ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.1.1.70

Accepted Name
8-hydroxyfuranocoumarin 8-O-methyltransferase.
Alternative Name(s)
Furanocoumarin 8-methyltransferase.
Furanocoumarin 8-O-methyl-transferase.
Xanthotoxol 8-O-methyltransferase.
XMT.
Reaction catalysed
S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin <=> S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin S-adenosyl-L-methionine + xanthotoxol <=> S-adenosyl-L-homocysteine + xanthotoxin
Comment(s)
Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols. See also EC 2.1.1.69. Formerly EC 2.1.1.93.
Cross-references
BRENDA	2.1.1.70
EC2PDB	2.1.1.70
ExplorEnz	2.1.1.70
PRIAM enzyme-specific profiles	2.1.1.70
KEGG Ligand Database for Enzyme Nomenclature	2.1.1.70
IUBMB Enzyme Nomenclature	2.1.1.70
IntEnz	2.1.1.70
MEDLINE	Find literature relating to 2.1.1.70
MetaCyc	2.1.1.70

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