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ENZYME entry: EC 2.1.1.366

Accepted Name
[Histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + a [histone H3]-N(6),N(6)-dimethyl-L-lysine(9) <=> S-adenosyl-L-homocysteine + a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(9)
Comment(s)
  • The enzyme methylates only dimethylated lysine(9) of histone H3 (H3K9), forming the trimethylated form.
  • This modification influences the binding of chromatin-associated proteins.
  • In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes.
  • The enzyme is highly up-regulated in Huntington disease patients.
  • Cf. EC 2.1.1.367, EC 2.1.1.368, and EC 2.1.1.355.
  • Formerly EC 2.1.1.43.
Cross-references
BRENDA2.1.1.366
EC2PDB2.1.1.366
ExplorEnz2.1.1.366
PRIAM enzyme-specific profiles2.1.1.366
KEGG Ligand Database for Enzyme Nomenclature2.1.1.366
IUBMB Enzyme Nomenclature2.1.1.366
IntEnz2.1.1.366
MEDLINEFind literature relating to 2.1.1.366
MetaCyc2.1.1.366
Rhea expert-curated reactions2.1.1.366
UniProtKB/Swiss-Prot
O17679, SET6_CAEEL;  Q15047, SETB1_HUMAN;  O88974, SETB1_MOUSE;  
Q6INA9, SETB1_XENLA;  

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