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ENZYME

ENZYME entry: EC 2.1.1.354

Accepted Name
[histone H3]-lysine(4) N-trimethyltransferase
Reaction catalysed
L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine
Comment(s)
  • This entry describes several enzymes that successively methylate the L-lysine(4) residue of histone H3 (H3K4), ultimately generating a trimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • In most cases the trimethylation of this position is associated with gene activation.
  • EC 2.1.1.364 describes enzymes that can catalyze only monomethylation of this substrate (the first sub-reaction of this entry).
  • Formerly EC 2.1.1.43.
Cross-references
BRENDA2.1.1.354
EC2PDB2.1.1.354
ExplorEnz2.1.1.354
PRIAM enzyme-specific profiles2.1.1.354
KEGG Ligand Database for Enzyme Nomenclature2.1.1.354
IUBMB Enzyme Nomenclature2.1.1.354
IntEnz2.1.1.354
MEDLINEFind literature relating to 2.1.1.354
MetaCyc2.1.1.354
Rhea expert-curated reactions2.1.1.354
UniProtKB/Swiss-Prot
Q9VW15, ASH1_DROMEQ84WW6, ASHH1_ARATHQ9C5X4, ATX1_ARATH
O23372, ATXR3_ARATHF4K1J4, ATXR7_ARATHQ6P2A1, PRDM9_DANRE
Q9NQV7, PRDM9_HUMANQ96EQ9, PRDM9_MOUSEP0C6Y7, PRDM9_RAT
Q1LY77, SE1BA_DANREQ5F3P8, SET1B_CHICKQ66J90, SET1B_XENLA
Q08D57, SET1B_XENTRQ75D88, SET1_ASHGOQ4WNH8, SET1_ASPFU
Q2UMH3, SET1_ASPORQ5ABG1, SET1_CANALQ6FKB1, SET1_CANGA
Q2GWF3, SET1_CHAGBQ1DR06, SET1_COCIMP0CO27, SET1_CRYNB
P0CO26, SET1_CRYNJQ6BKL7, SET1_DEBHAQ54HS3, SET1_DICDI
Q5LJZ2, SET1_DROMEQ5B0Y5, SET1_EMENIQ4I5R3, SET1_GIBZE
Q6CIT4, SET1_KLULAQ8X0S9, SET1_NEUCRQ9Y7R4, SET1_SCHPO
Q4PB36, SET1_USTMAQ6CEK8, SET1_YARLIP38827, SET1_YEAST
Q5BJI7, SMY2A_DANREQ7ZXV5, SMY2A_XENLAQ5RGL7, SMY2B_DANRE
Q6GN68, SMY2B_XENLAQ8NB12, SMYD1_HUMANP97443, SMYD1_MOUSE
Q0P585, SMYD2_BOVINE1C5V0, SMYD2_CHICKQ9NRG4, SMYD2_HUMAN
Q8R5A0, SMYD2_MOUSEC3RZA1, SMYD2_PIGQ7M6Z3, SMYD2_RAT
Q9H7B4, SMYD3_HUMANQ9CWR2, SMYD3_MOUSEQ1L8U8, STB1A_DANRE
Q08BR4, STB1B_DANREQ8IRW8, TRR_DROME

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