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ENZYME entry: EC 2.1.1.246

Accepted Name
[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase.
Reaction catalysed
coenzyme M + methyl-Co(III)-[methanol-specific corrinoid protein] <=> Co(I)-[methanol-specific corrinoid protein] + H(+) + methyl-coenzyme M
Comment(s)
  • The enzyme, which is involved in methanogenesis from methanol, catalyzes the transfer of a methyl group from a corrinoid protein (see EC 2.1.1.90), where it is bound to the cobalt cofactor, to coenzyme M, forming the substrate for EC 2.8.4.1, the enzyme that catalyzes the final step in methanogenesis.
  • Free methylcob(I)alamin can substitute for the corrinoid protein in vitro.
Cross-references
BRENDA2.1.1.246
EC2PDB2.1.1.246
ExplorEnz2.1.1.246
PRIAM enzyme-specific profiles2.1.1.246
KEGG Ligand Database for Enzyme Nomenclature2.1.1.246
IUBMB Enzyme Nomenclature2.1.1.246
IntEnz2.1.1.246
MEDLINEFind literature relating to 2.1.1.246
MetaCyc2.1.1.246
Rhea expert-curated reactions2.1.1.246
UniProtKB/Swiss-Prot
Q48927, MTAA_METBA;  Q48949, MTAA_METBF;  

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