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ENZYME

ENZYME entry: EC 2.1.1.70

Accepted Name
8-hydroxyfuranocoumarin 8-O-methyltransferase
Alternative Name(s)
furanocoumarin 8-methyltransferase
furanocoumarin 8-O-methyl-transferase
xanthotoxol 8-O-methyltransferase
XMT
Reaction catalysed
  • an 8-hydroxyfurocoumarin + S-adenosyl-L-methionine <=> an 8-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine
  • S-adenosyl-L-methionine + xanthotoxol <=> H(+) + S-adenosyl-L-homocysteine + xanthotoxin
Comment(s)
  • Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities.
  • Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols.
  • See also EC 2.1.1.69.
  • Formerly EC 2.1.1.93.
Cross-references
BRENDA2.1.1.70
EC2PDB2.1.1.70
ExplorEnz2.1.1.70
PRIAM enzyme-specific profiles2.1.1.70
KEGG Ligand Database for Enzyme Nomenclature2.1.1.70
IUBMB Enzyme Nomenclature2.1.1.70
IntEnz2.1.1.70
MEDLINEFind literature relating to 2.1.1.70
MetaCyc2.1.1.70
Rhea expert-curated reactions2.1.1.70
UniProtKB/Swiss-Prot
A0A4P8DY91, COMTS_KITPR

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