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ENZYME entry: EC 1.5.1.20

Accepted Name
Methylenetetrahydrofolate reductase (NAD(P)H).
Alternative Name(s)
MTHFR.
Reaction catalysed
5-methyltetrahydrofolate + NAD(P)(+) <=> 5,10-methylenetetrahydrofolate + NAD(P)H
Cofactor(s)
FAD.
Comment(s)
  • A flavoprotein (FAD).
  • The enzyme catalyzes the reversible conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, playing an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis.
  • This enzyme, characterized from Protozoan parasites of the genus Leishmania, is unique among similar characterized eukaryotic enzymes in that it lacks the C-terminal allosteric regulatory domain (allowing it to catalyze a reversible reaction) and uses NADH and NADPH with equal efficiency under physiological conditions.
  • Cf. EC 1.5.1.53, EC 1.5.1.54, and EC 1.5.7.1.
  • Formerly EC 1.1.1.68, EC 1.1.1.171, EC 1.1.99.15 and EC 1.7.99.5.
Cross-references
BRENDA1.5.1.20
EC2PDB1.5.1.20
ExplorEnz1.5.1.20
PRIAM enzyme-specific profiles1.5.1.20
KEGG Ligand Database for Enzyme Nomenclature1.5.1.20
IUBMB Enzyme Nomenclature1.5.1.20
IntEnz1.5.1.20
MEDLINEFind literature relating to 1.5.1.20
MetaCyc1.5.1.20
Rhea expert-curated reactions1.5.1.20
UniProtKB/Swiss-Prot
O67422, METF_AQUAE;  P57154, METF_BUCAI;  Q8KA62, METF_BUCAP;  
Q89B13, METF_BUCBP;  P0AEZ1, METF_ECOLI;  P45208, METF_HAEIN;  
Q9JZQ3, METF_NEIMB;  P71319, METF_PECCC;  P11003, METF_SALTY;  
P0AEZ2, METF_SHIFL;  G2IQS8, METF_SPHSK;  O54235, METF_STRLI;  
Q9SE60, MTHR1_ARATH;  Q9SE94, MTHR1_MAIZE;  Q10258, MTHR1_SCHPO;  
P46151, MTHR1_YEAST;  O80585, MTHR2_ARATH;  O74927, MTHR2_SCHPO;  
P53128, MTHR2_YEAST;  Q5I598, MTHR_BOVIN;  Q17693, MTHR_CAEEL;  
P42898, MTHR_HUMAN;  Q60HE5, MTHR_MACFA;  Q9WU20, MTHR_MOUSE;  
Q75HE6, MTHR_ORYSJ;  O06745, YITJ_BACSU;  

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