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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.8.1.12

Accepted Name
Trypanothione-disulfide reductase.
Alternative Name(s)
N(1),N(8)-bis(glutathionyl)spermidine reductase.
NADPH:trypanothione oxidoreductase.
Trypanothione reductase.
Reaction catalysed
Trypanothione + NADP(+) <=> trypanothione disulfide + NADPH
Cofactor(s)
FAD.
Comment(s)
  • Trypanothione disulfide is the oxidized form of N(1),N(8)- bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata.
  • The activity is dependent on a redox-active cystine at the active center (cf. EC 1.8.1.7).
  • Formerly EC 1.6.4.8.
Cross-references
PROSITEPDOC00073
BRENDA1.8.1.12
EC2PDB1.8.1.12
ExplorEnz1.8.1.12
PRIAM enzyme-specific profiles1.8.1.12
KEGG Ligand Database for Enzyme Nomenclature1.8.1.12
IUBMB Enzyme Nomenclature1.8.1.12
IntEnz1.8.1.12
MEDLINEFind literature relating to 1.8.1.12
MetaCyc1.8.1.12
UniProtKB/Swiss-Prot
P39040, TYTR_CRIFA;  P39050, TYTR_LEIDO;  P39051, TYTR_TRYBB;  
P13110, TYTR_TRYCO;  P28593, TYTR_TRYCR;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-