Home  |  Contact

ENZYME entry: EC 2.1.1.251

Accepted Name
Methylated-thiol--coenzyme M methyltransferase.
Reaction catalysed
Methanethiol + coenzyme M <=> methyl-CoM + hydrogen sulfide
Comment(s)
  • The enzyme, which is involved in methanogenesis from methylated thiols, such as methane thiol, dimethyl sulfide, and 3-S- methylmercaptopropionate, catalyzes two successive steps - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M.
  • With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC 2.1.1.90 and EC 2.1.1.246).
  • The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation.
Cross-references
BRENDA2.1.1.251
EC2PDB2.1.1.251
ExplorEnz2.1.1.251
PRIAM enzyme-specific profiles2.1.1.251
KEGG Ligand Database for Enzyme Nomenclature2.1.1.251
IUBMB Enzyme Nomenclature2.1.1.251
IntEnz2.1.1.251
MEDLINEFind literature relating to 2.1.1.251
MetaCyc2.1.1.251
UniProtKB/Swiss-Prot
Q48924, MTSA_METBA;  Q8PUA8, MTSA_METMA;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-