A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.1.1.70
Accepted Name |
8-hydroxyfuranocoumarin 8-O-methyltransferase.
|
Alternative Name(s) |
Furanocoumarin 8-methyltransferase. |
Furanocoumarin 8-O-methyl-transferase. |
Xanthotoxol 8-O-methyltransferase. |
XMT. |
Reaction catalysed |
- S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin <=> S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin
- S-adenosyl-L-methionine + xanthotoxol <=> S-adenosyl-L-homocysteine + xanthotoxin
|
Comment(s) |
- Converts xanthotoxol into xanthotoxin, which has therapeutic
potential in the treatment of psoriasis as it has photosensitizing
and antiproliferative activities.
- Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins,
but has little activity on non-coumarin phenols.
- See also EC 2.1.1.69.
- Formerly EC 2.1.1.93.
|
Cross-references |
BRENDA | 2.1.1.70 |
EC2PDB | 2.1.1.70 |
ExplorEnz | 2.1.1.70 |
PRIAM enzyme-specific profiles | 2.1.1.70 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.70 |
IUBMB Enzyme Nomenclature | 2.1.1.70 |
IntEnz | 2.1.1.70 |
MEDLINE | Find literature relating to 2.1.1.70 |
MetaCyc | 2.1.1.70 |
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All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-