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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Precorrin-6A synthase (deacetylating).
Alternative Name(s)
Precorrin-6X synthase (deacetylating).
Reaction catalysed
S-adenosyl-L-methionine + precorrin-5 + H(2)O <=> S-adenosyl-L-homocysteine + precorrin-6A + acetate
  • In the aerobic cobalamin biosythesis pathway, four enzymes are involved in the conversion of precorrin-3A to precorrin-6A.
  • The first of the four steps is carried out by EC (CobG), yielding precorrin-3B as the product.
  • This is followed by three methylation reactions, which introduce a methyl group at C-17 (CobJ; EC, C-11 (CobM; and C-1 (CobF; EC of the macrocycle, giving rise to precorrin- 4, precorrin-5 and precorrin-6A, respectively.
PRIAM enzyme-specific profiles2.1.1.152
KEGG Ligand Database for Enzyme Nomenclature2.1.1.152
IUBMB Enzyme Nomenclature2.1.1.152
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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