Accepted Name |
arylsulfatase (type I)
|
Alternative Name(s) |
aryl-sulfate sulphohydrolase |
sulfatase |
Reaction catalysed |
an aryl sulfate + H2O <=> a phenol + H(+) + sulfate |
Comment(s) |
- Sulfatase enzymes are classified as type I, in which the key
catalytic residue is 3-oxo-L-alanine, type II, which are non-heme
iron-dependent dioxygenases, or type III, whose catalytic domain
adopts a metallo-beta-lactamase fold and binds two zinc ions as
cofactors.
- Arylsulfatases are type I enzymes, found in both prokaryotes and
eukaryotes, with rather similar specificities.
- The key catalytic residue 3-oxo-L-alanine initiates the reaction
through a nucleophilic attack on the sulfur atom in the substrate.
- This residue is generated by post-translational modification of a
conserved cysteine or serine residue by EC 1.8.3.7, EC 1.1.98.7,
or EC 1.8.98.7.
|
Cross-references |
BRENDA | 3.1.6.1 |
EC2PDB | 3.1.6.1 |
ExplorEnz | 3.1.6.1 |
PRIAM enzyme-specific profiles | 3.1.6.1 |
KEGG Ligand Database for Enzyme Nomenclature | 3.1.6.1 |
IUBMB Enzyme Nomenclature | 3.1.6.1 |
IntEnz | 3.1.6.1 |
MEDLINE | Find literature relating to 3.1.6.1 |
MetaCyc | 3.1.6.1 |
Rhea expert-curated reactions | 3.1.6.1 |
UniProtKB/Swiss-Prot |
P54793, ARSF_HUMAN | Q32KH9, ARSG_CANLF | Q96EG1, ARSG_HUMAN |
Q3TYD4, ARSG_MOUSE | Q32KJ9, ARSG_RAT | Q148F3, ARSK_BOVIN |
Q32KH0, ARSK_CANLF | Q5ZK90, ARSK_CHICK | Q08CJ7, ARSK_DANRE |
Q6UWY0, ARSK_HUMAN | Q9D2L1, ARSK_MOUSE | Q32KJ2, ARSK_RAT |
Q0IHJ2, ARSK_XENLA | P51690, ARSL_HUMAN | Q60HH5, ARSL_MACFA |
P14217, ARS_CHLRE | P14000, ARS_HEMPU | P51691, ARS_PSEAE |
P28607, ARS_PSEVC | P50473, ARS_STRPU | Q10723, ARS_VOLCA |
P20713, ATSA_KLEAE | Q9X759, ATSA_KLEPN | Q0TUK6, SULF_CLOP1 |
Q8XNV1, SULF_CLOPE |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.1.6.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-