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ENZYME

ENZYME entry: EC 2.1.1.251

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.251
Accepted Name
methylated-thiol--coenzyme M methyltransferase
Reaction catalysed
methanethiol + coenzyme M = methyl-coenzyme M + hydrogen sulfide + H(+)
Comment(s)
  • The enzyme, which is involved in methanogenesis from methylated thiols, such as methane thiol, dimethyl sulfide, and 3-(methylsulfanyl)propanoate, catalyzes two successive steps - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M.
  • With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC 2.1.1.90 and EC 2.1.1.246).
  • The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation.
Cross-references
BRENDA2.1.1.251
EC2PDB2.1.1.251
ExplorEnz2.1.1.251
KEGG Ligand Database for Enzyme Nomenclature2.1.1.251
IUBMB Enzyme Nomenclature2.1.1.251
MEDLINEFind literature relating to 2.1.1.251
MetaCyc2.1.1.251
Rhea expert-curated reactions2.1.1.251
UniProtKB/Swiss-Prot
Q48924, MTSA_METBAQ8PUA8, MTSA_METMA

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