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ENZYME entry: EC 2.3.2.33

Accepted Name
RCR-type E3 ubiquitin transferase.
Alternative Name(s)
MYCBP2.
PHR1.
Reaction catalysed
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-threonine <=> [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-3-O-ubiquitinyl-L-threonine
Comment(s)
  • RCR-type E3 ubiquitin transferases is a class of RING-type E3 ubiquitin transferase (see EC 2.3.2.27) that mediates ubiquitination of acceptor proteins via an internal cysteine residue.
  • The RING1 domain binds an EC 2.3.2.23 and transfers the ubiquitin that is bound to it to an internal cysteine residue on a mediator loop of the RCR-type ligase.
  • The ubiquitin may be transferred to a second internal cysteine before the transfer of the ubiquitin from the RCR-type ligase to the substrate.
Cross-references
BRENDA2.3.2.33
EC2PDB2.3.2.33
ExplorEnz2.3.2.33
PRIAM enzyme-specific profiles2.3.2.33
KEGG Ligand Database for Enzyme Nomenclature2.3.2.33
IUBMB Enzyme Nomenclature2.3.2.33
IntEnz2.3.2.33
MEDLINEFind literature relating to 2.3.2.33
MetaCyc2.3.2.33
Rhea expert-curated reactions2.3.2.33
UniProtKB/Swiss-Prot
Q9NB71, HIW_DROME;  F1RD40, MYCB2_DANRE;  O75592, MYCB2_HUMAN;  
Q7TPH6, MYCB2_MOUSE;  Q17551, RPM1_CAEEL;  

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