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ENZYME entry: EC 2.1.1.319

Accepted Name
type I protein arginine methyltransferase.
Reaction catalysed
L-arginyl-[protein] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine
Comment(s)
  • This eukaryotic enzyme catalyzes the sequential dimethylation of one of the terminal guanidino nitrogen atoms in arginine residues, resulting in formation of asymmetric dimethylarginine residues.
  • Some forms (e.g. PRMT1) have a very wide substrate specificity, while others (e.g. PRMT4 and PRMT6) are rather specific.
  • The enzyme has a preference for methylating arginine residues that are flanked by one or more glycine residues.
  • PRMT1 is responsible for the bulk (about 85%) of total protein arginine methylation activity in mammalian cells.
  • Cf. EC 2.1.1.320, EC 2.1.1.321 and EC 2.1.1.322.
  • Formerly EC 2.1.1.23, EC 2.1.1.124, EC 2.1.1.125 and EC 2.1.1.126.
Cross-references
BRENDA2.1.1.319
EC2PDB2.1.1.319
ExplorEnz2.1.1.319
PRIAM enzyme-specific profiles2.1.1.319
KEGG Ligand Database for Enzyme Nomenclature2.1.1.319
IUBMB Enzyme Nomenclature2.1.1.319
IntEnz2.1.1.319
MEDLINEFind literature relating to 2.1.1.319
MetaCyc2.1.1.319
Rhea expert-curated reactions2.1.1.319
UniProtKB/Swiss-Prot
Q9MAT5, ANM10_ARATH;  A2Y953, ANM10_ORYSI;  Q9SNQ2, ANM10_ORYSJ;  
Q9SU94, ANM11_ARATH;  Q84W92, ANM13_ARATH;  A3KPF2, ANM14_ARATH;  
Q8GWT4, ANM15_ARATH;  Q8AV13, ANM1A_XENLA;  Q6VRB0, ANM1B_XENLA;  
Q9U2X0, ANM1_CAEEL;  Q54EF2, ANM1_DICDI;  Q99873, ANM1_HUMAN;  
Q9JIF0, ANM1_MOUSE;  Q63009, ANM1_RAT;  Q28F07, ANM1_XENTR;  
Q54HI0, ANM2_DICDI;  P55345, ANM2_HUMAN;  Q9R144, ANM2_MOUSE;  
D9IVE5, ANM2_XENLA;  B3DLB3, ANM2_XENTR;  O60678, ANM3_HUMAN;  
Q922H1, ANM3_MOUSE;  O70467, ANM3_RAT;  Q5E9L5, ANM6_BOVIN;  
Q6NWG4, ANM6_DANRE;  Q96LA8, ANM6_HUMAN;  Q6NZB1, ANM6_MOUSE;  
Q68EZ3, ANM6_XENLA;  B0JYW5, ANM6_XENTR;  Q5RGQ2, ANM8B_DANRE;  
Q9NR22, ANM8_HUMAN;  Q6PAK3, ANM8_MOUSE;  Q174R2, CARM1_AEDAE;  
Q7Q2B7, CARM1_ANOGA;  B0W3L6, CARM1_CULQU;  Q6DC04, CARM1_DANRE;  
B3M1E1, CARM1_DROAN;  B3P4N5, CARM1_DROER;  B4JXV2, CARM1_DROGR;  
Q9VH48, CARM1_DROME;  B4KA23, CARM1_DROMO;  B4GZ20, CARM1_DROPE;  
Q29B63, CARM1_DROPS;  B4HJC0, CARM1_DROSE;  B4QVW6, CARM1_DROSI;  
B4LVS8, CARM1_DROVI;  B4NKI9, CARM1_DROWI;  B4PVH6, CARM1_DROYA;  
Q86X55, CARM1_HUMAN;  Q9WVG6, CARM1_MOUSE;  A2YPT7, CARM1_ORYSI;  
Q7XI75, CARM1_ORYSJ;  Q4AE70, CARM1_RAT;  Q5XK84, CARM1_XENLA;  
Q86XA0, MET23_HUMAN;  A2AA28, MET23_MOUSE;  Q5RJL2, MET23_RAT;  
Q6DJF8, MET23_XENLA;  

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