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ENZYME entry: EC 2.4.1.376

Accepted Name
EGF-domain serine glucosyltransferase.
Reaction catalysed
L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP
Comment(s)
  • The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains.
  • Glycosylation takes place at the serine in the C-X-S-X-P-C motif.
  • The enzyme is bifunctional also being active with UDP-alpha-xylose as donor (EC 2.4.2.63).
  • When present on Notch proteins, the trisaccharide functions as a modulator of the signaling activity of this protein.
Cross-references
BRENDA2.4.1.376
EC2PDB2.4.1.376
ExplorEnz2.4.1.376
PRIAM enzyme-specific profiles2.4.1.376
KEGG Ligand Database for Enzyme Nomenclature2.4.1.376
IUBMB Enzyme Nomenclature2.4.1.376
IntEnz2.4.1.376
MEDLINEFind literature relating to 2.4.1.376
MetaCyc2.4.1.376
Rhea expert-curated reactions2.4.1.376
UniProtKB/Swiss-Prot
Q5E9Q1, PGLT1_BOVIN;  Q8NBL1, PGLT1_HUMAN;  Q8BYB9, PGLT1_MOUSE;  
G3V9D0, PGLT1_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
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