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ENZYME

ENZYME entry: EC 2.3.1.86

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.86
Accepted Name
fatty-acyl-CoA synthase system
Alternative Name(s)
fatty-acyl-CoA synthase
yeast fatty acid synthase
Reaction catalysed
acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+)
Comment(s)
  • The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi- functional protein complex composed of two subunits.
  • One subunit catalyzes the reactions EC 1.1.1.100 and EC 2.3.1.41, while the other subunit catalyzes the reactions of EC 2.3.1.38, EC 2.3.1.39, EC 4.2.1.59, EC 1.3.1.10 and EC 1.1.1.279.
  • The enzyme differs from the animal enzyme (EC 2.3.1.85) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
Cross-references
BRENDA2.3.1.86
EC2PDB2.3.1.86
ExplorEnz2.3.1.86
KEGG Ligand Database for Enzyme Nomenclature2.3.1.86
IUBMB Enzyme Nomenclature2.3.1.86
MEDLINEFind literature relating to 2.3.1.86
MetaCyc2.3.1.86
Rhea expert-curated reactions2.3.1.86
UniProtKB/Swiss-Prot
Q8TGA2, AFLA_ASPPUQ8TGA1, AFLB_ASPPUQ5AV00, ATNF_EMENI
Q5AV07, ATNM_EMENIP34731, FAS1_CANAXQ9UUG0, FAS1_SCHPO
P34229, FAS1_YARLIP07149, FAS1_YEASTP43098, FAS2_CANAX
G8BAW7, FAS2_CANPCP78615, FAS2_EMENDQ765N2, FAS2_LACKL
P15368, FAS2_PENPAQ10289, FAS2_SCHPOP19097, FAS2_YEAST
I1S489, GRA7_GIBZEI1R9A6, GRA9_GIBZEA7TUG9, HEXA_DOTSE
M2YJJ3, HEXA_DOTSNM2XHU6, HEXB_DOTSNQ2TXF0, ORYA_ASPOR
Q2TXG3, ORYB_ASPORA0A1D5AG16, PIGJ_MONRUA0A1C8AX29, PIGK_MONRU
Q5B7V0, PKIB_EMENIA0A1U8QK63, PKIC_EMENIQ00681, STCJ_EMENI
Q00706, STCK_EMENIQ92215, TOXC_COCCAS5NIA2, TOXH_COCCA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-