ENZYME entry: EC 2.1.1.355
Accepted Name |
[Histone H3]-lysine(9) N-trimethyltransferase.
|
Reaction catalysed |
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine(9) <=> 3 S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(9) |
Comment(s) |
- This entry describes several enzymes that successively methylate the
L-lysine(9) residue of histone H3 (H3K9), ultimately generating a
trimethylated form.
- These modifications influence the binding of chromatin-associated
proteins.
- In general, the methylation of H3K9 leads to transcriptional
repression of the affected target genes.
- Cf. EC 2.1.1.367, EC 2.1.1.368 and EC 2.1.1.366.
- Formerly EC 2.1.1.43.
|
Cross-references |
BRENDA | 2.1.1.355 |
EC2PDB | 2.1.1.355 |
ExplorEnz | 2.1.1.355 |
PRIAM enzyme-specific profiles | 2.1.1.355 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.355 |
IUBMB Enzyme Nomenclature | 2.1.1.355 |
IntEnz | 2.1.1.355 |
MEDLINE | Find literature relating to 2.1.1.355 |
MetaCyc | 2.1.1.355 |
Rhea expert-curated reactions | 2.1.1.355 |
UniProtKB/Swiss-Prot |
O60016, CLR4_SCHPO; | Q8X225, DIM5_NEUCR; | Q13029, PRDM2_HUMAN; |
Q63755, PRDM2_RAT; | Q6P2A1, PRDM9_DANRE; | Q9NQV7, PRDM9_HUMAN; |
Q96EQ9, PRDM9_MOUSE; | P0C6Y7, PRDM9_RAT; | Q9U263, SET26_CAEEL; |
Q32KD2, SETB1_DROME; | Q28Z18, SETB1_DROPS; | P45975, SUV39_DROME; |
Q294B9, SUV39_DROPS; | Q2NL30, SUV91_BOVIN; | O43463, SUV91_HUMAN; |
O54864, SUV91_MOUSE; | Q5RB81, SUV91_PONAB; | Q6NRE8, SUV91_XENLA; |
Q32PH7, SUV92_BOVIN; | Q5F3W5, SUV92_CHICK; | Q9H5I1, SUV92_HUMAN; |
Q4R3E0, SUV92_MACFA; | Q9EQQ0, SUV92_MOUSE; | Q28CQ7, SUV92_XENTR; |
P20659, TRX_DROME; | Q24742, TRX_DROVI; |
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