ENZYME entry: EC 2.1.1.70
| Accepted Name |
|---|
| 8-hydroxyfuranocoumarin 8-O-methyltransferase.
|
| Alternative Name(s) |
|---|
| Furanocoumarin 8-methyltransferase. |
| Furanocoumarin 8-O-methyl-transferase. |
| Xanthotoxol 8-O-methyltransferase. |
| XMT. |
| Reaction catalysed |
|---|
- S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin <=> S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin
- S-adenosyl-L-methionine + xanthotoxol <=> S-adenosyl-L-homocysteine + xanthotoxin
|
| Comment(s) |
|---|
- Converts xanthotoxol into xanthotoxin, which has therapeutic
potential in the treatment of psoriasis as it has photosensitizing
and antiproliferative activities.
- Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins,
but has little activity on non-coumarin phenols.
- See also EC 2.1.1.69.
- Formerly EC 2.1.1.93.
|
| Cross-references |
|---|
| BRENDA | 2.1.1.70 |
| EC2PDB | 2.1.1.70 |
| ExplorEnz | 2.1.1.70 |
| PRIAM enzyme-specific profiles | 2.1.1.70 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.70 |
| IUBMB Enzyme Nomenclature | 2.1.1.70 |
| IntEnz | 2.1.1.70 |
| MEDLINE | Find literature relating to 2.1.1.70 |
| MetaCyc | 2.1.1.70 |
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UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
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