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ENZYME entry: EC 2.1.1.314

Accepted Name
Diphthine methyl ester synthase.
Alternative Name(s)
Diphthine methyltransferase.
Reaction catalysed
4 S-adenosyl-L-methionine + 2-((3S)-3-carboxy-3-aminopropyl)-L-histidine-[translation elongation factor 2] <=> 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]
Comment(s)
  • This eukaryotic enzyme is part of the biosynthetic pathway of diphthamide.
  • Different from the archaeal enzyme, which performs only 3 methylations, producing diphthine (cf. EC 2.1.1.98).
  • The relevant histidine of elongation factor 2 is His(715) in mammals and His(699) in yeast.
Cross-references
BRENDA2.1.1.314
EC2PDB2.1.1.314
ExplorEnz2.1.1.314
PRIAM enzyme-specific profiles2.1.1.314
KEGG Ligand Database for Enzyme Nomenclature2.1.1.314
IUBMB Enzyme Nomenclature2.1.1.314
IntEnz2.1.1.314
MEDLINEFind literature relating to 2.1.1.314
MetaCyc2.1.1.314
UniProtKB/Swiss-Prot
Q59NX9, DPH51_CANAL;  P0CU37, DPH52_CANAL;  O81769, DPH5_ARATH;  
Q754E7, DPH5_ASHGO;  Q6MY91, DPH5_ASPFU;  Q5E982, DPH5_BOVIN;  
Q6FXK9, DPH5_CANGA;  Q6BN80, DPH5_DEBHA;  Q75JG8, DPH5_DICDI;  
Q5BFG0, DPH5_EMENI;  Q4HZI0, DPH5_GIBZE;  Q9H2P9, DPH5_HUMAN;  
Q6CIZ1, DPH5_KLULA;  Q9CWQ0, DPH5_MOUSE;  Q7S949, DPH5_NEUCR;  
O74898, DPH5_SCHPO;  Q6C1E0, DPH5_YARLI;  P32469, DPH5_YEAST;  

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