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ENZYME

ENZYME entry: EC 2.4.1.255

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.255
Accepted Name
protein O-GlcNAc transferase
Alternative Name(s)
OGTase
O-linked N-acetylglucosaminyltransferase
Reaction catalysed
  • L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)
  • L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)
Comment(s)
  • Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation.
  • EC 2.4.1.255 transfers GlcNAc onto substrate proteins and EC 3.2.1.169 cleaves GlcNAc from the modified proteins.
Cross-references
BRENDA2.4.1.255
EC2PDB2.4.1.255
ExplorEnz2.4.1.255
KEGG Ligand Database for Enzyme Nomenclature2.4.1.255
IUBMB Enzyme Nomenclature2.4.1.255
MEDLINEFind literature relating to 2.4.1.255
MetaCyc2.4.1.255
Rhea expert-curated reactions2.4.1.255
UniProtKB/Swiss-Prot
A0JND3, EOGT_BOVINQ5NDL9, EOGT_CANLFQ5NDL3, EOGT_CHICK
Q9VQB7, EOGT_DROMEQ5NDL2, EOGT_HUMANQ8BYW9, EOGT_MOUSE
Q5NDL1, EOGT_PANTRQ5NDL0, EOGT_RATQ6GQ23, EOGT_XENLA
Q08CY9, EOGT_XENTRO18158, OGT1_CAEELA8BFN4, OGT1_GIAIC
O15294, OGT1_HUMANQ8CGY8, OGT1_MOUSEQ27HV0, OGT1_PIG
P81436, OGT1_RABITP56558, OGT1_RATQ9M8Y0, SEC_ARATH
Q96301, SPY_ARATHQ8LP10, SPY_EUSRUO82422, SPY_HORVU
Q6YZI0, SPY_ORYSJO82039, SPY_PETHYQ8RVB2, SPY_SOLLC

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-