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ENZYME entry: EC 2.3.1.219

Accepted Name
Demethoxycurcumin synthase.
Reaction catalysed
  • 4-coumaroyl-CoA + feruloylacetyl-CoA + H(2)O <=> 2 CoA + demethoxycurcumin + CO(2)
  • 4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H(2)O <=> 2 CoA + bisdemethoxycurcumin + CO(2)
Comment(s)
  • A polyketide synthase from the plant Curcuma longa (turmeric).
  • Three isoforms exist, CURS1, CURS2 and CURS3.
  • While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. EC 2.3.1.217), CURS3 can accept 4-coumaroyl-CoA equally well.
Cross-references
BRENDA2.3.1.219
EC2PDB2.3.1.219
ExplorEnz2.3.1.219
PRIAM enzyme-specific profiles2.3.1.219
KEGG Ligand Database for Enzyme Nomenclature2.3.1.219
IUBMB Enzyme Nomenclature2.3.1.219
IntEnz2.3.1.219
MEDLINEFind literature relating to 2.3.1.219
MetaCyc2.3.1.219
Rhea expert-curated reactions2.3.1.219
UniProtKB/Swiss-Prot
C6L7V9, CURS3_CURLO

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