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ENZYME entry: EC 2.1.1.355

Accepted Name
[histone H3]-lysine(9) N-trimethyltransferase.
Reaction catalysed
L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine
Comment(s)
  • This entry describes several enzymes that successively methylate the L-lysine(9) residue of histone H3 (H3K9), ultimately generating a trimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes.
  • Cf. EC 2.1.1.367, EC 2.1.1.368 and EC 2.1.1.366.
Cross-references
BRENDA2.1.1.355
EC2PDB2.1.1.355
ExplorEnz2.1.1.355
PRIAM enzyme-specific profiles2.1.1.355
KEGG Ligand Database for Enzyme Nomenclature2.1.1.355
IUBMB Enzyme Nomenclature2.1.1.355
IntEnz2.1.1.355
MEDLINEFind literature relating to 2.1.1.355
MetaCyc2.1.1.355
Rhea expert-curated reactions2.1.1.355
UniProtKB/Swiss-Prot
O60016, CLR4_SCHPO;  Q8X225, DIM5_NEUCR;  Q13029, PRDM2_HUMAN;  
Q63755, PRDM2_RAT;  Q6P2A1, PRDM9_DANRE;  Q9NQV7, PRDM9_HUMAN;  
Q96EQ9, PRDM9_MOUSE;  P0C6Y7, PRDM9_RAT;  Q9U263, SET26_CAEEL;  
Q32KD2, SETB1_DROME;  Q28Z18, SETB1_DROPS;  P45975, SUV39_DROME;  
Q294B9, SUV39_DROPS;  Q2NL30, SUV91_BOVIN;  O43463, SUV91_HUMAN;  
O54864, SUV91_MOUSE;  Q5RB81, SUV91_PONAB;  Q6NRE8, SUV91_XENLA;  
Q32PH7, SUV92_BOVIN;  Q5F3W5, SUV92_CHICK;  Q9H5I1, SUV92_HUMAN;  
Q4R3E0, SUV92_MACFA;  Q9EQQ0, SUV92_MOUSE;  Q28CQ7, SUV92_XENTR;  
P20659, TRX_DROME;  Q24742, TRX_DROVI;  

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