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ENZYME

ENZYME entry: EC 2.1.1.319

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.319
Accepted Name
type I protein arginine methyltransferase
Reaction catalysed
L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)
Comment(s)
  • This eukaryotic enzyme catalyzes the sequential dimethylation of one of the terminal guanidino nitrogen atoms in arginine residues, resulting in formation of asymmetric dimethylarginine residues.
  • Some forms (e.g. PRMT1) have a very wide substrate specificity, while others (e.g. PRMT4 and PRMT6) are rather specific.
  • The enzyme has a preference for methylating arginine residues that are flanked by one or more glycine residues.
  • PRMT1 is responsible for the bulk (about 85%) of total protein arginine methylation activity in mammalian cells. cf. EC 2.1.1.320, EC 2.1.1.321 and EC 2.1.1.322.
  • Formerly EC 2.1.1.23, EC 2.1.1.124, EC 2.1.1.125 and EC 2.1.1.126.
Cross-references
BRENDA2.1.1.319
EC2PDB2.1.1.319
ExplorEnz2.1.1.319
KEGG Ligand Database for Enzyme Nomenclature2.1.1.319
IUBMB Enzyme Nomenclature2.1.1.319
MEDLINEFind literature relating to 2.1.1.319
MetaCyc2.1.1.319
Rhea expert-curated reactions2.1.1.319
UniProtKB/Swiss-Prot
Q9MAT5, ANM10_ARATHA2Y953, ANM10_ORYSIQ9SNQ2, ANM10_ORYSJ
Q9SU94, ANM11_ARATHQ84W92, ANM13_ARATHA3KPF2, ANM14_ARATH
Q8GWT4, ANM15_ARATHQ8AV13, ANM1A_XENLAQ6VRB0, ANM1B_XENLA
Q9U2X0, ANM1_CAEELA8IEF3, ANM1_CHLREQ54EF2, ANM1_DICDI
Q99873, ANM1_HUMANQ9JIF0, ANM1_MOUSEA2Z0C0, ANM1_ORYSI
Q0J2C6, ANM1_ORYSJQ63009, ANM1_RATQ9URX7, ANM1_SCHPO
Q28F07, ANM1_XENTRP38074, ANM1_YEASTQ54HI0, ANM2_DICDI
P55345, ANM2_HUMANQ9R144, ANM2_MOUSED9IVE5, ANM2_XENLA
B3DLB3, ANM2_XENTRQ0WVD6, ANM3_ARATHO60678, ANM3_HUMAN
Q922H1, ANM3_MOUSEA2YP56, ANM3_ORYSIA3BMN9, ANM3_ORYSJ
O70467, ANM3_RATO13648, ANM3_SCHPOQ5E9L5, ANM6_BOVIN
Q6NWG4, ANM6_DANREQ96LA8, ANM6_HUMANQ6NZB1, ANM6_MOUSE
Q68EZ3, ANM6_XENLAB0JYW5, ANM6_XENTRQ5RGQ2, ANM8B_DANRE
Q9NR22, ANM8_HUMANQ6PAK3, ANM8_MOUSEQ174R2, CARM1_AEDAE
Q7Q2B7, CARM1_ANOGAB0W3L6, CARM1_CULQUQ6DC04, CARM1_DANRE
B3M1E1, CARM1_DROANB3P4N5, CARM1_DROERB4JXV2, CARM1_DROGR
Q9VH48, CARM1_DROMEB4KA23, CARM1_DROMOB4GZ20, CARM1_DROPE
Q29B63, CARM1_DROPSB4HJC0, CARM1_DROSEB4QVW6, CARM1_DROSI
B4LVS8, CARM1_DROVIB4NKI9, CARM1_DROWIB4PVH6, CARM1_DROYA
Q86X55, CARM1_HUMANQ9WVG6, CARM1_MOUSEA2YPT7, CARM1_ORYSI
Q7XI75, CARM1_ORYSJQ4AE70, CARM1_RATA0A3Q0KHE7, CARM1_SCHMA
Q5XK84, CARM1_XENLAQ86XA0, MET23_HUMANA2AA28, MET23_MOUSE
Q5RJL2, MET23_RATQ6DJF8, MET23_XENLA

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