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ENZYME entry: EC 1.5.7.1

Accepted Name
Methylenetetrahydrofolate reductase (ferredoxin).
Alternative Name(s)
5,10-methylenetetrahydrofolate reductase.
Reaction catalysed
5-methyltetrahydrofolate + 2 oxidized ferredoxin <=> 5,10-methylenetetrahydrofolate + 2 reduced ferredoxin + 2 H(+)
Cofactor(s)
Flavoprotein; Iron-sulfur; Zn(2+).
Comment(s)
  • The enzyme from Clostridium formicoaceticum catalyzes the reduction of methylene blue, menadione, benzyl viologen, rubredoxin or FAD with 5-methyltetrahydrofolate and the oxidation of reduced ferredoxin or FADH(2) with 5,10-methylenetetrahydrofolate.
  • However, unlike EC 1.5.1.20, there is no activity with NAD(P)H.
Cross-references
BRENDA1.5.7.1
EC2PDB1.5.7.1
ExplorEnz1.5.7.1
PRIAM enzyme-specific profiles1.5.7.1
KEGG Ligand Database for Enzyme Nomenclature1.5.7.1
IUBMB Enzyme Nomenclature1.5.7.1
IntEnz1.5.7.1
MEDLINEFind literature relating to 1.5.7.1
MetaCyc1.5.7.1
Rhea expert-curated reactions1.5.7.1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-