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ENZYME entry: EC 2.3.1.297

Accepted Name
very-long-chain ceramide synthase.
Alternative Name(s)
mammalian ceramide synthase 2.
sphingoid base N-very-long-chain fatty acyl-CoA transferase.
Reaction catalysed
a sphingoid base + a very long-chain fatty acyl-CoA <=> an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)
Comment(s)
  • This entry describes ceramide synthase enzymes that are specific for very-long-chain fatty acyl-CoA substrates.
  • The two isoforms from yeast and the plant LOH1 and LOH3 isoforms transfer 24:0 and 26:0 acyl chains preferentially and use phytosphingosine as the preferred sphingoid base.
  • The mammalian CERS2 isoform is specific for acyl donors of 20-26 carbons, which can be saturated or unsaturated.
  • The mammalian CERS3 isoform catalyzes this activity, but has a broader substrate range and also catalyzes the activity of EC 2.3.1.298.
  • Both mammalian enzymes can use multiple sphingoid bases, including sphinganine, sphingosine, and phytosphingosine.
Cross-references
BRENDA2.3.1.297
EC2PDB2.3.1.297
ExplorEnz2.3.1.297
PRIAM enzyme-specific profiles2.3.1.297
KEGG Ligand Database for Enzyme Nomenclature2.3.1.297
IUBMB Enzyme Nomenclature2.3.1.297
IntEnz2.3.1.297
MEDLINEFind literature relating to 2.3.1.297
MetaCyc2.3.1.297
Rhea expert-curated reactions2.3.1.297
UniProtKB/Swiss-Prot
Q3ZBF8, CERS2_BOVIN;  Q96G23, CERS2_HUMAN;  Q924Z4, CERS2_MOUSE;  
Q8IU89, CERS3_HUMAN;  Q1A3B0, CERS3_MOUSE;  P28496, LAC1_YEAST;  
P38703, LAG1_YEAST;  

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