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ENZYME

ENZYME entry: EC 2.3.1.309

Accepted Name
[beta-tubulin]-L-lysine N-acetyltransferase
Reaction catalysed
acetyl-CoA + L-lysyl-[beta-tubulin] = CoA + H(+) + N(6)-acetyl-L-lysyl-[beta-tubulin]
Comment(s)
  • The enzyme acetylates L-lysine at position 252 of beta-tubulin, which is located at the interface of alpha/beta-tubulin heterodimers and interacts with the phosphate group of the alpha-tubulin-bound GTP.
  • The acetylation is thought to attenuate tubulin incorporation into microtubules.
  • The enzyme catalyzing this activity (NAA50) also catalyzes the acetylation of certain N-terminal methionyl residues. That activity is classified as EC 2.3.1.258. cf. EC 2.3.1.108.
Cross-references
BRENDA2.3.1.309
EC2PDB2.3.1.309
ExplorEnz2.3.1.309
PRIAM enzyme-specific profiles2.3.1.309
KEGG Ligand Database for Enzyme Nomenclature2.3.1.309
IUBMB Enzyme Nomenclature2.3.1.309
IntEnz2.3.1.309
MEDLINEFind literature relating to 2.3.1.309
MetaCyc2.3.1.309
Rhea expert-curated reactions2.3.1.309

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-