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ENZYME entry: EC 3.1.6.1

Accepted Name
Arylsulfatase (type I).
Alternative Name(s)
Aryl-sulfate sulphohydrolase.
Sulfatase.
Reaction catalysed
A phenol sulfate + H(2)O <=> a phenol + sulfate
Comment(s)
  • Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors.
  • Arylsulfatases are type I enzymes, found in both prokaryotes and eukaryotes, with rather similar specificities.
  • The key catalytic residue 3-oxo-L-alanine initiates the reaction through a nucleophilic attack on the sulfur atom in the substrate.
  • This residue is generated by posttranslational modification of a conserved cysteine or serine residue by EC 1.8.3.7, EC 1.1.98.-, serine-type anaerobic sulfatase-maturating enzyme, or EC 1.8.98.-, cysteine-type anaerobic sulfatase-maturating enzyme.
Cross-references
PROSITEPDOC00117
BRENDA3.1.6.1
EC2PDB3.1.6.1
ExplorEnz3.1.6.1
PRIAM enzyme-specific profiles3.1.6.1
KEGG Ligand Database for Enzyme Nomenclature3.1.6.1
IUBMB Enzyme Nomenclature3.1.6.1
IntEnz3.1.6.1
MEDLINEFind literature relating to 3.1.6.1
MetaCyc3.1.6.1
UniProtKB/Swiss-Prot
Q32KH9, ARSG_CANLF;  Q96EG1, ARSG_HUMAN;  Q3TYD4, ARSG_MOUSE;  
Q32KJ9, ARSG_RAT;  P14217, ARS_CHLRE;  P14000, ARS_HEMPU;  
P51691, ARS_PSEAE;  P28607, ARS_PSEVC;  P50473, ARS_STRPU;  
Q10723, ARS_VOLCA;  P20713, ATSA_KLEAE;  Q9X759, ATSA_KLEPN;  
Q0TUK6, SULF_CLOP1;  Q8XNV1, SULF_CLOPE;  

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