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ENZYME entry: EC

Accepted Name
EGF-domain serine glucosyltransferase.
Reaction catalysed
L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose <=> 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP
  • The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains.
  • Glycosylation takes place at the serine in the C-X-S-X-P-C motif.
  • The enzyme is bifunctional also being active with UDP-alpha-xylose as donor (EC
  • When present on Notch proteins, the trisaccharide functions as a modulator of the signaling activity of this protein.
PRIAM enzyme-specific profiles2.4.1.376
KEGG Ligand Database for Enzyme Nomenclature2.4.1.376
IUBMB Enzyme Nomenclature2.4.1.376
MEDLINEFind literature relating to
Rhea expert-curated reactions2.4.1.376
G3V9D0, PGLT1_RAT;  

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