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ENZYME entry: EC 2.1.1.152

Accepted Name
Precorrin-6A synthase (deacetylating).
Alternative Name(s)
Precorrin-6X synthase (deacetylating).
Reaction catalysed
S-adenosyl-L-methionine + precorrin-5 + H(2)O <=> S-adenosyl-L-homocysteine + precorrin-6A + acetate
Comment(s)
  • The enzyme, which participates in the aerobic (late cobalt insertion) cobalamin biosythesis pathway, catalyzes two reactions - the methylation of carbon C(1) of precorrin-5, and its deacetylation, forming precorrin-6A.
  • See EC 2.1.1.195 for the C(1)-methyltransferase that participates in the anaerobic cobalamin biosynthesis pathway.
Cross-references
BRENDA2.1.1.152
EC2PDB2.1.1.152
ExplorEnz2.1.1.152
PRIAM enzyme-specific profiles2.1.1.152
KEGG Ligand Database for Enzyme Nomenclature2.1.1.152
IUBMB Enzyme Nomenclature2.1.1.152
IntEnz2.1.1.152
MEDLINEFind literature relating to 2.1.1.152
MetaCyc2.1.1.152
Rhea expert-curated reactions2.1.1.152
UniProtKB/Swiss-Prot
P21636, COBF_SINSX

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