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ENZYME entry: EC 2.3.1.180

Accepted Name
Beta-ketoacyl-[acyl-carrier-protein] synthase III.
Alternative Name(s)
3-ketoacyl-acyl carrier protein synthase III.
3-oxoacyl:ACP synthase III.
Beta-ketoacyl (acyl carrier protein) synthase III.
Beta-ketoacyl-ACP synthase III.
Beta-ketoacyl-acyl carrier protein synthase III.
KAS III.
KASIII.
Reaction catalysed
Acetyl-CoA + malonyl-[acyl-carrier-protein] <=> acetoacetyl-[acyl-carrier-protein] + CoA + CO(2)
Comment(s)
  • Involved in the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria.
  • In contrast to EC 2.3.1.41 and EC 2.3.1.179, this enzyme specifically uses CoA thioesters rather than acyl-ACP as the primer.
  • In addition to the above reaction, the enzyme can also catalyze the reaction of EC 2.3.1.38, but to a much lesser extent.
  • Responsible for initiating both straight- and branched-chain fatty- acid biosynthesis, with the substrate specificity in an organism reflecting the fatty-acid composition found in that organism.
  • For example, Streptococcus pneumoniae, a Gram-positive bacterium, is able to use both straight- and branched-chain (C4--C6) acyl-CoA primers whereas Escherichia coli, a Gram-negative organism, uses primarily short straight-chain acyl CoAs, with a preference for acetyl-CoA.
Cross-references
BRENDA2.3.1.180
EC2PDB2.3.1.180
ExplorEnz2.3.1.180
PRIAM enzyme-specific profiles2.3.1.180
KEGG Ligand Database for Enzyme Nomenclature2.3.1.180
IUBMB Enzyme Nomenclature2.3.1.180
IntEnz2.3.1.180
MEDLINEFind literature relating to 2.3.1.180
MetaCyc2.3.1.180
UniProtKB/Swiss-Prot
Q81JG0, FABH1_BACAN;  Q81GM0, FABH1_BACCR;  Q9K8W9, FABH1_BACHD;  
O34746, FABH1_BACSU;  Q8ABI8, FABH1_BACTN;  P49244, FABH1_CUPWR;  
Q9RT23, FABH1_DEIRA;  Q88YZ4, FABH1_LACPL;  Q8CPT4, FABH1_STAES;  
Q82BB8, FABH1_STRAW;  P72392, FABH1_STRCO;  Q9KQH5, FABH1_VIBCH;  
Q87N20, FABH1_VIBPA;  Q8D8G6, FABH1_VIBVU;  Q7M7J9, FABH1_VIBVY;  
Q81JF6, FABH2_BACAN;  Q81F42, FABH2_BACCR;  Q9KET5, FABH2_BACHD;  
O07600, FABH2_BACSU;  Q8A137, FABH2_BACTN;  P49245, FABH2_CUPWR;  
Q9RT22, FABH2_DEIRA;  Q88WG8, FABH2_LACPL;  Q8CUB8, FABH2_STAES;  
Q82M29, FABH2_STRAW;  Q9Z4Y5, FABH2_STRCO;  Q9KLJ3, FABH2_VIBCH;  
Q87HJ2, FABH2_VIBPA;  Q8D719, FABH2_VIBVU;  Q7M7I3, FABH2_VIBVY;  
O54151, FABH3_STRCO;  Q9ZBV4, FABH4_STRCO;  Q9JN82, FABH5_STRCO;  
Q9PMZ6, FABHL_CAMJE;  B0CE67, FABH_ACAM1;  A9NFF0, FABH_ACHLI;  
A1TLD7, FABH_ACIAC;  A5FV65, FABH_ACICJ;  B9MDQ9, FABH_ACIET;  
A1WAX8, FABH_ACISJ;  A3N232, FABH_ACTP2;  A6VQV2, FABH_ACTSZ;  
Q8UG62, FABH_AGRFC;  B9JCY9, FABH_AGRRK;  B9JV87, FABH_AGRVS;  
Q5E409, FABH_ALIF1;  Q0A8R5, FABH_ALKEH;  Q5PA98, FABH_ANAMM;  
O67185, FABH_AQUAE;  P49243, FABH_ARATH;  A8ERJ6, FABH_ARCB4;  
Q5P0D6, FABH_AROAE;  B6YS41, FABH_AZOPC;  A1K5Y5, FABH_AZOSB;  
A8FBX4, FABH_BACP2;  A6KXK3, FABH_BACV8;  A1USI9, FABH_BARBK;  
Q6G3K4, FABH_BARHE;  Q6G000, FABH_BARQU;  A9IVB4, FABH_BART1;  
Q1LT37, FABH_BAUCH;  Q7VR18, FABH_BLOFL;  Q492Q4, FABH_BLOPB;  
Q2KUK5, FABH_BORA1;  Q7WD20, FABH_BORBR;  Q7W5I4, FABH_BORPA;  
A9IIH4, FABH_BORPD;  Q7VW29, FABH_BORPE;  Q89K89, FABH_BRADU;  
A5EKG5, FABH_BRASB;  A4YW84, FABH_BRASO;  B2S524, FABH_BRUA1;  
Q2YNB9, FABH_BRUA2;  Q57DX4, FABH_BRUAB;  A9MAF6, FABH_BRUC2;  
C0RIB3, FABH_BRUMB;  Q8YGH9, FABH_BRUME;  A5VPV8, FABH_BRUO2;  
B0CLA2, FABH_BRUSI;  Q8G1E0, FABH_BRUSU;  Q1BXV4, FABH_BURCA;  
B1JYA0, FABH_BURCC;  A0K5U6, FABH_BURCH;  Q39I86, FABH_BURL3;  
A3MM55, FABH_BURM7;  A2S9Y2, FABH_BURM9;  Q62LU2, FABH_BURMA;  
A1V6D0, FABH_BURMS;  A3NXM9, FABH_BURP0;  Q3JQ65, FABH_BURP1;  
A3NBU2, FABH_BURP6;  Q63S83, FABH_BURPS;  Q2SXU7, FABH_BURTA;  
A4JCP8, FABH_BURVG;  Q8R9V7, FABH_CALS4;  A4XJW0, FABH_CALS8;  
A7ZC01, FABH_CAMC1;  A7H054, FABH_CAMC5;  A0RMK8, FABH_CAMFF;  
A7I3D6, FABH_CAMHC;  A8FKB7, FABH_CAMJ8;  A7H541, FABH_CAMJD;  
Q9PIH1, FABH_CAMJE;  A1VY47, FABH_CAMJJ;  Q5HWE3, FABH_CAMJR;  
Q9A8I4, FABH_CAUVC;  Q11J83, FABH_CHESB;  Q3AQ09, FABH_CHLCH;  
Q820E6, FABH_CHLCV;  Q9PKF5, FABH_CHLMU;  A1BJA1, FABH_CHLPD;  
A4SCL4, FABH_CHLPM;  Q9Z8P0, FABH_CHLPN;  Q3KMC3, FABH_CHLTA;  
Q8KAP2, FABH_CHLTE;  O84242, FABH_CHLTR;  Q7NSK7, FABH_CHRVO;  
A8AHY1, FABH_CITK8;  Q97DA2, FABH_CLOAB;  A7FPM6, FABH_CLOB1;  
C3KWF7, FABH_CLOB6;  A6LSC2, FABH_CLOB8;  A5I7X8, FABH_CLOBH;  
C1FNK7, FABH_CLOBJ;  B1IHN1, FABH_CLOBK;  A7GJJ9, FABH_CLOBL;  
B1KU74, FABH_CLOBM;  B9DY04, FABH_CLOK1;  A5N4E1, FABH_CLOK5;  
A0PXB6, FABH_CLONN;  Q0TRH0, FABH_CLOP1;  Q8XLH3, FABH_CLOPE;  
Q0STU9, FABH_CLOPS;  Q899P3, FABH_CLOTE;  B6J8E5, FABH_COXB1;  
B6J1I6, FABH_COXB2;  A9KEA1, FABH_COXBN;  A9NBY3, FABH_COXBR;  
Q820X0, FABH_COXBU;  A7MFQ4, FABH_CROS8;  Q0K8L9, FABH_CUPNH;  
Q46Z05, FABH_CUPPJ;  B3R213, FABH_CUPTR;  C1D0N4, FABH_DEIDV;  
Q1J198, FABH_DEIGD;  A9BNK6, FABH_DELAS;  Q30YM1, FABH_DESAG;  
B8FRS6, FABH_DESHD;  Q24U40, FABH_DESHY;  Q6AJF8, FABH_DESPS;  
Q72CS6, FABH_DESVH;  B8DJG1, FABH_DESVM;  A1VEK1, FABH_DESVV;  
A5EXD7, FABH_DICNV;  A8LLT4, FABH_DINSH;  A7ZKJ4, FABH_ECO24;  
P0A6R2, FABH_ECO57;  A7ZZ48, FABH_ECOHS;  A1A9Y5, FABH_ECOK1;  
Q0TIY3, FABH_ECOL5;  P0A6R1, FABH_ECOL6;  B1IUH4, FABH_ECOLC;  
P0A6R0, FABH_ECOLI;  Q1RD66, FABH_ECOUT;  Q3YRP7, FABH_EHRCJ;  
Q2GH17, FABH_EHRCR;  Q5FFP2, FABH_EHRRG;  Q5HAV9, FABH_EHRRW;  
A4W9A5, FABH_ENT38;  Q820T1, FABH_ENTFA;  Q2N925, FABH_ERYLH;  
Q8RGX7, FABH_FUSNN;  Q5L1U1, FABH_GEOKA;  Q7NF35, FABH_GLOVI;  
Q0BTE0, FABH_GRABC;  Q6B945, FABH_GRATL;  Q7U337, FABH_HAEDU;  
Q4QP30, FABH_HAEI8;  A5UFW1, FABH_HAEIG;  P43711, FABH_HAEIN;  
Q0I0V6, FABH_HAES1;  Q17YQ2, FABH_HELAH;  P59813, FABH_HELHP;  
B6JKD5, FABH_HELP2;  B5Z9X2, FABH_HELPG;  Q1CUV9, FABH_HELPH;  
Q9ZMN0, FABH_HELPJ;  B2US32, FABH_HELPS;  O24994, FABH_HELPY;  
A4G6T2, FABH_HERAR;  B0UUZ0, FABH_HISS2;  Q0C312, FABH_HYPNA;  
A6SXP9, FABH_JANMA;  Q28RG1, FABH_JANSC;  A6T7F1, FABH_KLEP7;  
B2GFZ7, FABH_KOCRD;  Q1IQ32, FABH_KORVE;  Q03RV2, FABH_LACBA;  
Q1GAG1, FABH_LACDA;  Q04AU8, FABH_LACDB;  A8YXS0, FABH_LACH4;  
Q9CHG0, FABH_LACLA;  A2RM32, FABH_LACLM;  Q030J8, FABH_LACLS;  
A5VK78, FABH_LACRD;  B2G7L1, FABH_LACRJ;  Q38XG4, FABH_LACSS;  
C1DCE8, FABH_LARHH;  Q929H1, FABH_LISIN;  Q71XG3, FABH_LISMF;  
Q8Y573, FABH_LISMO;  A0AKV5, FABH_LISW6;  Q2W4R7, FABH_MAGSA;  
A1U0E3, FABH_MARHV;  Q606L3, FABH_METCA;  B0JXE2, FABH_MICAN;  
A0QLF3, FABH_MYCA1;  B1MKD7, FABH_MYCA9;  P0A575, FABH_MYCBO;  
A1KG10, FABH_MYCBP;  C1AKL3, FABH_MYCBT;  B2HRM4, FABH_MYCMM;  
Q73SP5, FABH_MYCPA;  A5TZR3, FABH_MYCTA;  P9WNG2, FABH_MYCTO;  
P9WNG3, FABH_MYCTU;  A0PLS8, FABH_MYCUA;  B2A2M5, FABH_NATTJ;  
Q5F4X5, FABH_NEIG1;  B4RJI1, FABH_NEIG2;  A9M142, FABH_NEIM0;  
Q9JW56, FABH_NEIMA;  Q9JXR6, FABH_NEIMB;  A1KRY9, FABH_NEIMF;  
Q2GDD8, FABH_NEOSM;  Q0AIS4, FABH_NITEC;  Q82U60, FABH_NITEU;  
Q2YA46, FABH_NITMU;  Q8Z062, FABH_NOSS1;  Q2G5S1, FABH_NOVAD;  
Q8ERU6, FABH_OCEIH;  A6X1X8, FABH_OCHA4;  Q04DM7, FABH_OENOB;  
A6LEP7, FABH_PARD8;  A1B364, FABH_PARDP;  B2JFI9, FABH_PARP8;  
Q9CJS8, FABH_PASMU;  Q6D690, FABH_PECAS;  Q3B6K8, FABH_PELLD;  
Q18B40, FABH_PEPD6;  C0QPF4, FABH_PERMH;  Q7N384, FABH_PHOLL;  
A4SVV4, FABH_POLAQ;  A1VRU7, FABH_POLNA;  B1XTK6, FABH_POLNS;  
Q126I8, FABH_POLSJ;  B2RH63, FABH_PORG3;  Q7MAV3, FABH_PORGI;  
P51196, FABH_PORPU;  P31176, FABH_PORUM;  A3PAK3, FABH_PROM0;  
A8G2E1, FABH_PROM2;  A2BUB2, FABH_PROM5;  Q31D45, FABH_PROM9;  
Q7VE55, FABH_PROMA;  Q7V4F6, FABH_PROMM;  Q7V3E0, FABH_PROMP;  
Q46HN8, FABH_PROMT;  Q15TZ6, FABH_PSEA6;  B7V4R0, FABH_PSEA8;  
Q02QG7, FABH_PSEAB;  Q9HYR2, FABH_PSEAE;  Q3IBW0, FABH_PSEHT;  
A1STW1, FABH_PSYIN;  Q1XDU1, FABH_PYRYE;  B2U968, FABH_RALPJ;  
Q8Y0J4, FABH_RALSO;  Q1MIS6, FABH_RHIL3;  Q982Z8, FABH_RHILO;  
Q92QT4, FABH_RHIME;  P59814, FABH_RHOBA;  P30790, FABH_RHOCA;  
B6IMR5, FABH_RHOCS;  Q21XP4, FABH_RHOFT;  Q2RTS8, FABH_RHORT;  
A3PJ64, FABH_RHOS1;  Q3J365, FABH_RHOS4;  A4WTT9, FABH_RHOS5;  
A8GPW1, FABH_RICAH;  A8GY06, FABH_RICB8;  Q1RKA5, FABH_RICBR;  
A8EZX3, FABH_RICCK;  Q92GC1, FABH_RICCN;  Q4UK49, FABH_RICFE;  
A8F2R3, FABH_RICM5;  Q9ZCH1, FABH_RICPR;  B0BV80, FABH_RICRO;  
A8GTP2, FABH_RICRS;  Q68VX7, FABH_RICTY;  A7NK75, FABH_ROSCS;  
Q164C9, FABH_ROSDO;  A5UWI7, FABH_ROSS1;  Q1AW87, FABH_RUBXD;  
Q5LQJ5, FABH_RUEPO;  Q1GI69, FABH_RUEST;  A9MGC9, FABH_SALAR;  
Q57QG4, FABH_SALCH;  Q5PGU1, FABH_SALPA;  A9N5L3, FABH_SALPB;  
Q8Z7J6, FABH_SALTI;  O85139, FABH_SALTY;  A8GD17, FABH_SERP5;  
Q8EDH1, FABH_SHEON;  Q31ZE6, FABH_SHIBS;  Q32EV1, FABH_SHIDS;  
Q0T5U5, FABH_SHIF8;  Q83RS8, FABH_SHIFL;  Q3Z326, FABH_SHISS;  
A6U7Q5, FABH_SINMW;  Q2NU42, FABH_SODGM;  Q01QV9, FABH_SOLUE;  
Q1GT90, FABH_SPHAL;  A5VC86, FABH_SPHWW;  Q07510, FABH_SPIOL;  
A7X0K2, FABH_STAA1;  A6U089, FABH_STAA2;  Q2FI93, FABH_STAA3;  
Q2FZS0, FABH_STAA8;  A5IRG0, FABH_STAA9;  Q2YWV3, FABH_STAAB;  
Q5HHA2, FABH_STAAC;  A6QFJ3, FABH_STAAE;  P68795, FABH_STAAM;  
P99159, FABH_STAAN;  Q6GIA4, FABH_STAAR;  Q6GAU3, FABH_STAAS;  
A8Z088, FABH_STAAT;  Q8NXE2, FABH_STAAW;  Q5HQI2, FABH_STAEQ;  
Q4L4Z3, FABH_STAHJ;  Q49WB6, FABH_STAS1;  Q3K338, FABH_STRA1;  
P64112, FABH_STRA3;  P64113, FABH_STRA5;  C0M7U3, FABH_STRE4;  
B4U1B3, FABH_STREM;  Q54206, FABH_STRGA;  A8AYW5, FABH_STRGC;  
Q9F6D4, FABH_STRLI;  Q8DSN2, FABH_STRMU;  Q99YD2, FABH_STRP1;  
Q04M58, FABH_STRP2;  P0DB00, FABH_STRP3;  B5E7F8, FABH_STRP4;  
Q5XAE0, FABH_STRP6;  C1C5F4, FABH_STRP7;  P64115, FABH_STRP8;  
Q1JA87, FABH_STRPB;  Q1JKE0, FABH_STRPC;  Q1JFD2, FABH_STRPD;  
Q1J582, FABH_STRPF;  A2RCX0, FABH_STRPG;  B1I9L1, FABH_STRPI;  
B8ZLI3, FABH_STRPJ;  Q48RR7, FABH_STRPM;  P0A3C5, FABH_STRPN;  
P0DB01, FABH_STRPQ;  B2ILW2, FABH_STRPS;  B5XHY5, FABH_STRPZ;  
P0A3C6, FABH_STRR6;  A4W3N0, FABH_STRS2;  C0ME18, FABH_STRS7;  
A3CQ60, FABH_STRSV;  A4VXD4, FABH_STRSY;  Q5M184, FABH_STRT1;  
Q5M5S1, FABH_STRT2;  Q03M55, FABH_STRTD;  B9DVE9, FABH_STRU0;  
C1CCI2, FABH_STRZJ;  C1CIR8, FABH_STRZP;  C1CPS7, FABH_STRZT;  
Q30PN6, FABH_SULDN;  A6QBY0, FABH_SULNB;  Q67PG0, FABH_SYMTH;  
Q31N84, FABH_SYNE7;  Q5N5X5, FABH_SYNP6;  A5GP11, FABH_SYNPW;  
A5GQJ2, FABH_SYNR3;  Q0AVV3, FABH_SYNWW;  P73951, FABH_SYNY3;  
Q8DKL4, FABH_THEEB;  Q3SIM4, FABH_THIDA;  B8GSX7, FABH_THISH;  
Q114K0, FABH_TRIEI;  Q3M9J4, FABH_TRIV2;  P64117, FABH_TROW8;  
P64116, FABH_TROWT;  C5CSE2, FABH_VARPS;  A1WMX5, FABH_VEREI;  
A5CWU7, FABH_VESOH;  Q73GG9, FABH_WOLPM;  B3CML1, FABH_WOLPP;  
Q5GS22, FABH_WOLTR;  Q8PNE8, FABH_XANAC;  Q3BWI9, FABH_XANC5;  
Q4URQ0, FABH_XANC8;  Q8PBV1, FABH_XANCP;  Q2P7B9, FABH_XANOM;  
Q9PCG4, FABH_XYLFA;  Q87CL7, FABH_XYLFT;  A1JN67, FABH_YERE8;  
A7FH25, FABH_YERP3;  Q1C6M8, FABH_YERPA;  Q8ZFT7, FABH_YERPE;  
Q1CI19, FABH_YERPN;  A4TLS3, FABH_YERPP;  Q669L1, FABH_YERPS;  
Q9HU15, FABY_PSEAE;  

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