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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
5-hydroxyfuranocoumarin 5-O-methyltransferase.
Alternative Name(s)
Bergaptol 5-O-methyltransferase.
Bergaptol methyltransferase.
Bergaptol O-methyltransferase.
Furanocoumarin 5-methyltransferase.
Furanocoumarin 5-O-methyltransferase.
Reaction catalysed
  • S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin <=> S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin
  • S-adenosyl-L-methionine + bergaptol <=> S-adenosyl-L-homocysteine + bergapten
  • Converts bergaptol into bergapten, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities.
  • Methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin, but has little activity on non-coumarin phenols; caffeate, 5-hydroxyferulate and daphnetin are not substrates.
  • Cu(2+), Zn(2+) and Co(2+) cause enzyme inhibition.
  • See also EC
  • Formerly EC
PRIAM enzyme-specific profiles2.1.1.69
KEGG Ligand Database for Enzyme Nomenclature2.1.1.69
IUBMB Enzyme Nomenclature2.1.1.69
MEDLINEFind literature relating to

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