ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.1.1.251

Accepted Name

Methylated-thiol--coenzyme M methyltransferase.

Reaction catalysed

Methanethiol + coenzyme M <=> methyl-CoM + hydrogen sulfide

Comment(s)

The enzyme, which is involved in methanogenesis from methylated thiols, such as methane thiol, dimethyl sulfide, and 3-S- methylmercaptopropionate, catalyzes two successive steps - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M.
With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC 2.1.1.90 and EC 2.1.1.246).
The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature