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ENZYME

ENZYME entry: EC 2.1.1.355

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.355
Accepted Name
[histone H3]-lysine(9) N-trimethyltransferase
Reaction catalysed
L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)
Comment(s)
  • This entry describes several enzymes that successively methylate the L-lysine(9) residue of histone H3 (H3K9), ultimately generating a trimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.366, EC 2.1.1.367 and EC 2.1.1.368.
Cross-references
BRENDA2.1.1.355
EC2PDB2.1.1.355
ExplorEnz2.1.1.355
KEGG Ligand Database for Enzyme Nomenclature2.1.1.355
IUBMB Enzyme Nomenclature2.1.1.355
MEDLINEFind literature relating to 2.1.1.355
MetaCyc2.1.1.355
Rhea expert-curated reactions2.1.1.355
UniProtKB/Swiss-Prot
O60016, CLR4_SCHPOQ8X225, DIM5_NEUCRA0A1L7TZE5, KMT1_FUSMA
Q13029, PRDM2_HUMANQ63755, PRDM2_RATQ6P2A1, PRDM9_DANRE
Q9NQV7, PRDM9_HUMANQ96EQ9, PRDM9_MOUSEP0C6Y7, PRDM9_RAT
Q9U263, SET26_CAEELQ32KD2, SETB1_DROMEQ28Z18, SETB1_DROPS
P45975, SUV39_DROMEQ294B9, SUV39_DROPSP20659, TRX_DROME
Q24742, TRX_DROVI

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