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ENZYME

ENZYME entry: EC 1.8.98.7

PURL: https://purl.expasy.org/enzyme/EC/1.8.98.7
Accepted Name
cysteine-type anaerobic sulfatase-maturating enzyme
Alternative Name(s)
anaerobic sulfatase maturase
Cys-type anaerobic sulfatase-maturating enzyme
Reaction catalysed
L-cysteinyl-[sulfatase] + S-adenosyl-L-methionine + H2O = 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + 5'-deoxyadenosine + L-methionine + 2 H(+)
Comment(s)
  • A radical S-adenosylmethionine (AdoMet) enzyme that contains three [4Fe-4S] clusters.
  • The enzyme, found in some bacteria, activates a type I sulfatase enzyme (EC 3.1.6.1) by converting a conserved L-cysteine residue in the active site to a unique 3-oxo-L-alanine residue that is essential for the sulfatase activity.
  • Some enzymes can also act on L-serine, see EC 1.1.98.7 and EC 1.8.3.7.
Cross-references
BRENDA1.8.98.7
EC2PDB1.8.98.7
ExplorEnz1.8.98.7
KEGG Ligand Database for Enzyme Nomenclature1.8.98.7
IUBMB Enzyme Nomenclature1.8.98.7
MEDLINEFind literature relating to 1.8.98.7
MetaCyc1.8.98.7
Rhea expert-curated reactions1.8.98.7
UniProtKB/Swiss-Prot
A0Q2E1, ANSME_CLONNQ0TTH1, ANSME_CLOP1Q8XMQ3, ANSME_CLOPE

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