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ENZYME

ENZYME entry: EC 2.1.1.222

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.222
Accepted Name
2-polyprenyl-6-hydroxyphenol methylase
Alternative Name(s)
2-octaprenyl-6-hydroxyphenol methylase
Reaction catalysed
a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • UbiG catalyzes both methylation steps in ubiquinone biosynthesis in Escherichia coli.
  • The second methylation is classified as EC 2.1.1.64.
  • In eukaryotes Coq3 catalyzes the two methylation steps in ubiquinone biosynthesis.
  • However, while the second methylation is common to both enzymes, the first methylation by Coq3 occurs at a different position within the pathway, and thus involves a different substrate and is classified as EC 2.1.1.114.
  • The substrate of the eukaryotic enzyme (3,4-dihydroxy-5-all-trans- polyprenylbenzoate) differs by an additional carboxylate moiety.
Cross-references
BRENDA2.1.1.222
EC2PDB2.1.1.222
ExplorEnz2.1.1.222
KEGG Ligand Database for Enzyme Nomenclature2.1.1.222
IUBMB Enzyme Nomenclature2.1.1.222
MEDLINEFind literature relating to 2.1.1.222
MetaCyc2.1.1.222
Rhea expert-curated reactions2.1.1.222
UniProtKB/Swiss-Prot
Q6FFY1, UBIG_ACIADB7H2Y9, UBIG_ACIB3B7IBN2, UBIG_ACIB5
B2I023, UBIG_ACIBCB0VMN8, UBIG_ACIBSB0V5X4, UBIG_ACIBY
A3MZ07, UBIG_ACTP2B3H0C8, UBIG_ACTP7A4SM99, UBIG_AERS4
Q8UA66, UBIG_AGRFCQ21UL3, UBIG_ALBFTQ5E5J8, UBIG_ALIF1
B5FDT8, UBIG_ALIFMQ0AA73, UBIG_ALKEHQ5P7U3, UBIG_AROAE
A8HVC4, UBIG_AZOC5A1K8Q1, UBIG_AZOSBC1DRQ3, UBIG_AZOVD
A1URT5, UBIG_BARBKQ6G5K3, UBIG_BARHEQ6G0I1, UBIG_BARQU
A9IQF4, UBIG_BART1Q2L2T5, UBIG_BORA1Q7WGT9, UBIG_BORBR
Q7W5Z6, UBIG_BORPAQ7VZG7, UBIG_BORPEQ89XU2, UBIG_BRADU
A4YKT6, UBIG_BRASOB2S828, UBIG_BRUA1Q2YLN5, UBIG_BRUA2
A6WXQ0, UBIG_BRUA4A9M8K8, UBIG_BRUC2C0RFB8, UBIG_BRUMB
Q8YJ98, UBIG_BRUMEA5VSK3, UBIG_BRUO2B0CIC6, UBIG_BRUSI
Q8FYK0, UBIG_BRUSUB1YV26, UBIG_BURA4A0K5L4, UBIG_BURCH
B4EB49, UBIG_BURCJQ0BHA0, UBIG_BURCMQ39IG8, UBIG_BURL3
A9ADW3, UBIG_BURM1Q62M18, UBIG_BURMAB1JXR2, UBIG_BURO0
Q1BY35, UBIG_BURO1Q3JPX1, UBIG_BURP1Q63RZ8, UBIG_BURPS
Q2SY32, UBIG_BURTAA4JCG7, UBIG_BURVGB0SW81, UBIG_CAUSK
Q9A9X1, UBIG_CAUVCB8H209, UBIG_CAUVNA3PNM3, UBIG_CERS1
Q3IYM5, UBIG_CERS4A4WW91, UBIG_CERS5B9KPP7, UBIG_CERSK
Q11E01, UBIG_CHESBQ7NZ91, UBIG_CHRVOA8ADY5, UBIG_CITK8
Q482G8, UBIG_COLP3B6J5Y2, UBIG_COXB1B6J1W2, UBIG_COXB2
A9KGL7, UBIG_COXBNA9NBI0, UBIG_COXBRQ820B5, UBIG_COXBU
A7MPA9, UBIG_CROS8Q46Y42, UBIG_CUPPJQ47GP8, UBIG_DECAR
A8LQ43, UBIG_DINSHA7ZP50, UBIG_ECO24B7UFP4, UBIG_ECO27
B7MFZ8, UBIG_ECO45B7LAP9, UBIG_ECO55Q8XE29, UBIG_ECO57
B5YX17, UBIG_ECO5EB7NN47, UBIG_ECO7IB7MXR3, UBIG_ECO81
B7M5R7, UBIG_ECO8AC4ZU73, UBIG_ECOBWB1X8C6, UBIG_ECODH
A8A296, UBIG_ECOHSQ0TFL0, UBIG_ECOL5Q8FFP0, UBIG_ECOL6
B1IXV6, UBIG_ECOLCP17993, UBIG_ECOLIB7N5J4, UBIG_ECOLU
B6I7I7, UBIG_ECOSEB1LLI3, UBIG_ECOSMQ1R9I4, UBIG_ECOUT
A4WCN5, UBIG_ENT38B2VIL6, UBIG_ERWT9B7LM95, UBIG_ESCF3
B8F4B1, UBIG_GLAP5Q7VKW2, UBIG_HAEDUQ2SE61, UBIG_HAHCH
Q0I3Y4, UBIG_HISS1B0UUV6, UBIG_HISS2Q31GD8, UBIG_HYDCU
Q5QZ53, UBIG_IDILOQ28VP7, UBIG_JANSCB5XNZ3, UBIG_KLEP3
A6TBT7, UBIG_KLEP7B1Y2L3, UBIG_LEPCPQ0AME1, UBIG_MARMM
A1U3K1, UBIG_MARN8Q609G2, UBIG_METCAB8IUB0, UBIG_METNO
B0UAV0, UBIG_METS4B8EI29, UBIG_METSBA9M0C4, UBIG_NEIM0
Q9JWE6, UBIG_NEIMAQ9JXI7, UBIG_NEIMBQ81ZZ2, UBIG_NITEU
Q2Y6Z3, UBIG_NITMUQ3J8U2, UBIG_NITOCQ3SVP3, UBIG_NITWN
A1TSA0, UBIG_PARC0A7HTX8, UBIG_PARL1Q2W6W0, UBIG_PARM1
B2JEZ6, UBIG_PARP8B2T641, UBIG_PARPJQ13VB4, UBIG_PARXL
Q9CMI6, UBIG_PASMUQ6D7X5, UBIG_PECASC6DBN5, UBIG_PECCP
Q4FNA2, UBIG_PELUBQ7N2M5, UBIG_PHOLLQ6LPD7, UBIG_PHOPR
B4EZ30, UBIG_PROMHQ48FM4, UBIG_PSE14B7V9J5, UBIG_PSEA8
Q02PX7, UBIG_PSEABQ9HZ63, UBIG_PSEAEQ1IDA6, UBIG_PSEE4
Q4K8M4, UBIG_PSEF5C3K6J1, UBIG_PSEFSA5W7G3, UBIG_PSEP1
A6V2Q4, UBIG_PSEP7Q3K8T6, UBIG_PSEPFB0KTX4, UBIG_PSEPG
Q88M10, UBIG_PSEPKB1J5G4, UBIG_PSEPWQ885T9, UBIG_PSESM
Q3ILA5, UBIG_PSET1Q4ZQ90, UBIG_PSEU2Q4FVG3, UBIG_PSYA2
Q1QEI9, UBIG_PSYCKQ8Y0Z5, UBIG_RALN1B3PP83, UBIG_RHIE6
Q2K3S8, UBIG_RHIECQ1MBA9, UBIG_RHIJ3Q98G87, UBIG_RHILO
B5ZRR7, UBIG_RHILWQ92MK1, UBIG_RHIMEB9JB78, UBIG_RHIR8
Q2J419, UBIG_RHOP2Q07VB6, UBIG_RHOP5Q6NC69, UBIG_RHOPA
Q21BZ6, UBIG_RHOPBQ13EZ9, UBIG_RHOPSB3QCF3, UBIG_RHOPT
Q2RWE9, UBIG_RHORTA8GPB1, UBIG_RICAHA8GX11, UBIG_RICB8
Q1RJC7, UBIG_RICBRA8EY40, UBIG_RICCKQ92H07, UBIG_RICCN
Q4UME7, UBIG_RICFEQ9ZCT9, UBIG_RICPRQ68WB5, UBIG_RICTY
Q16D32, UBIG_ROSDOQ5LWM6, UBIG_RUEPOQ1GCH8, UBIG_RUEST
Q21IR9, UBIG_SACD2B5EYW1, UBIG_SALA4A9MJY3, UBIG_SALAR
Q57M77, UBIG_SALCHB5FNR7, UBIG_SALDCB5R249, UBIG_SALEP
B5RCA1, UBIG_SALG2B4TBE3, UBIG_SALHSB4SYU8, UBIG_SALNS
Q5PCY1, UBIG_SALPAC0Q093, UBIG_SALPCB5BCS0, UBIG_SALPK
B4TPG0, UBIG_SALSVQ8Z560, UBIG_SALTIP37431, UBIG_SALTY
A8GGX8, UBIG_SERP5A1S6C9, UBIG_SHEAMB8EA88, UBIG_SHEB2
A3D499, UBIG_SHEB5A6WNN7, UBIG_SHEB8A9L2Y4, UBIG_SHEB9
B0TT38, UBIG_SHEHHQ8EEG9, UBIG_SHEONA8H499, UBIG_SHEPA
A4Y759, UBIG_SHEPCA0KWN3, UBIG_SHESAQ0HIX5, UBIG_SHESM
Q0HV07, UBIG_SHESRA1RJD1, UBIG_SHESWB2TW20, UBIG_SHIB3
Q31Z65, UBIG_SHIBSQ32DV8, UBIG_SHIDSQ0T2P9, UBIG_SHIF8
Q820C5, UBIG_SHIFLQ3YZX6, UBIG_SHISSC3MHQ9, UBIG_SINFN
A6UCF6, UBIG_SINMWQ2NSL7, UBIG_SODGMA4VLX7, UBIG_STUS1
Q3SK91, UBIG_THIDAB7VGS0, UBIG_VIBA3A7MU79, UBIG_VIBC1
A5F1U0, UBIG_VIBC3Q9KSJ9, UBIG_VIBCHC3LLV3, UBIG_VIBCM
Q87ND5, UBIG_VIBPAQ8D8E0, UBIG_VIBVUQ7MM27, UBIG_VIBVY
Q8PK00, UBIG_XANACQ4UVL4, UBIG_XANC8B0RS27, UBIG_XANCB
Q8P8H2, UBIG_XANCPQ3BSF8, UBIG_XANE5Q2P2C4, UBIG_XANOM
B2SHS9, UBIG_XANOPQ5GZB5, UBIG_XANORB2I705, UBIG_XYLF2
Q9PAM5, UBIG_XYLFAB0U3W1, UBIG_XYLFMQ87BG5, UBIG_XYLFT
A1JLA0, UBIG_YERE8A7FKF4, UBIG_YERP3Q1C9H5, UBIG_YERPA
B2K9A4, UBIG_YERPBQ8ZGR6, UBIG_YERPEA9R284, UBIG_YERPG
Q1CFZ1, UBIG_YERPNA4TNI8, UBIG_YERPPQ66CZ4, UBIG_YERPS
B1JS96, UBIG_YERPY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-