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ENZYME

ENZYME entry: EC 3.1.6.1

Accepted Name
arylsulfatase (type I)
Alternative Name(s)
aryl-sulfate sulphohydrolase
sulfatase
Reaction catalysed
an aryl sulfate + H2O = a phenol + H(+) + sulfate
Comment(s)
  • Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors.
  • Arylsulfatases are type I enzymes, found in both prokaryotes and eukaryotes, with rather similar specificities.
  • The key catalytic residue 3-oxo-L-alanine initiates the reaction through a nucleophilic attack on the sulfur atom in the substrate.
  • This residue is generated by post-translational modification of a conserved cysteine or serine residue by EC 1.8.3.7, EC 1.1.98.7, or EC 1.8.98.7.
Cross-references
BRENDA3.1.6.1
EC2PDB3.1.6.1
ExplorEnz3.1.6.1
PRIAM enzyme-specific profiles3.1.6.1
KEGG Ligand Database for Enzyme Nomenclature3.1.6.1
IUBMB Enzyme Nomenclature3.1.6.1
IntEnz3.1.6.1
MEDLINEFind literature relating to 3.1.6.1
MetaCyc3.1.6.1
Rhea expert-curated reactions3.1.6.1
UniProtKB/Swiss-Prot
P54793, ARSF_HUMANQ32KH9, ARSG_CANLFQ96EG1, ARSG_HUMAN
Q3TYD4, ARSG_MOUSEQ32KJ9, ARSG_RATQ148F3, ARSK_BOVIN
Q32KH0, ARSK_CANLFQ5ZK90, ARSK_CHICKQ08CJ7, ARSK_DANRE
Q6UWY0, ARSK_HUMANQ9D2L1, ARSK_MOUSEQ32KJ2, ARSK_RAT
Q0IHJ2, ARSK_XENLAP51690, ARSL_HUMANQ60HH5, ARSL_MACFA
P14217, ARS_CHLREP14000, ARS_HEMPUP51691, ARS_PSEAE
P28607, ARS_PSEVCP50473, ARS_STRPUQ10723, ARS_VOLCA
P20713, ATSA_KLEAEQ9X759, ATSA_KLEPNQ8IWU6, SULF1_HUMAN
Q8K007, SULF1_MOUSEQ8VI60, SULF1_RATQ8IWU5, SULF2_HUMAN
Q8CFG0, SULF2_MOUSEQ0TUK6, SULF_CLOP1Q8XNV1, SULF_CLOPE

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