Home  |  Contact

ENZYME entry: EC 2.1.1.70

Accepted Name
8-hydroxyfuranocoumarin 8-O-methyltransferase.
Alternative Name(s)
furanocoumarin 8-methyltransferase.
furanocoumarin 8-O-methyl-transferase.
xanthotoxol 8-O-methyltransferase.
XMT.
Reaction catalysed
  • an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine
  • S-adenosyl-L-methionine + xanthotoxol <=> H(+) + S-adenosyl-L-homocysteine + xanthotoxin
Comment(s)
  • Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities.
  • Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols.
  • See also EC 2.1.1.69.
  • Formerly EC 2.1.1.93.
Cross-references
BRENDA2.1.1.70
EC2PDB2.1.1.70
ExplorEnz2.1.1.70
PRIAM enzyme-specific profiles2.1.1.70
KEGG Ligand Database for Enzyme Nomenclature2.1.1.70
IUBMB Enzyme Nomenclature2.1.1.70
IntEnz2.1.1.70
MEDLINEFind literature relating to 2.1.1.70
MetaCyc2.1.1.70
Rhea expert-curated reactions2.1.1.70
UniProtKB/Swiss-Prot
A0A4P8DY91, COMTS_PEUPR

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-