Expasy logo

ENZYME

ENZYME entry: EC 2.1.1.69

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.69
Accepted Name
5-hydroxyfuranocoumarin 5-O-methyltransferase
Alternative Name(s)
bergaptol 5-O-methyltransferase
bergaptol methyltransferase
bergaptol O-methyltransferase
BMT
furanocoumarin 5-methyltransferase
furanocoumarin 5-O-methyltransferase
Reaction catalysed
  • a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine = a 5-methoxyfurocoumarin + S-adenosyl-L-homocysteine + H(+)
  • bergaptol + S-adenosyl-L-methionine = bergapten + S-adenosyl-L-homocysteine
Comment(s)
  • Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities.
  • Methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin, but has little activity on non-coumarin phenols; caffeate, 5-hydroxyferulate and daphnetin are not substrates.
  • Cu(2+), Zn(2+) and Co(2+) cause enzyme inhibition.
  • See also EC 2.1.1.70.
  • Formerly EC 2.1.1.92.
Cross-references
Rhea expert-curated reactions2.1.1.69
ExplorEnz2.1.1.69
IUBMB Enzyme Nomenclature2.1.1.69
UniProtKB/Swiss-Prot
Q6T1F6, BMT_AMMMJA8J6X1, BMT_GLELIA0A166U5H3, BMT_KITPR
A0A4P8DY91, COMTS_KITPR
BRENDA2.1.1.69
MetaCyc2.1.1.69
KEGG Ligand Database for Enzyme Nomenclature2.1.1.69
EC2PDB2.1.1.69
MEDLINEFind literature relating to 2.1.1.69

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-