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ENZYME

ENZYME entry: EC 2.3.1.298

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.298
Accepted Name
ultra-long-chain ceramide synthase
Alternative Name(s)
mammalian ceramide synthase 3
sphingoid base N-ultra-long-chain fatty acyl-CoA transferase
Reaction catalysed
an ultra-long-chain fatty acyl-CoA + a sphingoid base = an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)
Comment(s)
  • Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates.
  • Ceramide synthase 3 (CERS3) is the only enzyme that is active with ultra-long-chain acyl-CoA donors (C28 or longer).
  • It is active in the epidermis, where its products are incorporated into acylceramides.
  • CERS3 also accepts (2R)-2-hydroxy fatty acids and omega-hydroxy fatty acids, and can accept very-long-chain acyl-CoA substrates (see EC 2.3.1.297).
  • It can use multiple sphingoid bases including sphinganine, sphingosine, phytosphingosine, and (6R)-6-hydroxysphingosine.
Cross-references
BRENDA2.3.1.298
EC2PDB2.3.1.298
ExplorEnz2.3.1.298
KEGG Ligand Database for Enzyme Nomenclature2.3.1.298
IUBMB Enzyme Nomenclature2.3.1.298
MEDLINEFind literature relating to 2.3.1.298
MetaCyc2.3.1.298
Rhea expert-curated reactions2.3.1.298
UniProtKB/Swiss-Prot
Q8IU89, CERS3_HUMANQ1A3B0, CERS3_MOUSE

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