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ENZYME

ENZYME entry: EC 2.1.1.355

Accepted Name
[histone H3]-lysine(9) N-trimethyltransferase
Reaction catalysed
L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine <=> 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-homocysteine
Comment(s)
  • This entry describes several enzymes that successively methylate the L-lysine(9) residue of histone H3 (H3K9), ultimately generating a trimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.
  • In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.366, EC 2.1.1.367 and EC 2.1.1.368.
Cross-references
BRENDA2.1.1.355
EC2PDB2.1.1.355
ExplorEnz2.1.1.355
PRIAM enzyme-specific profiles2.1.1.355
KEGG Ligand Database for Enzyme Nomenclature2.1.1.355
IUBMB Enzyme Nomenclature2.1.1.355
IntEnz2.1.1.355
MEDLINEFind literature relating to 2.1.1.355
MetaCyc2.1.1.355
Rhea expert-curated reactions2.1.1.355
UniProtKB/Swiss-Prot
O60016, CLR4_SCHPOQ8X225, DIM5_NEUCRQ13029, PRDM2_HUMAN
Q63755, PRDM2_RATQ6P2A1, PRDM9_DANREQ9NQV7, PRDM9_HUMAN
Q96EQ9, PRDM9_MOUSEP0C6Y7, PRDM9_RATQ9U263, SET26_CAEEL
Q32KD2, SETB1_DROMEQ28Z18, SETB1_DROPSP45975, SUV39_DROME
Q294B9, SUV39_DROPSQ2NL30, SUV91_BOVINO43463, SUV91_HUMAN
O54864, SUV91_MOUSEQ5RB81, SUV91_PONABQ6NRE8, SUV91_XENLA
Q32PH7, SUV92_BOVINQ5F3W5, SUV92_CHICKQ9H5I1, SUV92_HUMAN
Q4R3E0, SUV92_MACFAQ9EQQ0, SUV92_MOUSEQ28CQ7, SUV92_XENTR
P20659, TRX_DROMEQ24742, TRX_DROVI

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