Accepted Name |
protein O-GlcNAc transferase
|
Alternative Name(s) |
OGTase |
O-linked N-acetylglucosaminyltransferase |
Reaction catalysed |
- L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)
- L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)
|
Comment(s) |
- Within higher eukaryotes post-translational modification of protein
serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic,
inducible and abundant, regulating many cellular processes by
interfering with protein phosphorylation.
- EC 2.4.1.255 transfers GlcNAc onto substrate proteins and
EC 3.2.1.169 cleaves GlcNAc from the modified proteins.
|
Cross-references |
BRENDA | 2.4.1.255 |
EC2PDB | 2.4.1.255 |
ExplorEnz | 2.4.1.255 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.255 |
IUBMB Enzyme Nomenclature | 2.4.1.255 |
MEDLINE | Find literature relating to 2.4.1.255 |
MetaCyc | 2.4.1.255 |
Rhea expert-curated reactions | 2.4.1.255 |
UniProtKB/Swiss-Prot |
A0JND3, EOGT_BOVIN | Q5NDL9, EOGT_CANLF | Q5NDL3, EOGT_CHICK |
Q9VQB7, EOGT_DROME | Q5NDL2, EOGT_HUMAN | Q8BYW9, EOGT_MOUSE |
Q5NDL1, EOGT_PANTR | Q5NDL0, EOGT_RAT | Q6GQ23, EOGT_XENLA |
Q08CY9, EOGT_XENTR | O18158, OGT1_CAEEL | A8BFN4, OGT1_GIAIC |
O15294, OGT1_HUMAN | Q8CGY8, OGT1_MOUSE | Q27HV0, OGT1_PIG |
P81436, OGT1_RABIT | P56558, OGT1_RAT | Q9M8Y0, SEC_ARATH |
Q96301, SPY_ARATH | Q8LP10, SPY_EUSER | O82422, SPY_HORVU |
Q6YZI0, SPY_ORYSJ | O82039, SPY_PETHY | Q8RVB2, SPY_SOLLC |
|
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