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ENZYME

ENZYME entry: EC 2.1.1.364

Accepted Name
[histone H3]-lysine(4) N-methyltransferase
Reaction catalysed
L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine <=> H(+) + N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine
Comment(s)
  • This entry describes enzymes that catalyze a single methylation of the L-lysine(4) residue of histone H3 (H3K4), generating a monomethylated form.
  • This modifications influence the binding of chromatin-associated proteins and result in gene activation or suppression.
  • Some enzymes that catalyze this reaction continue to generate a trimethylated form; these enzymes are classified under EC 2.1.1.354.
Cross-references
BRENDA2.1.1.364
EC2PDB2.1.1.364
ExplorEnz2.1.1.364
PRIAM enzyme-specific profiles2.1.1.364
KEGG Ligand Database for Enzyme Nomenclature2.1.1.364
IUBMB Enzyme Nomenclature2.1.1.364
IntEnz2.1.1.364
MEDLINEFind literature relating to 2.1.1.364
MetaCyc2.1.1.364
Rhea expert-curated reactions2.1.1.364
UniProtKB/Swiss-Prot
Q03164, KMT2A_HUMANP55200, KMT2A_MOUSEQ9UMN6, KMT2B_HUMAN
O08550, KMT2B_MOUSEQ8NEZ4, KMT2C_HUMANQ8BRH4, KMT2C_MOUSE
O14686, KMT2D_HUMANQ6PDK2, KMT2D_MOUSEA0A163UT06, SET17_CAEEL
O15047, SET1A_HUMANE9PYH6, SET1A_MOUSEQ9UPS6, SET1B_HUMAN
Q8CFT2, SET1B_MOUSEQ9NVD3, SETD4_HUMANP58467, SETD4_MOUSE
Q6DHG0, SETD7_DANREQ7Z0G7, SETD7_HALROQ8WTS6, SETD7_HUMAN
Q8VHL1, SETD7_MOUSEQ4QQN5, SETD7_XENTRQ6K431, TRX1_ORYSJ

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