Home  |  Contact

ENZYME entry: EC

Accepted Name
Ultra-long-chain ceramide synthase.
Alternative Name(s)
Mammalian ceramide synthase 3.
Sphingoid base N-ultra-long-chain fatty acyl-coA transferase.
Reaction catalysed
An ultra-long-chain fatty acyl-CoA + a sphingoid base <=> an ultra-long-chain ceramide + CoA
  • Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates.
  • Ceramide synthase 3 (CERS3) is the only enzyme that is active with ultra-long-chain acyl-CoA donors (C(28) or longer).
  • It is active in the epidermis, where its products are incorporated into acylceramides.
  • CERS3 also accepts (2R)-2-hydroxy fatty acids and omega-hydroxy fatty acids, and can accept very-long-chain acyl-CoA substrates (see EC
  • It can use multiple sphingoid bases including sphinganine, sphingosine, phytosphingosine, and (6R)-6-hydroxysphingosine.
PRIAM enzyme-specific profiles2.3.1.298
KEGG Ligand Database for Enzyme Nomenclature2.3.1.298
IUBMB Enzyme Nomenclature2.3.1.298
MEDLINEFind literature relating to
Rhea expert-curated reactions2.3.1.298

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-