| Accepted Name |
|---|
| arylsulfatase (type I)
|
| Alternative Name(s) |
|---|
| aryl-sulfate sulphohydrolase |
| sulfatase |
| Reaction catalysed |
|---|
| an aryl sulfate + H2O <=> a phenol + H(+) + sulfate |
| Comment(s) |
|---|
- Sulfatase enzymes are classified as type I, in which the key
catalytic residue is 3-oxo-L-alanine, type II, which are non-heme
iron-dependent dioxygenases, or type III, whose catalytic domain
adopts a metallo-beta-lactamase fold and binds two zinc ions as
cofactors.
- Arylsulfatases are type I enzymes, found in both prokaryotes and
eukaryotes, with rather similar specificities.
- The key catalytic residue 3-oxo-L-alanine initiates the reaction
through a nucleophilic attack on the sulfur atom in the substrate.
- This residue is generated by post-translational modification of a
conserved cysteine or serine residue by EC 1.8.3.7, EC 1.1.98.7,
or EC 1.8.98.7.
|
| Cross-references |
|---|
| BRENDA | 3.1.6.1 |
| EC2PDB | 3.1.6.1 |
| ExplorEnz | 3.1.6.1 |
| PRIAM enzyme-specific profiles | 3.1.6.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.6.1 |
| IUBMB Enzyme Nomenclature | 3.1.6.1 |
| IntEnz | 3.1.6.1 |
| MEDLINE | Find literature relating to 3.1.6.1 |
| MetaCyc | 3.1.6.1 |
| Rhea expert-curated reactions | 3.1.6.1 |
| UniProtKB/Swiss-Prot |
| P54793, ARSF_HUMAN | Q32KH9, ARSG_CANLF | Q96EG1, ARSG_HUMAN |
| Q3TYD4, ARSG_MOUSE | Q32KJ9, ARSG_RAT | Q148F3, ARSK_BOVIN |
| Q32KH0, ARSK_CANLF | Q5ZK90, ARSK_CHICK | Q08CJ7, ARSK_DANRE |
| Q6UWY0, ARSK_HUMAN | Q9D2L1, ARSK_MOUSE | Q32KJ2, ARSK_RAT |
| Q0IHJ2, ARSK_XENLA | P51690, ARSL_HUMAN | Q60HH5, ARSL_MACFA |
| P14217, ARS_CHLRE | P14000, ARS_HEMPU | P51691, ARS_PSEAE |
| P28607, ARS_PSEVC | P50473, ARS_STRPU | Q10723, ARS_VOLCA |
| P20713, ATSA_KLEAE | Q9X759, ATSA_KLEPN | Q0TUK6, SULF_CLOP1 |
| Q8XNV1, SULF_CLOPE |
|
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