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ENZYME

ENZYME entry: EC 2.1.2.10

Accepted Name
aminomethyltransferase
Alternative Name(s)
glycine-cleavage system T-protein
glycine synthase
tetrahydrofolate aminomethyltransferase
Reaction catalysed
(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] <=> (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)
Comment(s)
  • A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase.
  • The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
Cross-references
BRENDA2.1.2.10
EC2PDB2.1.2.10
ExplorEnz2.1.2.10
PRIAM enzyme-specific profiles2.1.2.10
KEGG Ligand Database for Enzyme Nomenclature2.1.2.10
IUBMB Enzyme Nomenclature2.1.2.10
IntEnz2.1.2.10
MEDLINEFind literature relating to 2.1.2.10
MetaCyc2.1.2.10
Rhea expert-curated reactions2.1.2.10
UniProtKB/Swiss-Prot
C1F933, GCST_ACIC5A0KJ03, GCST_AERHHQ9YBA2, GCST_AERPE
A4SP35, GCST_AERS4Q0VLA6, GCST_ALCBSQ5WF30, GCST_ALKCK
A6TMY6, GCST_ALKMQA8MEG4, GCST_ALKOOB4RSJ5, GCST_ALTMD
B7GH71, GCST_ANOFWO67441, GCST_AQUAEO65396, GCST_ARATH
C3P8D5, GCST_BACAAC3LKQ4, GCST_BACACA0RIL1, GCST_BACAH
Q81M06, GCST_BACANB7JMV1, GCST_BACC0Q730W1, GCST_BACC1
B7IXL4, GCST_BACC2C1ERV0, GCST_BACC3B7HBA0, GCST_BACC4
B7HNZ1, GCST_BACC7A7GSN8, GCST_BACCNB9IXL9, GCST_BACCQ
Q818M3, GCST_BACCRQ634V6, GCST_BACCZQ5LFT6, GCST_BACFN
Q64WS3, GCST_BACFRQ6HDT6, GCST_BACHKQ65HF9, GCST_BACLD
A9VH12, GCST_BACMKA8FF41, GCST_BACP2P54378, GCST_BACSU
Q89YZ6, GCST_BACTNA7Z6M4, GCST_BACVZQ6MQ03, GCST_BDEBA
Q2KYM2, GCST_BORA1Q7WP31, GCST_BORBRQ7W1C6, GCST_BORPA
A9I7L6, GCST_BORPDQ7W0E5, GCST_BORPEP25285, GCST_BOVIN
B1YQQ3, GCST_BURA4B4EF28, GCST_BURCJQ39KT9, GCST_BURL3
A9ACU5, GCST_BURM1A3MQP5, GCST_BURM7A2S6F4, GCST_BURM9
Q62FM9, GCST_BURMAB1JSZ4, GCST_BURO0A3P0U5, GCST_BURP0
A3NEZ8, GCST_BURP6Q63PL4, GCST_BURPSA4JA71, GCST_BURVG
Q8RCV9, GCST_CALS4Q9TSZ7, GCST_CANLFQ3AET7, GCST_CARHZ
B3PI82, GCST_CELJUP28337, GCST_CHICKQ3AQ17, GCST_CHLCH
B3EFX7, GCST_CHLL2Q3B5U7, GCST_CHLL3B3QLF1, GCST_CHLP8
A1BI02, GCST_CHLPDA4SDB4, GCST_CHLPMB3QV24, GCST_CHLT3
Q8KBJ9, GCST_CHLTEQ7NSJ3, GCST_CHRVOA8APB4, GCST_CITK8
A7FRV3, GCST_CLOB1C3L1M5, GCST_CLOB6C1FTW3, GCST_CLOBJ
B1IEV3, GCST_CLOBKA7GB83, GCST_CLOBLB1KWD5, GCST_CLOBM
Q486J8, GCST_COLP3C3PHK3, GCST_CORA7Q4JXU5, GCST_CORJK
Q83B06, GCST_COXBUA7MR82, GCST_CROS8Q1LHM4, GCST_CUPMC
Q0K5P5, GCST_CUPNHQ46VZ7, GCST_CUPPJB3R7J7, GCST_CUPTR
Q6A9R6, GCST_CUTAKQ47D83, GCST_DECARC1D0F7, GCST_DEIDV
B8FT33, GCST_DESHDQ24TH3, GCST_DESHYA4J2F6, GCST_DESRM
Q54DD3, GCST_DICDIA7ZR14, GCST_ECO24B7UHV3, GCST_ECO27
B7MM91, GCST_ECO45B7LF91, GCST_ECO55Q8XD32, GCST_ECO57
B5YQ97, GCST_ECO5EB7NHW6, GCST_ECO7IB7MZ57, GCST_ECO81
B7LYG9, GCST_ECO8AC5A0H7, GCST_ECOBWA8A446, GCST_ECOHS
Q8FE65, GCST_ECOL6B1IT97, GCST_ECOLCP27248, GCST_ECOLI
B7N7E8, GCST_ECOLUB6I738, GCST_ECOSEB1LDA5, GCST_ECOSM
Q1R7C6, GCST_ECOUTC5BAT2, GCST_EDWI9A4WE57, GCST_ENT38
B2VF35, GCST_ERWT9B7LPB9, GCST_ESCF3B1YLN6, GCST_EXIS2
O49849, GCST_FLAANA6GXW3, GCST_FLAPJP49363, GCST_FLAPR
O23936, GCST_FLATRQ0RFF6, GCST_FRAAAB0TZJ8, GCST_FRAP2
A8LFB7, GCST_FRASNQ14J42, GCST_FRAT1A7NAH6, GCST_FRATF
Q2A4V3, GCST_FRATHB2SFM1, GCST_FRATMA0Q585, GCST_FRATN
Q0BN73, GCST_FRATOQ5NHP0, GCST_FRATTA4IZK8, GCST_FRATW
Q5KX76, GCST_GEOKAC5D4A2, GCST_GEOSWA4IQV5, GCST_GEOTN
Q7NFJ5, GCST_GLOVIQ9K934, GCST_HALH5A1WWA3, GCST_HALHL
Q5V230, GCST_HALMAB8D1D7, GCST_HALOHB0R5Y8, GCST_HALS3
Q9HPJ7, GCST_HALSAA9B2Q5, GCST_HERA2P48728, GCST_HUMAN
Q5QVA8, GCST_IDILOA6TDR7, GCST_KLEP7Q1INT8, GCST_KORVE
Q5X8W1, GCST_LEGPAA5I9T7, GCST_LEGPCQ5ZZ93, GCST_LEGPH
Q5X0A4, GCST_LEGPLB0SGN8, GCST_LEPBAQ04PM9, GCST_LEPBJ
Q055P6, GCST_LEPBLB0SQA1, GCST_LEPBPQ72VI6, GCST_LEPIC
Q8F935, GCST_LEPINQ92C06, GCST_LISINC1L2Q4, GCST_LISMC
Q71ZX4, GCST_LISMFB8DFY0, GCST_LISMHQ8Y7D5, GCST_LISMO
A0AIE9, GCST_LISW6B1HSN7, GCST_LYSSCP93256, GCST_MESCR
Q60BW3, GCST_METCAQ2RH46, GCST_MOOTAQ8CFA2, GCST_MOUSE
A0QEZ6, GCST_MYCA1P64221, GCST_MYCBOB8ZQK6, GCST_MYCLB
O32955, GCST_MYCLEQ73YK4, GCST_MYCPAP9WN50, GCST_MYCTO
P9WN51, GCST_MYCTUA0PTP8, GCST_MYCUAQ3IN28, GCST_NATPD
B2A2T4, GCST_NATTJQ9JVP2, GCST_NEIMAQ9K0L8, GCST_NEIMB
Q0AEP7, GCST_NITECQ82WQ6, GCST_NITEUQ3JDS3, GCST_NITOC
Q5YZ49, GCST_NOCFAQ8YNF7, GCST_NOSS1Q8CXD9, GCST_OCEIH
A6L8T3, GCST_PARD8Q7TTS1, GCST_PARMWB2JJ71, GCST_PARP8
P49364, GCST_PEAQ6D976, GCST_PECASC6D8W9, GCST_PECCP
B4SED4, GCST_PELPBQ7N197, GCST_PHOLLA6L6X5, GCST_PHOV8
B2RI74, GCST_PORG3Q7MUG4, GCST_PORGIB4S437, GCST_PROA2
A3PFH6, GCST_PROM0A2C5F7, GCST_PROM1A8G7J2, GCST_PROM2
A2CDX3, GCST_PROM3A2BZ74, GCST_PROM5Q7V9I2, GCST_PROMA
B4F0N9, GCST_PROMHQ7TUI6, GCST_PROMMQ7TU18, GCST_PROMP
A2BTR9, GCST_PROMSQ46I99, GCST_PROMTQ15PU4, GCST_PSEA6
Q9HTX5, GCST_PSEAEA8F8M9, GCST_PSELTQ88CI7, GCST_PSEPK
Q88AS0, GCST_PSESMQ3IFV9, GCST_PSET1Q9UZP8, GCST_PYRAB
Q8U185, GCST_PYRFUO58888, GCST_PYRHOQ8XUA0, GCST_RALN1
B2UG80, GCST_RALPJB7K468, GCST_RIPO1Q1AR89, GCST_RUBXD
Q21NX7, GCST_SACD2A4FLG1, GCST_SACENB5F5I0, GCST_SALA4
A9MRH0, GCST_SALARQ57K60, GCST_SALCHB5FUG8, GCST_SALDC
B5QXI2, GCST_SALEPB5RE16, GCST_SALG2B4TGX5, GCST_SALHS
B4T550, GCST_SALNSQ5PJG4, GCST_SALPAA9N3N3, GCST_SALPB
C0PY28, GCST_SALPCB5BFM0, GCST_SALPKB4TV24, GCST_SALSV
P64223, GCST_SALTIP64222, GCST_SALTYO14110, GCST_SCHPO
A8GIS1, GCST_SERP5A1S967, GCST_SHEAMB8EB47, GCST_SHEB2
A3D083, GCST_SHEB5A6WSL3, GCST_SHEB8A9L332, GCST_SHEB9
Q12R04, GCST_SHEDOQ07YC7, GCST_SHEFNB0TSG7, GCST_SHEHH
A3QHI2, GCST_SHELPQ8EIQ8, GCST_SHEONA8H7T1, GCST_SHEPA
A4YAE0, GCST_SHEPCB8CK16, GCST_SHEPWA0L105, GCST_SHESA
A8FZK6, GCST_SHESHQ0HEX0, GCST_SHESMQ0HZ30, GCST_SHESR
A1RFY6, GCST_SHESWB1KG89, GCST_SHEWMB2U0S2, GCST_SHIB3
Q31WG6, GCST_SHIBSQ32BW7, GCST_SHIDSQ0T0Z3, GCST_SHIF8
Q83JU1, GCST_SHIFLQ3YXW5, GCST_SHISSQ2NRE8, GCST_SODGM
P54260, GCST_SOLTUA7X2S3, GCST_STAA1A6U208, GCST_STAA2
Q2FGI5, GCST_STAA3Q2FY33, GCST_STAA8A5IT65, GCST_STAA9
Q2YSZ2, GCST_STAABQ5HFM2, GCST_STAACA6QH81, GCST_STAAE
P64224, GCST_STAAMP64225, GCST_STAANQ6GGG2, GCST_STAAR
Q6G929, GCST_STAASA8Z476, GCST_STAATP64226, GCST_STAAW
B9DNN7, GCST_STACTQ5HP12, GCST_STAEQQ8CSF4, GCST_STAES
Q4L6N7, GCST_STAHJQ49XY1, GCST_STAS1Q82JI2, GCST_STRAW
O86567, GCST_STRCOB4SSE0, GCST_STRM5B2FR21, GCST_STRMK
Q67N36, GCST_SYMTHQ31KT1, GCST_SYNE7B1XP99, GCST_SYNP2
Q5N136, GCST_SYNP6A5GPL8, GCST_SYNPWA5GWT1, GCST_SYNR3
Q0I682, GCST_SYNS3Q3AVT0, GCST_SYNS9P54261, GCST_SYNY3
C5BM95, GCST_TERTTC5A3P0, GCST_THEGJQ5JDG3, GCST_THEKO
A6LP67, GCST_THEM4Q9WY54, GCST_THEMAB9K6R7, GCST_THENN
B6YY21, GCST_THEONA5IKL0, GCST_THEP1B0KD95, GCST_THEP3
B0K242, GCST_THEPXB1L9U1, GCST_THESQQ72LB1, GCST_THET2
Q5SKX0, GCST_THET8Q8DKV6, GCST_THEVBB8GNE2, GCST_THISH
Q8PI37, GCST_XANACQ3BQN6, GCST_XANC5Q4UXC2, GCST_XANC8
Q8P6T8, GCST_XANCPQ2P4S5, GCST_XANOMB2SSQ1, GCST_XANOP
Q5H1X3, GCST_XANORB2I6Q1, GCST_XYLF2Q9PGW5, GCST_XYLFA
B0U270, GCST_XYLFMQ87EZ6, GCST_XYLFTP48015, GCST_YEAST
A1JPN6, GCST_YERE8A7FF19, GCST_YERP3Q1CB44, GCST_YERPA
B2K0Q5, GCST_YERPBQ8ZHI6, GCST_YERPEA9R4K6, GCST_YERPG
Q1CEZ7, GCST_YERPNA4TIA5, GCST_YERPPQ666R5, GCST_YERPS
B1JNS6, GCST_YERPY

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-