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ENZYME entry: EC 2.1.1.354

Accepted Name
[Histone H3]-lysine(4) N-trimethyltransferase.
Reaction catalysed
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) <=> 3 S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(4)
Comment(s)
  • This entry describes several enzymes that successively methylate the L-lysine(4) residue of histone H3 (H3K4), ultimately generating a trimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • In most cases the trimethylation of this position is associated with gene activation.
  • Unlike the other enzymes, KMT7 catalyzes only monomethylation.
  • Formerly EC 2.1.1.34.
Cross-references
BRENDA2.1.1.354
EC2PDB2.1.1.354
ExplorEnz2.1.1.354
PRIAM enzyme-specific profiles2.1.1.354
KEGG Ligand Database for Enzyme Nomenclature2.1.1.354
IUBMB Enzyme Nomenclature2.1.1.354
IntEnz2.1.1.354
MEDLINEFind literature relating to 2.1.1.354
MetaCyc2.1.1.354
UniProtKB/Swiss-Prot
Q84WW6, ASHH1_ARATH;  O23372, ATXR3_ARATH;  Q03164, KMT2A_HUMAN;  
P55200, KMT2A_MOUSE;  Q9UMN6, KMT2B_HUMAN;  O08550, KMT2B_MOUSE;  
Q8NEZ4, KMT2C_HUMAN;  Q8BRH4, KMT2C_MOUSE;  O14686, KMT2D_HUMAN;  
Q6PDK2, KMT2D_MOUSE;  O15047, SET1A_HUMAN;  E9PYH6, SET1A_MOUSE;  
Q5F3P8, SET1B_CHICK;  Q9UPS6, SET1B_HUMAN;  Q8CFT2, SET1B_MOUSE;  
Q66J90, SET1B_XENLA;  Q08D57, SET1B_XENTR;  Q75D88, SET1_ASHGO;  
Q4WNH8, SET1_ASPFU;  Q2UMH3, SET1_ASPOR;  Q5ABG1, SET1_CANAL;  
Q6FKB1, SET1_CANGA;  Q2GWF3, SET1_CHAGB;  Q1DR06, SET1_COCIM;  
P0CO27, SET1_CRYNB;  P0CO26, SET1_CRYNJ;  Q6BKL7, SET1_DEBHA;  
Q54HS3, SET1_DICDI;  Q5LJZ2, SET1_DROME;  Q5B0Y5, SET1_EMENI;  
Q4I5R3, SET1_GIBZE;  Q6CIT4, SET1_KLULA;  Q8X0S9, SET1_NEUCR;  
Q9Y7R4, SET1_SCHPO;  Q4PB36, SET1_USTMA;  Q6CEK8, SET1_YARLI;  
P38827, SET1_YEAST;  Q9H7B4, SMYD3_HUMAN;  Q9CWR2, SMYD3_MOUSE;  

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