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ENZYME entry: EC 2.1.1.368

Accepted Name
[Histone H3]-lysine(9) N-dimethyltransferase.
Reaction catalysed
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine(9) <=> 2 S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6)-dimethyl-L-lysine(9)
Comment(s)
  • This entry describes several enzymes, characterized from plants, that successively methylate the L-lysine-9 residue of histone H3 (H3K9) twice, ultimately generating a dimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes.
  • Cf. EC 2.1.1.367, EC 2.1.1.366, and EC 2.1.1.355.
  • Formerly EC 2.1.1.43.
Cross-references
BRENDA2.1.1.368
EC2PDB2.1.1.368
ExplorEnz2.1.1.368
PRIAM enzyme-specific profiles2.1.1.368
KEGG Ligand Database for Enzyme Nomenclature2.1.1.368
IUBMB Enzyme Nomenclature2.1.1.368
IntEnz2.1.1.368
MEDLINEFind literature relating to 2.1.1.368
MetaCyc2.1.1.368
Rhea expert-curated reactions2.1.1.368
UniProtKB/Swiss-Prot
Q9FF80, SUVH1_ARATH;  Q93YF5, SUVH1_TOBAC;  

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