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ENZYME entry: EC 1.5.1.20

Accepted Name
methylenetetrahydrofolate reductase [NAD(P)H].
Alternative Name(s)
MTHFR.
Reaction catalysed
  • (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH
  • (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH
Comment(s)
  • A flavoprotein (FAD).
  • The enzyme catalyzes the reversible conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, playing an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis.
  • This enzyme, characterized from Protozoan parasites of the genus Leishmania, is unique among similar characterized eukaryotic enzymes in that it lacks the C-terminal allosteric regulatory domain (allowing it to catalyze a reversible reaction) and uses NADH and NADPH with equal efficiency under physiological conditions. cf. EC 1.5.1.53, EC 1.5.1.54, and EC 1.5.7.1.
  • Formerly EC 1.1.1.68, EC 1.1.1.171, EC 1.1.99.15 and EC 1.7.99.5.
Cross-references
BRENDA1.5.1.20
EC2PDB1.5.1.20
ExplorEnz1.5.1.20
PRIAM enzyme-specific profiles1.5.1.20
KEGG Ligand Database for Enzyme Nomenclature1.5.1.20
IUBMB Enzyme Nomenclature1.5.1.20
IntEnz1.5.1.20
MEDLINEFind literature relating to 1.5.1.20
MetaCyc1.5.1.20
Rhea expert-curated reactions1.5.1.20
UniProtKB/Swiss-Prot
Q10258, MTHR1_SCHPO;  P46151, MTHR1_YEAST;  O06745, YITJ_BACSU;  

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