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ENZYME

ENZYME entry: EC 4.6.1.1

PURL: https://purl.expasy.org/enzyme/EC/4.6.1.1
Accepted Name
adenylate cyclase
Alternative Name(s)
3',5'-cyclic AMP synthetase
adenyl cyclase
adenylyl cyclase
ATP pyrophosphate-lyase
Reaction catalysed
ATP = 3',5'-cyclic AMP + diphosphate
Comment(s)
  • Also acts on dATP to form 3',5'-cyclic dAMP.
  • Requires pyruvate.
  • Activated by NAD(+) in presence of EC 2.4.2.31.
Cross-references
BRENDA4.6.1.1
EC2PDB4.6.1.1
ExplorEnz4.6.1.1
KEGG Ligand Database for Enzyme Nomenclature4.6.1.1
IUBMB Enzyme Nomenclature4.6.1.1
MEDLINEFind literature relating to 4.6.1.1
MetaCyc4.6.1.1
Rhea expert-curated reactions4.6.1.1
UniProtKB/Swiss-Prot
Q9VP76, AC78C_DROMEP83855, ACLP_MOUSEQ9VK50, ACXE_DROME
P19754, ADCY1_BOVINQ08828, ADCY1_HUMANO88444, ADCY1_MOUSE
Q9VW60, ADCY2_DROMEQ08462, ADCY2_HUMANQ80TL1, ADCY2_MOUSE
P26769, ADCY2_RATO60266, ADCY3_HUMANQ8VHH7, ADCY3_MOUSE
P21932, ADCY3_RATQ8NFM4, ADCY4_HUMANQ91WF3, ADCY4_MOUSE
P26770, ADCY4_RATP30803, ADCY5_CANLFO95622, ADCY5_HUMAN
P84309, ADCY5_MOUSEP40144, ADCY5_RABITQ04400, ADCY5_RAT
P30804, ADCY6_CANLFO43306, ADCY6_HUMANQ01341, ADCY6_MOUSE
Q03343, ADCY6_RATQ29450, ADCY7_BOVINP51828, ADCY7_HUMAN
P51829, ADCY7_MOUSEP40145, ADCY8_HUMANP97490, ADCY8_MOUSE
P40146, ADCY8_RATQ9DGG6, ADCY9_CHICKO60503, ADCY9_HUMAN
P51830, ADCY9_MOUSEP98999, ADCY9_XENLAQ96PN6, ADCYA_HUMAN
Q8C0T9, ADCYA_MOUSEQ866F4, ADCYA_RABITQ9Z286, ADCYA_RAT
Q99279, CY41_TRYBBQ99396, CY42_TRYBBQ99280, CY43_TRYBB
P32870, CYA1_DROMEP0A4Y1, CYA1_MYCBOP9WQ34, CYA1_MYCTO
P9WQ35, CYA1_MYCTUP19485, CYA1_RHIMEQ52915, CYA2_RHIME
Q9Z3Q0, CYA3_RHIMEQ26721, CYA4_TRYBBQ59119, CYAA_AERHY
P43524, CYAA_ANACYP40136, CYAA_BACANQ57506, CYAA_BORBR
J7QLC0, CYAA_BORP1P0DKX7, CYAA_BORPEP40130, CYAA_DICCH
Q03100, CYAA_DICDIQ8XAP1, CYAA_ECO57Q8FBP0, CYAA_ECOL6
P00936, CYAA_ECOLIP27580, CYAA_GLUNIP40134, CYAA_HAEIN
P23466, CYAA_LACKLQ27675, CYAA_LEIDOP49606, CYAA_MYCMD
Q01631, CYAA_NEUCRQ05766, CYAA_PASMUQ01513, CYAA_PODAS
Q59685, CYAA_PROMIP0A1A8, CYAA_SALTIP0A1A7, CYAA_SALTY
P14605, CYAA_SCHPOP59739, CYAA_SHIFLP40137, CYAA_STIAU
P40135, CYAA_STRCOQ9WXC3, CYAA_STRGRQ26896, CYAA_TRYCO
P26338, CYAA_TRYEQP08678, CYAA_YEASTP30528, CYAA_YERIN
P40127, CYAA_YERPEO69199, CYAB_AERHYQ25263, CYAB_LEIDO
P40138, CYAB_STIAUQ55F68, CYAD_DICDIQ03101, CYAG_DICDI
O07732, LIPJ_MYCTUQ8S9F2, PCYAA_EUGGRQ76L34, PCYAA_EUGLO
Q8S9F1, PCYAB_EUGGRQ76L33, PCYAB_EUGLOP9WMU8, Y1264_MYCTO
P9WMU9, Y1264_MYCTUQ57692, Y240_METJA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-