Home  |  Contact

ENZYME entry: EC

Accepted Name
cholate--CoA ligase.
Alternative Name(s)
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP- forming).
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate--CoA ligase.
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase.
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase.
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase.
bile acid CoA ligase.
bile acid coenzyme A ligase.
cholate thiokinase.
cholic acid:CoA ligase.
cholic thiokinase.
choloyl-CoA synthetase.
choloyl coenzyme A synthetase.
cholyl-CoA synthetase.
THCA-CoA ligase.
trihydroxycoprostanoyl-CoA synthetase.
Reaction catalysed
  • ATP + cholate + CoA <=> AMP + choloyl-CoA + diphosphate
  • (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA <=> (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate
  • This membrane-bound enzyme catalyzes the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters.
  • The second step involves EC and converts the acyl-CoA thioester into the corresponding N-acyl amidate by conjugation with glycine or taurine.
  • Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates.
  • Formerly EC
PRIAM enzyme-specific profiles6.2.1.7
KEGG Ligand Database for Enzyme Nomenclature6.2.1.7
IUBMB Enzyme Nomenclature6.2.1.7
MEDLINEFind literature relating to
Rhea expert-curated reactions6.2.1.7
P19409, BAIB_CLOSV;  O14975, S27A2_HUMAN;  O35488, S27A2_MOUSE;  
P97524, S27A2_RAT;  Q9Y2P5, S27A5_HUMAN;  Q4LDG0, S27A5_MOUSE;  
Q9ES38, S27A5_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-