ENZYME entry: EC 2.1.1.251
Accepted Name |
Methylated-thiol--coenzyme M methyltransferase.
|
Reaction catalysed |
Methanethiol + coenzyme M <=> methyl-CoM + hydrogen sulfide |
Comment(s) |
- The enzyme, which is involved in methanogenesis from methylated
thiols, such as methane thiol, dimethyl sulfide,
and 3-(methylsulfanyl)propanoate, catalyzes two successive steps -
the transfer of a methyl group from the substrate to the cobalt
cofactor of a methylated-thiol-specific corrinoid protein (MtsB),
and the subsequent transfer of the methyl group from the corrinoid
protein to coenzyme M.
- With most other methanogenesis substrates this process is carried out
by two different enzymes (for example, EC 2.1.1.90 and EC 2.1.1.246).
- The cobalt is oxidized during methylation from the Co(I) state to the
Co(III) state, and is reduced back to the Co(I) form during
demethylation.
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Cross-references |
BRENDA | 2.1.1.251 |
EC2PDB | 2.1.1.251 |
ExplorEnz | 2.1.1.251 |
PRIAM enzyme-specific profiles | 2.1.1.251 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.251 |
IUBMB Enzyme Nomenclature | 2.1.1.251 |
IntEnz | 2.1.1.251 |
MEDLINE | Find literature relating to 2.1.1.251 |
MetaCyc | 2.1.1.251 |
Rhea expert-curated reactions | 2.1.1.251 |
UniProtKB/Swiss-Prot |
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