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ENZYME entry: EC 1.8.1.12

Accepted Name
Trypanothione-disulfide reductase.
Alternative Name(s)
N(1),N(8)-bis(glutathionyl)spermidine reductase.
NADPH:trypanothione oxidoreductase.
Trypanothione reductase.
Reaction catalysed
Trypanothione + NADP(+) <=> trypanothione disulfide + NADPH
Cofactor(s)
FAD.
Comment(s)
  • Trypanothione disulfide is the oxidized form of N(1),N(8)- bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata.
  • The activity is dependent on a redox-active cystine at the active center (cf. EC 1.8.1.7).
  • Formerly EC 1.6.4.8.
Cross-references
PROSITEPDOC00073
BRENDA1.8.1.12
EC2PDB1.8.1.12
ExplorEnz1.8.1.12
PRIAM enzyme-specific profiles1.8.1.12
KEGG Ligand Database for Enzyme Nomenclature1.8.1.12
IUBMB Enzyme Nomenclature1.8.1.12
IntEnz1.8.1.12
MEDLINEFind literature relating to 1.8.1.12
MetaCyc1.8.1.12
Rhea expert-curated reactions1.8.1.12
UniProtKB/Swiss-Prot
P39040, TYTR_CRIFA;  P39050, TYTR_LEIDO;  P39051, TYTR_TRYBB;  
P13110, TYTR_TRYCO;  P28593, TYTR_TRYCR;  

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