ENZYME entry: EC 2.3.1.86
Accepted Name |
fatty-acyl-CoA synthase system.
|
Alternative Name(s) |
fatty-acyl-CoA synthase. |
yeast fatty acid synthase. |
Reaction catalysed |
acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH <=> a long-chain fatty acyl-CoA + n CO2 + n CoA + H2O + 2n NADP(+) |
Comment(s) |
- The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-
functional protein complex composed of two subunits.
- One subunit catalyzes the reactions EC 1.1.1.100 and EC 2.3.1.41,
while the other subunit catalyzes the reactions of EC 2.3.1.38,
EC 2.3.1.39, EC 4.2.1.59, EC 1.3.1.10 and EC 1.1.1.279.
- The enzyme differs from the animal enzyme (EC 2.3.1.85) in that the
enoyl reductase domain requires FMN as a cofactor, and the ultimate
product is an acyl-CoA (usually palmitoyl-CoA) instead of a free
fatty acid.
|
Cross-references |
BRENDA | 2.3.1.86 |
EC2PDB | 2.3.1.86 |
ExplorEnz | 2.3.1.86 |
PRIAM enzyme-specific profiles | 2.3.1.86 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.86 |
IUBMB Enzyme Nomenclature | 2.3.1.86 |
IntEnz | 2.3.1.86 |
MEDLINE | Find literature relating to 2.3.1.86 |
MetaCyc | 2.3.1.86 |
Rhea expert-curated reactions | 2.3.1.86 |
UniProtKB/Swiss-Prot |
Q8TGA2, AFLA_ASPPU; | Q8TGA1, AFLB_ASPPU; | Q5AV00, ATNF_EMENI; |
Q5AV07, ATNM_EMENI; | P34731, FAS1_CANAX; | Q9UUG0, FAS1_SCHPO; |
P34229, FAS1_YARLI; | P07149, FAS1_YEAST; | P43098, FAS2_CANAX; |
G8BAW7, FAS2_CANPC; | P78615, FAS2_EMEND; | Q765N2, FAS2_LACKL; |
P15368, FAS2_PENPA; | Q10289, FAS2_SCHPO; | P19097, FAS2_YEAST; |
I1S489, GRA7_GIBZE; | I1R9A6, GRA9_GIBZE; | A7TUG9, HEXA_DOTSE; |
M2YJJ3, HEXA_DOTSN; | M2XHU6, HEXB_DOTSN; | Q2TXF0, ORYA_ASPOR; |
Q2TXG3, ORYB_ASPOR; | Q5B7V0, PKIB_EMENI; | A0A1U8QK63, PKIC_EMENI; |
Q00681, STCJ_EMENI; | Q00706, STCK_EMENI; |
|
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