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ENZYME entry: EC 2.3.1.86

Accepted Name
Fatty-acyl-CoA synthase system.
Alternative Name(s)
Fatty-acyl-CoA synthase.
Yeast fatty acid synthase.
Reaction catalysed
Acetyl-CoA + n malonyl-CoA + 2n NADPH <=> long-chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+)
Comment(s)
  • The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi- functional protein complex composed of two subunits.
  • One subunit catalyzes the reactions EC 1.1.1.100 and EC 2.3.1.41, while the other subunit catalyzes the reactions of EC 2.3.1.38, EC 2.3.1.39, EC 4.2.1.59, EC 1.3.1.10 and EC 1.1.1.279.
  • The enzyme differs from the animal enzyme (EC 2.3.1.85) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
Cross-references
BRENDA2.3.1.86
EC2PDB2.3.1.86
ExplorEnz2.3.1.86
PRIAM enzyme-specific profiles2.3.1.86
KEGG Ligand Database for Enzyme Nomenclature2.3.1.86
IUBMB Enzyme Nomenclature2.3.1.86
IntEnz2.3.1.86
MEDLINEFind literature relating to 2.3.1.86
MetaCyc2.3.1.86
Rhea expert-curated reactions2.3.1.86
UniProtKB/Swiss-Prot
Q8TGA2, AFLA_ASPPU;  Q8TGA1, AFLB_ASPPU;  Q5AV00, ATNF_EMENI;  
Q5AV07, ATNM_EMENI;  P34731, FAS1_CANAX;  Q9UUG0, FAS1_SCHPO;  
P34229, FAS1_YARLI;  P07149, FAS1_YEAST;  P43098, FAS2_CANAX;  
G8BAW7, FAS2_CANPC;  P78615, FAS2_EMEND;  Q765N2, FAS2_LACKL;  
P15368, FAS2_PENPA;  Q10289, FAS2_SCHPO;  P19097, FAS2_YEAST;  
I1S489, GRA7_GIBZE;  I1R9A6, GRA9_GIBZE;  A7TUG9, HEXA_DOTSE;  
M2YJJ3, HEXA_DOTSN;  M2XHU6, HEXB_DOTSN;  Q2TXF0, ORYA_ASPOR;  
Q2TXG3, ORYB_ASPOR;  Q5B7V0, PKIB_EMENI;  A0A1U8QK63, PKIC_EMENI;  

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