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ENZYME entry: EC 2.1.1.354

Accepted Name
[Histone H3]-lysine(4) N-trimethyltransferase.
Reaction catalysed
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) <=> 3 S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(4)
Comment(s)
  • This entry describes several enzymes that successively methylate the L-lysine(4) residue of histone H3 (H3K4), ultimately generating a trimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • In most cases the trimethylation of this position is associated with gene activation.
  • EC 2.1.1.364 describes enzymes that can catalyze only monomethylation of this substrate (the first sub-reaction of this entry).
  • Formerly EC 2.1.1.43.
Cross-references
BRENDA2.1.1.354
EC2PDB2.1.1.354
ExplorEnz2.1.1.354
PRIAM enzyme-specific profiles2.1.1.354
KEGG Ligand Database for Enzyme Nomenclature2.1.1.354
IUBMB Enzyme Nomenclature2.1.1.354
IntEnz2.1.1.354
MEDLINEFind literature relating to 2.1.1.354
MetaCyc2.1.1.354
UniProtKB/Swiss-Prot
Q9VW15, ASH1_DROME;  Q84WW6, ASHH1_ARATH;  Q9C5X4, ATX1_ARATH;  
O23372, ATXR3_ARATH;  F4K1J4, ATXR7_ARATH;  Q03164, KMT2A_HUMAN;  
P55200, KMT2A_MOUSE;  Q9UMN6, KMT2B_HUMAN;  O08550, KMT2B_MOUSE;  
Q8NEZ4, KMT2C_HUMAN;  Q8BRH4, KMT2C_MOUSE;  O14686, KMT2D_HUMAN;  
Q6PDK2, KMT2D_MOUSE;  Q6P2A1, PRDM9_DANRE;  Q9NQV7, PRDM9_HUMAN;  
Q96EQ9, PRDM9_MOUSE;  P0C6Y7, PRDM9_RAT;  Q1LY77, SE1BA_DANRE;  
O15047, SET1A_HUMAN;  E9PYH6, SET1A_MOUSE;  Q5F3P8, SET1B_CHICK;  
Q9UPS6, SET1B_HUMAN;  Q8CFT2, SET1B_MOUSE;  Q66J90, SET1B_XENLA;  
Q08D57, SET1B_XENTR;  Q75D88, SET1_ASHGO;  Q4WNH8, SET1_ASPFU;  
Q2UMH3, SET1_ASPOR;  Q5ABG1, SET1_CANAL;  Q6FKB1, SET1_CANGA;  
Q2GWF3, SET1_CHAGB;  Q1DR06, SET1_COCIM;  P0CO27, SET1_CRYNB;  
P0CO26, SET1_CRYNJ;  Q6BKL7, SET1_DEBHA;  Q54HS3, SET1_DICDI;  
Q5LJZ2, SET1_DROME;  Q5B0Y5, SET1_EMENI;  Q4I5R3, SET1_GIBZE;  
Q6CIT4, SET1_KLULA;  Q8X0S9, SET1_NEUCR;  Q9Y7R4, SET1_SCHPO;  
Q4PB36, SET1_USTMA;  Q6CEK8, SET1_YARLI;  P38827, SET1_YEAST;  
Q5BJI7, SMY2A_DANRE;  Q7ZXV5, SMY2A_XENLA;  Q5RGL7, SMY2B_DANRE;  
Q6GN68, SMY2B_XENLA;  Q8NB12, SMYD1_HUMAN;  P97443, SMYD1_MOUSE;  
Q0P585, SMYD2_BOVIN;  E1C5V0, SMYD2_CHICK;  Q9NRG4, SMYD2_HUMAN;  
Q8R5A0, SMYD2_MOUSE;  C3RZA1, SMYD2_PIG;  Q7M6Z3, SMYD2_RAT;  
Q9H7B4, SMYD3_HUMAN;  Q9CWR2, SMYD3_MOUSE;  Q1L8U8, STB1A_DANRE;  
Q08BR4, STB1B_DANRE;  Q8IRW8, TRR_DROME;  

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