ENZYME entry: EC 2.1.1.314

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.314

Accepted Name

diphthine methyl ester synthase

Alternative Name(s)

diphthine methyltransferase

Reaction catalysed

2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)

Comment(s)

This eukaryotic enzyme is part of the biosynthetic pathway of diphthamide.
Different from the archaeal enzyme, which performs only 3 methylations, producing diphthine (cf. EC 2.1.1.98).
The relevant histidine of elongation factor 2 is His(715) in mammals and His(699) in yeast.

Cross-references

BRENDA

2.1.1.314

EC2PDB

2.1.1.314

ExplorEnz

2.1.1.314

KEGG Ligand Database for Enzyme Nomenclature

2.1.1.314

IUBMB Enzyme Nomenclature

2.1.1.314

MEDLINE

Find literature relating to 2.1.1.314

MetaCyc

2.1.1.314

Rhea expert-curated reactions

2.1.1.314

UniProtKB/Swiss-Prot

Q59NX9, DPH51_CANAL	P0CU37, DPH52_CANAL	O81769, DPH5_ARATH
Q6MY91, DPH5_ASPFU	Q5E982, DPH5_BOVIN	Q6FXK9, DPH5_CANGA
Q6BN80, DPH5_DEBHA	Q75JG8, DPH5_DICDI	Q5BFG0, DPH5_EMENI
Q754E7, DPH5_EREGS	Q4HZI0, DPH5_GIBZE	Q9H2P9, DPH5_HUMAN
Q6CIZ1, DPH5_KLULA	Q9CWQ0, DPH5_MOUSE	Q7S949, DPH5_NEUCR
O74898, DPH5_SCHPO	Q6C1E0, DPH5_YARLI	P32469, DPH5_YEAST

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-