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ENZYME

ENZYME entry: EC 1.5.7.1

Accepted Name
methylenetetrahydrofolate reductase (ferredoxin)
Alternative Name(s)
5,10-methylenetetrahydrofolate reductase
Reaction catalysed
(6S)-5-methyl-5,6,7,8-tetrahydrofolate + 2 oxidized [2Fe-2S]-[ferredoxin] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
Comment(s)
  • The enzyme from Clostridium formicoaceticum catalyzes the reduction of methylene blue, menadione, benzyl viologen, rubredoxin or FAD with 5-methyltetrahydrofolate and the oxidation of reduced ferredoxin or FADH2 with 5,10-methylenetetrahydrofolate.
  • However, unlike EC 1.5.1.20, EC 1.5.1.53, or EC 1.5.1.24, there is no activity with either NADH or NADP(+).
Cross-references
BRENDA1.5.7.1
EC2PDB1.5.7.1
ExplorEnz1.5.7.1
PRIAM enzyme-specific profiles1.5.7.1
KEGG Ligand Database for Enzyme Nomenclature1.5.7.1
IUBMB Enzyme Nomenclature1.5.7.1
IntEnz1.5.7.1
MEDLINEFind literature relating to 1.5.7.1
MetaCyc1.5.7.1
Rhea expert-curated reactions1.5.7.1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-