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ENZYME entry: EC 3.2.1.169

Accepted Name
protein O-GlcNAcase.
Alternative Name(s)
glycoside hydrolase O-GlcNAcase.
OGA.
O-GlcNAcase.
O-GlcNAc hydrolase.
Reaction catalysed
  • 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O <=> L-seryl-[protein] + N-acetyl-D-glucosamine
  • 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O <=> L-threonyl-[protein] + N-acetyl-D-glucosamine
Comment(s)
  • Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation.
  • EC 2.4.1.155 transfers GlcNAc onto substrate proteins and EC 3.2.1.169 cleaves GlcNAc from the modified proteins.
Cross-references
BRENDA3.2.1.169
EC2PDB3.2.1.169
ExplorEnz3.2.1.169
PRIAM enzyme-specific profiles3.2.1.169
KEGG Ligand Database for Enzyme Nomenclature3.2.1.169
IUBMB Enzyme Nomenclature3.2.1.169
IntEnz3.2.1.169
MEDLINEFind literature relating to 3.2.1.169
MetaCyc3.2.1.169
Rhea expert-curated reactions3.2.1.169
UniProtKB/Swiss-Prot
Q89ZI2, OGA_BACTN;  Q0TR53, OGA_CLOP1;  Q8XL08, OGA_CLOPE;  
O60502, OGA_HUMAN;  Q9EQQ9, OGA_MOUSE;  Q2CEE3, OGA_OCEGH;  
Q8VIJ5, OGA_RAT;  

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