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ENZYME entry: EC 2.3.1.300

Accepted Name
branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase.
Reaction catalysed
  • 3-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> 5-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA
  • 2-methylpropanoyl-CoA + H(+) + malonyl-[ACP] <=> 4-methyl-3-oxopentanoyl-[ACP] + CO2 + CoA
  • (2S)-2-methylbutanoyl-CoA + H(+) + malonyl-[ACP] <=> (4S)-4-methyl-3-oxohexanoyl-[ACP] + CO2 + CoA
Comment(s)
  • The enzyme is responsible for initiating branched-chain fatty acid biosynthesis by the dissociated (or type II) fatty-acid biosynthesis system (FAS-II) in some bacteria, using molecules derived from degradation of the branched-chain amino acids L-leucine, L-valine, and L-isoleucine to form the starting molecules for elongation by the FAS-II system.
  • In some organisms the enzyme is also able to use acetyl-CoA, leading to production of a mix of branched-chain and straight-chain fatty acids (cf. EC 2.3.1.180).
Cross-references
BRENDA2.3.1.300
EC2PDB2.3.1.300
ExplorEnz2.3.1.300
PRIAM enzyme-specific profiles2.3.1.300
KEGG Ligand Database for Enzyme Nomenclature2.3.1.300
IUBMB Enzyme Nomenclature2.3.1.300
IntEnz2.3.1.300
MEDLINEFind literature relating to 2.3.1.300
MetaCyc2.3.1.300
Rhea expert-curated reactions2.3.1.300
UniProtKB/Swiss-Prot
O34746, FABH1_BACSU;  O07600, FABH2_BACSU;  P0DW99, FABH_CUTAC;  
C0LNR0, FABH_LISM4;  Q54206, FABH_STRGA;  Q9F6D4, FABH_STRLI;  
P0A3C5, FABH_STRPN;  Q4URQ0, FABH_XANC8;  

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