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ENZYME entry: EC 4.6.1.1

Accepted Name
Adenylate cyclase.
Alternative Name(s)
3',5'-cyclic AMP synthetase.
Adenyl cyclase.
Adenylyl cyclase.
ATP pyrophosphate-lyase.
Reaction catalysed
ATP <=> 3',5'-cyclic AMP + diphosphate
Comment(s)
  • Also acts on dATP to form 3',5'-cyclic dAMP.
  • Requires pyruvate.
  • Activated by NAD(+) in presence of EC 2.4.2.31.
Cross-references
PROSITEPDOC00425 ; PDOC00837
BRENDA4.6.1.1
EC2PDB4.6.1.1
ExplorEnz4.6.1.1
PRIAM enzyme-specific profiles4.6.1.1
KEGG Ligand Database for Enzyme Nomenclature4.6.1.1
IUBMB Enzyme Nomenclature4.6.1.1
IntEnz4.6.1.1
MEDLINEFind literature relating to 4.6.1.1
MetaCyc4.6.1.1
UniProtKB/Swiss-Prot
Q9VP76, AC78C_DROME;  P83855, ACLP_MOUSE;  Q9VK50, ACXE_DROME;  
P19754, ADCY1_BOVIN;  Q08828, ADCY1_HUMAN;  O88444, ADCY1_MOUSE;  
Q9VW60, ADCY2_DROME;  Q08462, ADCY2_HUMAN;  Q80TL1, ADCY2_MOUSE;  
P26769, ADCY2_RAT;  O60266, ADCY3_HUMAN;  Q8VHH7, ADCY3_MOUSE;  
P21932, ADCY3_RAT;  Q8NFM4, ADCY4_HUMAN;  Q91WF3, ADCY4_MOUSE;  
P26770, ADCY4_RAT;  P30803, ADCY5_CANLF;  O95622, ADCY5_HUMAN;  
P84309, ADCY5_MOUSE;  P40144, ADCY5_RABIT;  Q04400, ADCY5_RAT;  
P30804, ADCY6_CANLF;  O43306, ADCY6_HUMAN;  Q01341, ADCY6_MOUSE;  
Q03343, ADCY6_RAT;  Q29450, ADCY7_BOVIN;  P51828, ADCY7_HUMAN;  
P51829, ADCY7_MOUSE;  P40145, ADCY8_HUMAN;  P97490, ADCY8_MOUSE;  
P40146, ADCY8_RAT;  Q9DGG6, ADCY9_CHICK;  O60503, ADCY9_HUMAN;  
P51830, ADCY9_MOUSE;  P98999, ADCY9_XENLA;  Q96PN6, ADCYA_HUMAN;  
Q8C0T9, ADCYA_MOUSE;  Q866F4, ADCYA_RABIT;  Q9Z286, ADCYA_RAT;  
Q99279, CY41_TRYBB;  Q99396, CY42_TRYBB;  Q99280, CY43_TRYBB;  
P32870, CYA1_DROME;  P0A4Y1, CYA1_MYCBO;  P9WQ34, CYA1_MYCTO;  
P9WQ35, CYA1_MYCTU;  P19485, CYA1_RHIME;  Q52915, CYA2_RHIME;  
Q9Z3Q0, CYA3_RHIME;  Q26721, CYA4_TRYBB;  Q59119, CYAA_AERHY;  
P43524, CYAA_ANACY;  P40136, CYAA_BACAN;  Q57506, CYAA_BORBR;  
J7QLC0, CYAA_BORP1;  P0DKX7, CYAA_BORPE;  P40130, CYAA_DICCH;  
Q03100, CYAA_DICDI;  Q8XAP1, CYAA_ECO57;  Q8FBP0, CYAA_ECOL6;  
P00936, CYAA_ECOLI;  P27580, CYAA_GLUNI;  P40134, CYAA_HAEIN;  
P23466, CYAA_LACKL;  Q27675, CYAA_LEIDO;  Q01631, CYAA_NEUCR;  
Q05766, CYAA_PASMU;  Q01513, CYAA_PODAS;  Q59685, CYAA_PROMI;  
P0A1A8, CYAA_SALTI;  P0A1A7, CYAA_SALTY;  P14605, CYAA_SCHPO;  
P59739, CYAA_SHIFL;  P40137, CYAA_STIAU;  P40135, CYAA_STRCO;  
Q9WXC3, CYAA_STRGR;  Q26896, CYAA_TRYCO;  P26338, CYAA_TRYEQ;  
P49606, CYAA_USTMA;  P08678, CYAA_YEAST;  P30528, CYAA_YERIN;  
P40127, CYAA_YERPE;  O69199, CYAB_AERHY;  Q25263, CYAB_LEIDO;  
P40138, CYAB_STIAU;  Q55F68, CYAD_DICDI;  Q03101, CYAG_DICDI;  
Q8S9F2, PCYAA_EUGGR;  Q76L34, PCYAA_EUGLO;  Q8S9F1, PCYAB_EUGGR;  
Q76L33, PCYAB_EUGLO;  P9WMU8, Y1264_MYCTO;  P9WMU9, Y1264_MYCTU;  
Q57692, Y240_METJA;  

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