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ENZYME entry: EC 2.4.1.255

Accepted Name
Protein O-GlcNAc transferase.
Alternative Name(s)
O-linked N-acetylglucosaminyltransferase.
OGTase.
Reaction catalysed
  • UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine <=> UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
  • UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine <=> UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine
Comment(s)
  • Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation.
  • EC 2.4.1.255 transfers GlcNAc onto substrate proteins and EC 3.2.1.169 cleaves GlcNAc from the modified proteins.
Cross-references
BRENDA2.4.1.255
EC2PDB2.4.1.255
ExplorEnz2.4.1.255
PRIAM enzyme-specific profiles2.4.1.255
KEGG Ligand Database for Enzyme Nomenclature2.4.1.255
IUBMB Enzyme Nomenclature2.4.1.255
IntEnz2.4.1.255
MEDLINEFind literature relating to 2.4.1.255
MetaCyc2.4.1.255
Rhea expert-curated reactions2.4.1.255
UniProtKB/Swiss-Prot
A0JND3, EOGT_BOVIN;  Q5NDL9, EOGT_CANLF;  Q5NDL3, EOGT_CHICK;  
Q9VQB7, EOGT_DROME;  Q5NDL2, EOGT_HUMAN;  Q8BYW9, EOGT_MOUSE;  
Q5NDL1, EOGT_PANTR;  Q5NDL0, EOGT_RAT;  Q6GQ23, EOGT_XENLA;  
Q08CY9, EOGT_XENTR;  O18158, OGT1_CAEEL;  A8BFN4, OGT1_GIAIC;  
O15294, OGT1_HUMAN;  Q8CGY8, OGT1_MOUSE;  Q27HV0, OGT1_PIG;  
P81436, OGT1_RABIT;  P56558, OGT1_RAT;  Q9M8Y0, SEC_ARATH;  
Q96301, SPY_ARATH;  Q8LP10, SPY_EUSER;  O82422, SPY_HORVU;  
Q6YZI0, SPY_ORYSJ;  O82039, SPY_PETHY;  Q8RVB2, SPY_SOLLC;  

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