Nomenclature1.5.3.10
IntEnz1.5.3.10
MEDLINEFind literature relating to 1.5.3.10
MetaCyc1.5.3.10
Rhea expert-curated reactions1.5.3.10
UniProtKB/Swiss-Prot
Q9AGP8, DMGO_ARTGO

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