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ENZYME entry: EC

Accepted Name
Very-long-chain ceramide synthase.
Alternative Name(s)
Mammalian ceramide synthase 2.
Sphingoid base N-very-long-chain fatty acyl-coA transferase.
Reaction catalysed
A very-long-chain fatty acyl-CoA + a sphingoid base <=> a very-long-chain ceramide + CoA
  • This entry describes ceramide synthase enzymes that are specific for very-long-chain fatty acyl-CoA substrates.
  • The two isoforms from yeast and the plant LOH1 and LOH3 isoforms transfer 24:0 and 26:0 acyl chains preferentially and use phytosphingosine as the preferred sphingoid base.
  • The mammalian CERS2 isoform is specific for acyl donors of 20-26 carbons, which can be saturated or unsaturated.
  • The mammalian CERS3 isoform catalyzes this activity, but has a broader substrate range and also catalyzes the activity of EC
  • Both mammalian enzymes can use multiple sphingoid bases, including sphinganine, sphingosine, and phytosphingosine.
PRIAM enzyme-specific profiles2.3.1.297
KEGG Ligand Database for Enzyme Nomenclature2.3.1.297
IUBMB Enzyme Nomenclature2.3.1.297
MEDLINEFind literature relating to
Rhea expert-curated reactions2.3.1.297

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