ENZYME entry: EC 1.5.1.20
Accepted Name |
methylenetetrahydrofolate reductase [NAD(P)H].
|
Alternative Name(s) |
MTHFR. |
Reaction catalysed |
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH
|
Comment(s) |
- A flavoprotein (FAD).
- The enzyme catalyzes the reversible conversion of 5,10-
methylenetetrahydrofolate to 5-methyltetrahydrofolate, playing an
important role in folate metabolism by regulating the distribution of
one-carbon moieties between cellular methylation reactions and
nucleic acid synthesis.
- This enzyme, characterized from Protozoan parasites of the genus
Leishmania, is unique among similar characterized eukaryotic enzymes
in that it lacks the C-terminal allosteric regulatory domain
(allowing it to catalyze a reversible reaction) and uses NADH and
NADPH with equal efficiency under physiological conditions. cf.
EC 1.5.1.53, EC 1.5.1.54, and EC 1.5.7.1.
- Formerly EC 1.1.1.68, EC 1.1.1.171, EC 1.1.99.15 and EC 1.7.99.5.
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Cross-references |
BRENDA | 1.5.1.20 |
EC2PDB | 1.5.1.20 |
ExplorEnz | 1.5.1.20 |
PRIAM enzyme-specific profiles | 1.5.1.20 |
KEGG Ligand Database for Enzyme Nomenclature | 1.5.1.20 |
IUBMB Enzyme Nomenclature | 1.5.1.20 |
IntEnz | 1.5.1.20 |
MEDLINE | Find literature relating to 1.5.1.20 |
MetaCyc | 1.5.1.20 |
Rhea expert-curated reactions | 1.5.1.20 |
UniProtKB/Swiss-Prot |
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