| Accepted Name |
|---|
| methylenetetrahydrofolate reductase [NAD(P)H].
|
| Alternative Name(s) |
|---|
| MTHFR. |
| Reaction catalysed |
|---|
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH
|
| Comment(s) |
|---|
- A flavoprotein (FAD).
- The enzyme catalyzes the reversible conversion of 5,10-
methylenetetrahydrofolate to 5-methyltetrahydrofolate, playing an
important role in folate metabolism by regulating the distribution of
one-carbon moieties between cellular methylation reactions and
nucleic acid synthesis.
- This enzyme, characterized from Protozoan parasites of the genus
Leishmania, is unique among similar characterized eukaryotic enzymes
in that it lacks the C-terminal allosteric regulatory domain
(allowing it to catalyze a reversible reaction) and uses NADH and
NADPH with equal efficiency under physiological conditions.
- Cf. EC 1.5.1.53, EC 1.5.1.54, and EC 1.5.7.1.
- Formerly EC 1.1.1.68, EC 1.1.1.171, EC 1.1.99.15 and EC 1.7.99.5.
|
| Cross-references |
|---|
| BRENDA | 1.5.1.20 |
| EC2PDB | 1.5.1.20 |
| ExplorEnz | 1.5.1.20 |
| PRIAM enzyme-specific profiles | 1.5.1.20 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.5.1.20 |
| IUBMB Enzyme Nomenclature | 1.5.1.20 |
| IntEnz | 1.5.1.20 |
| MEDLINE | Find literature relating to 1.5.1.20 |
| MetaCyc | 1.5.1.20 |
| Rhea expert-curated reactions | 1.5.1.20 |
| UniProtKB/Swiss-Prot |
| O67422, METF_AQUAE; | P57154, METF_BUCAI; | Q8KA62, METF_BUCAP; |
| Q89B13, METF_BUCBP; | P0AEZ1, METF_ECOLI; | P45208, METF_HAEIN; |
| Q9JZQ3, METF_NEIMB; | P71319, METF_PECCC; | P11003, METF_SALTY; |
| P0AEZ2, METF_SHIFL; | G2IQS8, METF_SPHSK; | O54235, METF_STRLI; |
| Q9SE60, MTHR1_ARATH; | Q9SE94, MTHR1_MAIZE; | Q10258, MTHR1_SCHPO; |
| P46151, MTHR1_YEAST; | O80585, MTHR2_ARATH; | O74927, MTHR2_SCHPO; |
| P53128, MTHR2_YEAST; | Q5I598, MTHR_BOVIN; | Q17693, MTHR_CAEEL; |
| P42898, MTHR_HUMAN; | Q60HE5, MTHR_MACFA; | Q9WU20, MTHR_MOUSE; |
| Q75HE6, MTHR_ORYSJ; | O06745, YITJ_BACSU; |
|