A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 4.6.1.1

Accepted Name
Adenylate cyclase.
Alternative Name(s)
3',5'-cyclic AMP synthetase.
Adenyl cyclase.
Adenylyl cyclase.
ATP pyrophosphate-lyase.
Reaction catalysed
ATP <=> 3',5'-cyclic AMP + diphosphate
Comment(s)
  • Also acts on dATP to form 3',5'-cyclic dAMP.
  • Requires pyruvate.
  • Activated by NAD(+) in presence of EC 2.4.2.31.
Cross-references
PROSITEPDOC00425 ; PDOC00837
BRENDA4.6.1.1
EC2PDB4.6.1.1
ExplorEnz4.6.1.1
PRIAM enzyme-specific profiles4.6.1.1
KEGG Ligand Database for Enzyme Nomenclature4.6.1.1
IUBMB Enzyme Nomenclature4.6.1.1
IntEnz4.6.1.1
MEDLINEFind literature relating to 4.6.1.1
MetaCyc4.6.1.1
UniProtKB/Swiss-Prot
P83855, ACLP_MOUSE;  Q9VK50, ACXE_DROME;  P19754, ADCY1_BOVIN;  
Q08828, ADCY1_HUMAN;  O88444, ADCY1_MOUSE;  Q9VW60, ADCY2_DROME;  
Q08462, ADCY2_HUMAN;  Q80TL1, ADCY2_MOUSE;  P26769, ADCY2_RAT;  
O60266, ADCY3_HUMAN;  Q8VHH7, ADCY3_MOUSE;  P21932, ADCY3_RAT;  
Q8NFM4, ADCY4_HUMAN;  Q91WF3, ADCY4_MOUSE;  P26770, ADCY4_RAT;  
P30803, ADCY5_CANLF;  O95622, ADCY5_HUMAN;  P84309, ADCY5_MOUSE;  
P40144, ADCY5_RABIT;  Q04400, ADCY5_RAT;  P30804, ADCY6_CANLF;  
O43306, ADCY6_HUMAN;  Q01341, ADCY6_MOUSE;  Q03343, ADCY6_RAT;  
Q29450, ADCY7_BOVIN;  P51828, ADCY7_HUMAN;  P51829, ADCY7_MOUSE;  
P40145, ADCY8_HUMAN;  P97490, ADCY8_MOUSE;  P40146, ADCY8_RAT;  
Q9DGG6, ADCY9_CHICK;  O60503, ADCY9_HUMAN;  P51830, ADCY9_MOUSE;  
P98999, ADCY9_XENLA;  Q96PN6, ADCYA_HUMAN;  Q8C0T9, ADCYA_MOUSE;  
Q866F4, ADCYA_RABIT;  Q9Z286, ADCYA_RAT;  Q99279, CY41_TRYBB;  
Q99396, CY42_TRYBB;  Q99280, CY43_TRYBB;  P32870, CYA1_DROME;  
P0A4Y1, CYA1_MYCBO;  P9WQ34, CYA1_MYCTO;  P9WQ35, CYA1_MYCTU;  
P19485, CYA1_RHIME;  Q52915, CYA2_RHIME;  Q9Z3Q0, CYA3_RHIME;  
Q26721, CYA4_TRYBB;  Q59119, CYAA_AERHY;  P43524, CYAA_ANACY;  
P40136, CYAA_BACAN;  Q57506, CYAA_BORBR;  J7QLC0, CYAA_BORP1;  
P0DKX7, CYAA_BORPE;  P40130, CYAA_DICCH;  Q03100, CYAA_DICDI;  
Q8XAP1, CYAA_ECO57;  Q8FBP0, CYAA_ECOL6;  P00936, CYAA_ECOLI;  
P27580, CYAA_GLUNI;  P40134, CYAA_HAEIN;  P23466, CYAA_LACKL;  
Q27675, CYAA_LEIDO;  Q01631, CYAA_NEUCR;  Q05766, CYAA_PASMU;  
Q01513, CYAA_PODAS;  Q59685, CYAA_PROMI;  P0A1A8, CYAA_SALTI;  
P0A1A7, CYAA_SALTY;  P14605, CYAA_SCHPO;  P59739, CYAA_SHIFL;  
P40137, CYAA_STIAU;  P40135, CYAA_STRCO;  Q9WXC3, CYAA_STRGR;  
Q26896, CYAA_TRYCO;  P26338, CYAA_TRYEQ;  P49606, CYAA_USTMA;  
P08678, CYAA_YEAST;  P30528, CYAA_YERIN;  P40127, CYAA_YERPE;  
O69199, CYAB_AERHY;  Q25263, CYAB_LEIDO;  P40138, CYAB_STIAU;  
Q55F68, CYAD_DICDI;  Q03101, CYAG_DICDI;  Q8S9F2, PCYAA_EUGGR;  
Q76L34, PCYAA_EUGLO;  Q8S9F1, PCYAB_EUGGR;  Q76L33, PCYAB_EUGLO;  
P9WMU8, Y1264_MYCTO;  P9WMU9, Y1264_MYCTU;  Q57692, Y240_METJA;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.6.1.-
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