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ENZYME entry: EC 2.1.1.69

Accepted Name
5-hydroxyfuranocoumarin 5-O-methyltransferase.
Alternative Name(s)
bergaptol 5-O-methyltransferase.
bergaptol methyltransferase.
bergaptol O-methyltransferase.
BMT.
furanocoumarin 5-methyltransferase.
furanocoumarin 5-O-methyltransferase.
Reaction catalysed
  • a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine
  • bergaptol + S-adenosyl-L-methionine <=> bergapten + S-adenosyl-L-homocysteine
Comment(s)
  • Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities.
  • Methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin, but has little activity on non-coumarin phenols; caffeate, 5-hydroxyferulate and daphnetin are not substrates.
  • Cu(2+), Zn(2+) and Co(2+) cause enzyme inhibition.
  • See also EC 2.1.1.70.
  • Formerly EC 2.1.1.92.
Cross-references
BRENDA2.1.1.69
EC2PDB2.1.1.69
ExplorEnz2.1.1.69
PRIAM enzyme-specific profiles2.1.1.69
KEGG Ligand Database for Enzyme Nomenclature2.1.1.69
IUBMB Enzyme Nomenclature2.1.1.69
IntEnz2.1.1.69
MEDLINEFind literature relating to 2.1.1.69
MetaCyc2.1.1.69
Rhea expert-curated reactions2.1.1.69
UniProtKB/Swiss-Prot
Q6T1F6, BMT_AMMMJ;  A8J6X1, BMT_GLELI;  A0A166U5H3, BMT_PEUPR;  
A0A4P8DY91, COMTS_PEUPR;  

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