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ENZYME

ENZYME entry: EC 2.3.1.180

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.180
Accepted Name
beta-ketoacyl-[acyl-carrier-protein] synthase III
Alternative Name(s)
3-ketoacyl-acyl carrier protein synthase III
3-oxoacyl:ACP synthase III
beta-ketoacyl (acyl carrier protein) synthase III
beta-ketoacyl-ACP synthase III
beta-ketoacyl-acyl carrier protein synthase III
KASIII
KAS III
Reaction catalysed
malonyl-[ACP] + acetyl-CoA + H(+) = 3-oxobutanoyl-[ACP] + CO2 + CoA
Comment(s)
  • The enzyme is responsible for initiating straight-chain fatty acid biosynthesis by the dissociated (or type II) fatty-acid biosynthesis system that occurs in plants and bacteria.
  • In contrast to EC 2.3.1.41 and EC 2.3.1.179, this enzyme specifically uses short-chain acyl-CoA thioesters (preferably acetyl-CoA) rather than acyl-[acp] as its substrate.
  • The enzyme can also catalyze the reaction of EC 2.3.1.38, but to a much lesser extent.
  • The enzymes from some organisms (e.g. the Gram-positive bacterium Streptococcus pneumoniae) can accept branched-chain acyl-CoAs in addition to acetyl-CoA (cf. EC 2.3.1.300).
Cross-references
BRENDA2.3.1.180
EC2PDB2.3.1.180
ExplorEnz2.3.1.180
KEGG Ligand Database for Enzyme Nomenclature2.3.1.180
IUBMB Enzyme Nomenclature2.3.1.180
MEDLINEFind literature relating to 2.3.1.180
MetaCyc2.3.1.180
Rhea expert-curated reactions2.3.1.180
UniProtKB/Swiss-Prot
Q81JG0, FABH1_BACANQ81GM0, FABH1_BACCRO34746, FABH1_BACSU
Q8ABI8, FABH1_BACTNP49244, FABH1_CUPWRQ9RT23, FABH1_DEIRA
Q9K8W9, FABH1_HALH5Q88YZ4, FABH1_LACPLQ8CPT4, FABH1_STAES
Q82BB8, FABH1_STRAWP72392, FABH1_STRCOQ9KQH5, FABH1_VIBCH
Q87N20, FABH1_VIBPAQ8D8G6, FABH1_VIBVUQ7M7J9, FABH1_VIBVY
Q81JF6, FABH2_BACANQ81F42, FABH2_BACCRO07600, FABH2_BACSU
Q8A137, FABH2_BACTNP49245, FABH2_CUPWRQ9RT22, FABH2_DEIRA
Q9KET5, FABH2_HALH5Q88WG8, FABH2_LACPLQ8CUB8, FABH2_STAES
Q82M29, FABH2_STRAWQ9Z4Y5, FABH2_STRCOQ9KLJ3, FABH2_VIBCH
Q87HJ2, FABH2_VIBPAQ8D719, FABH2_VIBVUQ7M7I3, FABH2_VIBVY
O54151, FABH3_STRCOQ9ZBV4, FABH4_STRCOQ9JN82, FABH5_STRCO
Q9PMZ6, FABHL_CAMJEB0CE67, FABH_ACAM1A9NFF0, FABH_ACHLI
A5FV65, FABH_ACICJB9MDQ9, FABH_ACIETA1WAX8, FABH_ACISJ
A3N232, FABH_ACTP2A6VQV2, FABH_ACTSZQ8UG62, FABH_AGRFC
Q21XP4, FABH_ALBFTA8ERJ6, FABH_ALIB4Q5E409, FABH_ALIF1
Q0A8R5, FABH_ALKEHB9JV87, FABH_ALLAMQ5PA98, FABH_ANAMM
O67185, FABH_AQUAEP49243, FABH_ARATHQ5P0D6, FABH_AROAE
B6YS41, FABH_AZOPCA1K5Y5, FABH_AZOSBA8FBX4, FABH_BACP2
A1USI9, FABH_BARBKQ6G3K4, FABH_BARHEQ6G000, FABH_BARQU
A9IVB4, FABH_BART1Q1LT37, FABH_BAUCHQ7VR18, FABH_BLOFL
Q492Q4, FABH_BLOPBQ2KUK5, FABH_BORA1Q7WD20, FABH_BORBR
Q7W5I4, FABH_BORPAA9IIH4, FABH_BORPDQ7VW29, FABH_BORPE
Q89K89, FABH_BRADUA5EKG5, FABH_BRASBA4YW84, FABH_BRASO
B2S524, FABH_BRUA1Q2YNB9, FABH_BRUA2A6X1X8, FABH_BRUA4
Q57DX4, FABH_BRUABA9MAF6, FABH_BRUC2C0RIB3, FABH_BRUMB
Q8YGH9, FABH_BRUMEA5VPV8, FABH_BRUO2B0CLA2, FABH_BRUSI
Q8G1E0, FABH_BRUSUA0K5U6, FABH_BURCHQ39I86, FABH_BURL3
A3MM55, FABH_BURM7A2S9Y2, FABH_BURM9Q62LU2, FABH_BURMA
A1V6D0, FABH_BURMSB1JYA0, FABH_BURO0Q1BXV4, FABH_BURO1
A3NXM9, FABH_BURP0Q3JQ65, FABH_BURP1A3NBU2, FABH_BURP6
Q63S83, FABH_BURPSQ2SXU7, FABH_BURTAA4JCP8, FABH_BURVG
Q8R9V7, FABH_CALS4A4XJW0, FABH_CALS8A7ZC01, FABH_CAMC1
A7H054, FABH_CAMC5A0RMK8, FABH_CAMFFA7I3D6, FABH_CAMHC
A8FKB7, FABH_CAMJ8A7H541, FABH_CAMJDQ9PIH1, FABH_CAMJE
A1VY47, FABH_CAMJJQ5HWE3, FABH_CAMJRQ9A8I4, FABH_CAUVC
A3PJ64, FABH_CERS1Q3J365, FABH_CERS4A4WTT9, FABH_CERS5
Q11J83, FABH_CHESBQ3AQ09, FABH_CHLCHQ820E6, FABH_CHLCV
Q3B6K8, FABH_CHLL3Q9PKF5, FABH_CHLMUA1BJA1, FABH_CHLPD
A4SCL4, FABH_CHLPMQ9Z8P0, FABH_CHLPNQ3KMC3, FABH_CHLTA
Q8KAP2, FABH_CHLTEO84242, FABH_CHLTRQ7NSK7, FABH_CHRVO
A8AHY1, FABH_CITK8Q97DA2, FABH_CLOABA7FPM6, FABH_CLOB1
C3KWF7, FABH_CLOB6A6LSC2, FABH_CLOB8A5I7X8, FABH_CLOBH
C1FNK7, FABH_CLOBJB1IHN1, FABH_CLOBKA7GJJ9, FABH_CLOBL
B1KU74, FABH_CLOBMQ18B40, FABH_CLOD6B9DY04, FABH_CLOK1
A5N4E1, FABH_CLOK5A0PXB6, FABH_CLONNQ0TRH0, FABH_CLOP1
Q8XLH3, FABH_CLOPEQ0STU9, FABH_CLOPSQ899P3, FABH_CLOTE
B6J8E5, FABH_COXB1B6J1I6, FABH_COXB2A9KEA1, FABH_COXBN
A9NBY3, FABH_COXBRQ820X0, FABH_COXBUA7MFQ4, FABH_CROS8
Q0K8L9, FABH_CUPNHQ46Z05, FABH_CUPPJB3R213, FABH_CUPTR
P0DW99, FABH_CUTACC1D0N4, FABH_DEIDVQ1J198, FABH_DEIGD
A9BNK6, FABH_DELASB8FRS6, FABH_DESHDQ24U40, FABH_DESHY
Q6AJF8, FABH_DESPSA5EXD7, FABH_DICNVA8LLT4, FABH_DINSH
A7ZKJ4, FABH_ECO24P0A6R2, FABH_ECO57A7ZZ48, FABH_ECOHS
A1A9Y5, FABH_ECOK1Q0TIY3, FABH_ECOL5P0A6R1, FABH_ECOL6
B1IUH4, FABH_ECOLCP0A6R0, FABH_ECOLIQ1RD66, FABH_ECOUT
Q3YRP7, FABH_EHRCJQ2GH17, FABH_EHRCRQ5FFP2, FABH_EHRRG
Q5HAV9, FABH_EHRRWA4W9A5, FABH_ENT38Q820T1, FABH_ENTFA
Q2N925, FABH_ERYLHQ8RGX7, FABH_FUSNNQ5L1U1, FABH_GEOKA
Q7NF35, FABH_GLOVIQ0BTE0, FABH_GRABCQ6B945, FABH_GRATL
Q7U337, FABH_HAEDUQ4QP30, FABH_HAEI8A5UFW1, FABH_HAEIG
P43711, FABH_HAEINQ17YQ2, FABH_HELAHP59813, FABH_HELHP
B6JKD5, FABH_HELP2B5Z9X2, FABH_HELPGQ1CUV9, FABH_HELPH
Q9ZMN0, FABH_HELPJB2US32, FABH_HELPSO24994, FABH_HELPY
A4G6T2, FABH_HERARQ0I0V6, FABH_HISS1B0UUZ0, FABH_HISS2
Q0C312, FABH_HYPNAA6SXP9, FABH_JANMAQ28RG1, FABH_JANSC
A6T7F1, FABH_KLEP7B2GFZ7, FABH_KOCRDQ1IQ32, FABH_KORVE
Q1GAG1, FABH_LACDAQ04AU8, FABH_LACDBA8YXS0, FABH_LACH4
Q9CHG0, FABH_LACLAA2RM32, FABH_LACLMQ030J8, FABH_LACLS
C1DCE8, FABH_LARHHQ38XG4, FABH_LATSSQ03RV2, FABH_LEVBA
A5VK78, FABH_LIMRDB2G7L1, FABH_LIMRJQ929H1, FABH_LISIN
C0LNR0, FABH_LISM4Q71XG3, FABH_LISMFQ8Y573, FABH_LISMO
A0AKV5, FABH_LISW6A1U0E3, FABH_MARN8Q606L3, FABH_METCA
B0JXE2, FABH_MICANB1MKD7, FABH_MYCA9B2A2M5, FABH_NATTJ
Q5F4X5, FABH_NEIG1B4RJI1, FABH_NEIG2A9M142, FABH_NEIM0
Q9JW56, FABH_NEIMAQ9JXR6, FABH_NEIMBA1KRY9, FABH_NEIMF
Q2GDD8, FABH_NEOSMQ0AIS4, FABH_NITECQ82U60, FABH_NITEU
Q2YA46, FABH_NITMUQ72CS6, FABH_NITV2A1VEK1, FABH_NITV4
B8DJG1, FABH_NITV9Q8Z062, FABH_NOSS1Q2G5S1, FABH_NOVAD
Q8ERU6, FABH_OCEIHQ04DM7, FABH_OENOBQ30YM1, FABH_OLEA2
A1TLD7, FABH_PARC0A6LEP7, FABH_PARD8A1B364, FABH_PARDP
Q2W4R7, FABH_PARM1B2JFI9, FABH_PARP8Q9CJS8, FABH_PASMU
Q6D690, FABH_PECASC0QPF4, FABH_PERMHQ7N384, FABH_PHOLL
A6KXK3, FABH_PHOV8A4SVV4, FABH_POLAQA1VRU7, FABH_POLNA
B1XTK6, FABH_POLNSQ126I8, FABH_POLSJB2RH63, FABH_PORG3
Q7MAV3, FABH_PORGIP51196, FABH_PORPUP31176, FABH_PORUM
A3PAK3, FABH_PROM0A8G2E1, FABH_PROM2A2BUB2, FABH_PROM5
Q31D45, FABH_PROM9Q7VE55, FABH_PROMAQ7V4F6, FABH_PROMM
Q7V3E0, FABH_PROMPQ46HN8, FABH_PROMTQ15TZ6, FABH_PSEA6
B7V4R0, FABH_PSEA8Q02QG7, FABH_PSEABQ9HYR2, FABH_PSEAE
Q3IBW0, FABH_PSET1A1STW1, FABH_PSYINQ1XDU1, FABH_PYRYE
Q8Y0J4, FABH_RALN1B2U968, FABH_RALPJQ1MIS6, FABH_RHIJ3
Q982Z8, FABH_RHILOQ92QT4, FABH_RHIMEB9JCY9, FABH_RHIR8
A5VC86, FABH_RHIWRP59814, FABH_RHOBAP30790, FABH_RHOCA
B6IMR5, FABH_RHOCSQ2RTS8, FABH_RHORTA8GPW1, FABH_RICAH
A8GY06, FABH_RICB8Q1RKA5, FABH_RICBRA8EZX3, FABH_RICCK
Q92GC1, FABH_RICCNQ4UK49, FABH_RICFEA8F2R3, FABH_RICM5
Q9ZCH1, FABH_RICPRB0BV80, FABH_RICROA8GTP2, FABH_RICRS
Q68VX7, FABH_RICTYA7NK75, FABH_ROSCSQ164C9, FABH_ROSDO
A5UWI7, FABH_ROSS1Q1AW87, FABH_RUBXDQ5LQJ5, FABH_RUEPO
Q1GI69, FABH_RUESTA9MGC9, FABH_SALARQ57QG4, FABH_SALCH
Q5PGU1, FABH_SALPAA9N5L3, FABH_SALPBQ8Z7J6, FABH_SALTI
O85139, FABH_SALTYA8GD17, FABH_SERP5Q8EDH1, FABH_SHEON
Q31ZE6, FABH_SHIBSQ32EV1, FABH_SHIDSQ0T5U5, FABH_SHIF8
Q83RS8, FABH_SHIFLQ3Z326, FABH_SHISSA6U7Q5, FABH_SINMW
Q2NU42, FABH_SODGMQ01QV9, FABH_SOLUEQ1GT90, FABH_SPHAL
Q07510, FABH_SPIOLA7X0K2, FABH_STAA1A6U089, FABH_STAA2
Q2FI93, FABH_STAA3Q2FZS0, FABH_STAA8A5IRG0, FABH_STAA9
Q2YWV3, FABH_STAABQ5HHA2, FABH_STAACA6QFJ3, FABH_STAAE
P68795, FABH_STAAMP99159, FABH_STAANQ6GIA4, FABH_STAAR
Q6GAU3, FABH_STAASA8Z088, FABH_STAATQ8NXE2, FABH_STAAW
Q5HQI2, FABH_STAEQQ4L4Z3, FABH_STAHJQ49WB6, FABH_STAS1
Q3K338, FABH_STRA1P64112, FABH_STRA3P64113, FABH_STRA5
C0M7U3, FABH_STRE4B4U1B3, FABH_STREMQ54206, FABH_STRGA
A8AYW5, FABH_STRGCQ9F6D4, FABH_STRLIQ8DSN2, FABH_STRMU
Q99YD2, FABH_STRP1Q04M58, FABH_STRP2P0DB00, FABH_STRP3
B5E7F8, FABH_STRP4Q5XAE0, FABH_STRP6C1C5F4, FABH_STRP7
P64115, FABH_STRP8Q1JA87, FABH_STRPBQ1JKE0, FABH_STRPC
Q1JFD2, FABH_STRPDQ1J582, FABH_STRPFA2RCX0, FABH_STRPG
B1I9L1, FABH_STRPIB8ZLI3, FABH_STRPJQ48RR7, FABH_STRPM
P0A3C5, FABH_STRPNP0DB01, FABH_STRPQB2ILW2, FABH_STRPS
B5XHY5, FABH_STRPZP0A3C6, FABH_STRR6A4W3N0, FABH_STRS2
C0ME18, FABH_STRS7A3CQ60, FABH_STRSVA4VXD4, FABH_STRSY
Q5M184, FABH_STRT1Q5M5S1, FABH_STRT2Q03M55, FABH_STRTD
B9DVE9, FABH_STRU0C1CCI2, FABH_STRZJC1CIR8, FABH_STRZP
C1CPS7, FABH_STRZTQ30PN6, FABH_SULDNA6QBY0, FABH_SULNB
Q67PG0, FABH_SYMTHQ31N84, FABH_SYNE7Q5N5X5, FABH_SYNP6
A5GP11, FABH_SYNPWA5GQJ2, FABH_SYNR3Q0AVV3, FABH_SYNWW
P73951, FABH_SYNY3Q8DKL4, FABH_THEVBQ3SIM4, FABH_THIDA
B8GSX7, FABH_THISHQ114K0, FABH_TRIEIQ3M9J4, FABH_TRIV2
P64117, FABH_TROW8P64116, FABH_TROWTC5CSE2, FABH_VARPS
A1WMX5, FABH_VEREIA5CWU7, FABH_VESOHQ73GG9, FABH_WOLPM
B3CML1, FABH_WOLPPQ5GS22, FABH_WOLTRQ8PNE8, FABH_XANAC
Q4URQ0, FABH_XANC8Q8PBV1, FABH_XANCPQ3BWI9, FABH_XANE5
Q2P7B9, FABH_XANOMQ9PCG4, FABH_XYLFAQ87CL7, FABH_XYLFT
A1JN67, FABH_YERE8A7FH25, FABH_YERP3Q1C6M8, FABH_YERPA
Q8ZFT7, FABH_YERPEQ1CI19, FABH_YERPNA4TLS3, FABH_YERPP
Q669L1, FABH_YERPSQ9HU15, FABY_PSEAE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-