Expasy logo

ENZYME

ENZYME entry: EC 2.1.1.251

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.251
Accepted Name
methylated-thiol--coenzyme M methyltransferase
Reaction catalysed
methanethiol + coenzyme M = methyl-coenzyme M + hydrogen sulfide + H(+)
Comment(s)
  • The enzyme, which is involved in methanogenesis from methylated thiols, such as methane thiol, dimethyl sulfide, and 3-(methylsulfanyl)propanoate, catalyzes two successive steps - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M.
  • With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC 2.1.1.90 and EC 2.1.1.246).
  • The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation.
Cross-references
Rhea expert-curated reactions2.1.1.251
ExplorEnz2.1.1.251
IUBMB Enzyme Nomenclature2.1.1.251
UniProtKB/Swiss-Prot
Q48924, MTSA_METBAQ8PUA8, MTSA_METMA
BRENDA2.1.1.251
MetaCyc2.1.1.251
KEGG Ligand Database for Enzyme Nomenclature2.1.1.251
EC2PDB2.1.1.251
MEDLINEFind literature relating to 2.1.1.251

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-