ENZYME entry: EC 188.8.131.52
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|Methylated-thiol--coenzyme M methyltransferase.
|Methanethiol + coenzyme M <=> methyl-CoM + hydrogen sulfide|
- The enzyme, which is involved in methanogenesis from methylated
thiols, such as methane thiol, dimethyl sulfide,
and 3-(methylsulfanyl)propanoate, catalyzes two successive steps -
the transfer of a methyl group from the substrate to the cobalt
cofactor of a methylated-thiol-specific corrinoid protein (MtsB),
and the subsequent transfer of the methyl group from the corrinoid
protein to coenzyme M.
- With most other methanogenesis substrates this process is carried out
by two different enzymes (for example, EC 184.108.40.206 and EC 220.127.116.11).
- The cobalt is oxidized during methylation from the Co(I) state to the
Co(III) state, and is reduced back to the Co(I) form during
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
|Rhea expert-curated reactions||184.108.40.206|
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