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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.1.1.251

Accepted Name
Methylated-thiol--coenzyme M methyltransferase.
Reaction catalysed
Methanethiol + coenzyme M <=> methyl-CoM + hydrogen sulfide
Comment(s)
  • The enzyme, which is involved in methanogenesis from methylated thiols, such as methane thiol, dimethyl sulfide, and 3-S- methylmercaptopropionate, catalyzes two successive steps - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M.
  • With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC 2.1.1.90 and EC 2.1.1.246).
  • The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation.
Cross-references
BRENDA2.1.1.251
EC2PDB2.1.1.251
ExplorEnz2.1.1.251
PRIAM enzyme-specific profiles2.1.1.251
KEGG Ligand Database for Enzyme Nomenclature2.1.1.251
IUBMB Enzyme Nomenclature2.1.1.251
IntEnz2.1.1.251
MEDLINEFind literature relating to 2.1.1.251
MetaCyc2.1.1.251
UniProtKB/Swiss-Prot
Q48924, MTSA_METBA;  Q8PUA8, MTSA_METMA;  

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