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ENZYME entry: EC 3.1.6.1

Accepted Name
arylsulfatase (type I).
Alternative Name(s)
aryl-sulfate sulphohydrolase.
sulfatase.
Reaction catalysed
an aryl sulfate + H2O <=> a phenol + H(+) + sulfate
Comment(s)
  • Sulfatase enzymes are classified as type I, in which the key catalytic residue is 3-oxo-L-alanine, type II, which are non-heme iron-dependent dioxygenases, or type III, whose catalytic domain adopts a metallo-beta-lactamase fold and binds two zinc ions as cofactors.
  • Arylsulfatases are type I enzymes, found in both prokaryotes and eukaryotes, with rather similar specificities.
  • The key catalytic residue 3-oxo-L-alanine initiates the reaction through a nucleophilic attack on the sulfur atom in the substrate.
  • This residue is generated by post-translational modification of a conserved cysteine or serine residue by EC 1.8.3.7, EC 1.1.98.7, or EC 1.8.98.7.
Cross-references
BRENDA3.1.6.1
EC2PDB3.1.6.1
ExplorEnz3.1.6.1
PRIAM enzyme-specific profiles3.1.6.1
KEGG Ligand Database for Enzyme Nomenclature3.1.6.1
IUBMB Enzyme Nomenclature3.1.6.1
IntEnz3.1.6.1
MEDLINEFind literature relating to 3.1.6.1
MetaCyc3.1.6.1
Rhea expert-curated reactions3.1.6.1
UniProtKB/Swiss-Prot
P54793, ARSF_HUMAN;  Q32KH9, ARSG_CANLF;  Q96EG1, ARSG_HUMAN;  
Q3TYD4, ARSG_MOUSE;  Q32KJ9, ARSG_RAT;  Q148F3, ARSK_BOVIN;  
Q32KH0, ARSK_CANLF;  Q5ZK90, ARSK_CHICK;  Q08CJ7, ARSK_DANRE;  
Q6UWY0, ARSK_HUMAN;  Q9D2L1, ARSK_MOUSE;  Q32KJ2, ARSK_RAT;  
Q0IHJ2, ARSK_XENLA;  P51690, ARSL_HUMAN;  Q60HH5, ARSL_MACFA;  
P14217, ARS_CHLRE;  P14000, ARS_HEMPU;  P51691, ARS_PSEAE;  
P28607, ARS_PSEVC;  P50473, ARS_STRPU;  Q10723, ARS_VOLCA;  
P20713, ATSA_KLEAE;  Q9X759, ATSA_KLEPN;  Q0TUK6, SULF_CLOP1;  
Q8XNV1, SULF_CLOPE;  

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