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ENZYME entry: EC 2.1.1.364

Accepted Name
[Histone H3]-lysine(4) N-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) <=> S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Comment(s)
  • This entry describes enzymes that catalyze a single methylation of the L-lysine(4) residue of histone H3 (H3K4), generating a monomethylated form.
  • This modifications influence the binding of chromatin-associated proteins and result in gene activation or suppression.
  • Some enzymes that catalyze this reaction continue to generate a trimethylated form; these enzymes are classified under EC 2.1.1.354.
  • Formerly EC 2.1.1.43.
Cross-references
BRENDA2.1.1.364
EC2PDB2.1.1.364
ExplorEnz2.1.1.364
PRIAM enzyme-specific profiles2.1.1.364
KEGG Ligand Database for Enzyme Nomenclature2.1.1.364
IUBMB Enzyme Nomenclature2.1.1.364
IntEnz2.1.1.364
MEDLINEFind literature relating to 2.1.1.364
MetaCyc2.1.1.364
Rhea expert-curated reactions2.1.1.364
UniProtKB/Swiss-Prot
Q9NVD3, SETD4_HUMAN;  P58467, SETD4_MOUSE;  Q6DHG0, SETD7_DANRE;  
Q7Z0G7, SETD7_HALRO;  Q8WTS6, SETD7_HUMAN;  Q8VHL1, SETD7_MOUSE;  
Q4QQN5, SETD7_XENTR;  

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