Home  |  Contact

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.1.144

Accepted Name
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase.
Alternative Name(s)
Beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase.
GlcNAc-T III.
GnTIII.
N-acetylglucosaminyltransferase III.
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III.
Uridine diphosphoacetylglucosamine-glycopeptide beta-4- acetylglucosaminyltransferase III.
Reaction catalysed
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-(beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] <=> UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-(beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6))-(beta-D-GlcNAc-(1->4))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
Comment(s)
  • The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus.
  • The residue added by the enzyme at position 4 of the beta-linked mannose of the trimannosyl core of N-glycans is known as a bisecting GlcNAc.
  • Unlike GlcNAc residues added to other positions, it is not extended or modified.
  • In addition, its presence prevents the action of other branching enzymes involved in the process such as GlcNAc-T IV (EC 2.4.1.145) and GlcNAc-T V (EC 2.4.1.155), and thus increased activity of GlcNAc- T III leads to a decrease in highly branched N-glycan structures.
  • Formerly EC 2.4.1.51.
Cross-references
BRENDA2.4.1.144
EC2PDB2.4.1.144
ExplorEnz2.4.1.144
PRIAM enzyme-specific profiles2.4.1.144
KEGG Ligand Database for Enzyme Nomenclature2.4.1.144
IUBMB Enzyme Nomenclature2.4.1.144
IntEnz2.4.1.144
MEDLINEFind literature relating to 2.4.1.144
MetaCyc2.4.1.144
UniProtKB/Swiss-Prot
Q09327, MGAT3_HUMAN;  Q10470, MGAT3_MOUSE;  Q02527, MGAT3_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-