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ENZYME

ENZYME entry: EC 2.4.1.144

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.144
Accepted Name
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Alternative Name(s)
beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
GlcNAc-T III
GnTIII
N-acetylglucosaminyltransferase III
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
uridine diphosphoacetylglucosamine-glycopeptide beta4- acetylglucosaminyltransferase III
Reaction catalysed
N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)
Comment(s)
  • The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus.
  • The residue added by the enzyme at position 4 of the beta-linked mannose of the trimannosyl core of N-glycans is known as a bisecting GlcNAc.
  • Unlike GlcNAc residues added to other positions, it is not extended or modified.
  • In addition, its presence prevents the action of other branching enzymes involved in the process such as GlcNAc-T IV (EC 2.4.1.145) and GlcNAc-T V (EC 2.4.1.155), and thus increased activity of GlcNAc- T III leads to a decrease in highly branched N-glycan structures.
  • Formerly EC 2.4.1.51.
Cross-references
BRENDA2.4.1.144
EC2PDB2.4.1.144
ExplorEnz2.4.1.144
KEGG Ligand Database for Enzyme Nomenclature2.4.1.144
IUBMB Enzyme Nomenclature2.4.1.144
MEDLINEFind literature relating to 2.4.1.144
MetaCyc2.4.1.144
Rhea expert-curated reactions2.4.1.144
UniProtKB/Swiss-Prot
Q09327, MGAT3_HUMANQ10470, MGAT3_MOUSEQ02527, MGAT3_RAT

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