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ENZYME

ENZYME entry: EC 2.1.1.98

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.98
Accepted Name
diphthine synthase
Reaction catalysed
2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 S-adenosyl-L-homocysteine + 3 H(+)
Comment(s)
  • This archaeal enzyme produces the trimethylated product diphthine, which is converted into diphthamide by EC 6.3.1.14.
  • Different from the eukaryotic enzyme, which produces diphthine methyl ester (cf. EC 2.1.1.314).
  • In the archaeon Pyrococcus horikoshii the enzyme acts on His(600) of elongation factor 2.
Cross-references
BRENDA2.1.1.98
EC2PDB2.1.1.98
ExplorEnz2.1.1.98
KEGG Ligand Database for Enzyme Nomenclature2.1.1.98
IUBMB Enzyme Nomenclature2.1.1.98
MEDLINEFind literature relating to 2.1.1.98
MetaCyc2.1.1.98
Rhea expert-curated reactions2.1.1.98
UniProtKB/Swiss-Prot
Q9YDI2, DPHB_AERPEO29866, DPHB_ARCFUB9LV13, DPHB_HALLT
Q5V2B7, DPHB_HALMAB0R4W9, DPHB_HALS3Q9HQK6, DPHB_HALSA
Q18JS3, DPHB_HALWDA6UU49, DPHB_META3Q8TR14, DPHB_METAC
Q0W085, DPHB_METARA7IA21, DPHB_METB6Q467Z4, DPHB_METBF
Q12XB4, DPHB_METBUQ2FQ45, DPHB_METHJQ58670, DPHB_METJA
Q8TXC7, DPHB_METKAA2SQF6, DPHB_METLZA4FYP1, DPHB_METM5
A9A6D8, DPHB_METM6A6VJP1, DPHB_METM7Q8PUH9, DPHB_METMA
A3CWF9, DPHB_METMJQ6LZN6, DPHB_METMPB8GIF8, DPHB_METPE
A4YHI8, DPHB_METS5Q2NFJ8, DPHB_METSTO27902, DPHB_METTH
A0B879, DPHB_METTPA6US81, DPHB_METVSQ3IS55, DPHB_NATPD
Q9UZ31, DPHB_PYRABQ8ZXR9, DPHB_PYRAEA3MU14, DPHB_PYRCJ
Q8U377, DPHB_PYRFUO58456, DPHB_PYRHOA1RU15, DPHB_PYRIL
B1YAU2, DPHB_PYRNVC3NHR8, DPHB_SACI1C3MPQ5, DPHB_SACI2
C3N5D1, DPHB_SACI3C3MYP9, DPHB_SACI4C4KGZ7, DPHB_SACI6
C3NDY5, DPHB_SACI7Q97TX8, DPHB_SACS2A3DLV7, DPHB_STAMF
Q971V1, DPHB_SULTOQ9HJT0, DPHB_THEACC5A3K4, DPHB_THEGJ
Q5JFE7, DPHB_THEKOB6YXP9, DPHB_THEONQ979Z8, DPHB_THEVO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
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