ENZYME entry: EC 2.1.1.320
Accepted Name |
Type II protein arginine methyltransferase.
|
Reaction catalysed |
2 S-adenosyl-L-methionine + [protein]-L-arginine <=> 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega')-dimethyl-L-arginine |
Comment(s) |
- The enzyme catalyzes the methylation of one of the terminal guanidino
nitrogen atoms in arginine residues within proteins, forming
monomethylarginine, followed by the methylation of the second
terminal nitrogen atom to form a symmetrical dimethylarginine.
- The mammalian enzyme is active in both the nucleus and the cytoplasm,
and plays a role in the assembly of snRNP core particles by
methylating certain small nuclear ribonucleoproteins.
- Cf. EC 2.1.1.319, EC 2.1.1.321 and EC 2.1.1.322.
- Formerly EC 2.1.1.23, EC 2.1.1.124, EC 2.1.1.125 and EC 2.1.1.126.
|
Cross-references |
BRENDA | 2.1.1.320 |
EC2PDB | 2.1.1.320 |
ExplorEnz | 2.1.1.320 |
PRIAM enzyme-specific profiles | 2.1.1.320 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.320 |
IUBMB Enzyme Nomenclature | 2.1.1.320 |
IntEnz | 2.1.1.320 |
MEDLINE | Find literature relating to 2.1.1.320 |
MetaCyc | 2.1.1.320 |
Rhea expert-curated reactions | 2.1.1.320 |
UniProtKB/Swiss-Prot |
A7YW45, ANM5_BOVIN; | P46580, ANM5_CAEEL; | Q54KI3, ANM5_DICDI; |
O14744, ANM5_HUMAN; | Q4R5M3, ANM5_MACFA; | Q8CIG8, ANM5_MOUSE; |
A2X0Q3, ANM5_ORYSI; | Q6YXZ7, ANM5_ORYSJ; | Q5R698, ANM5_PONAB; |
Q6NUA1, ANM5_XENLA; | Q6P2P2, ANM9_HUMAN; | Q3U3W5, ANM9_MOUSE; |
A0JMU5, ANM9_XENLA; | P38274, HSL7_YEAST; | Q2KHV5, NDUF7_BOVIN; |
Q09644, NDUF7_CAEEL; | Q08BY0, NDUF7_DANRE; | Q54S83, NDUF7_DICDI; |
Q9VGR2, NDUF7_DROME; | Q7L592, NDUF7_HUMAN; | Q9CWG8, NDUF7_MOUSE; |
Q5XI79, NDUF7_RAT; | O14138, NDUF7_SCHPO; | Q6GQ37, NDUF7_XENLA; |
Q5BKM6, NDUF7_XENTR; | P36052, NDUF7_YEAST; |
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