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ENZYME entry: EC 2.7.7.66

Accepted Name
malonate decarboxylase holo-[acyl-carrier protein] synthase.
Alternative Name(s)
holo ACP synthase.
holo-malonate-decarboxylase synthase.
Reaction catalysed
2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[malonate decarboxylase ACP] <=> diphosphate + holo-[malonate decarboxylase ACP]
Comment(s)
  • The delta subunit of malonate decarboxylase serves as an an acyl- carrier protein (ACP) and contains the prosthetic group 2'-(5-triphosphoribosyl)-3'-dephospho-CoA.
  • Two reactions are involved in the production of the holo-ACP form of this enzyme.
  • The first reaction is catalyzed by EC 2.4.2.52.
  • The resulting prosthetic group is then attached to the ACP subunit via a phosphodiester linkage to a serine residue, thus forming the holo form of the enzyme, in a manner analogous to that of EC 2.7.7.61.
Cross-references
BRENDA2.7.7.66
EC2PDB2.7.7.66
ExplorEnz2.7.7.66
PRIAM enzyme-specific profiles2.7.7.66
KEGG Ligand Database for Enzyme Nomenclature2.7.7.66
IUBMB Enzyme Nomenclature2.7.7.66
IntEnz2.7.7.66
MEDLINEFind literature relating to 2.7.7.66
MetaCyc2.7.7.66
Rhea expert-curated reactions2.7.7.66
UniProtKB/Swiss-Prot
C1DNP9, MDCG_AZOVD;  Q89XP2, MDCG_BRADU;  B5XRA3, MDCG_KLEP3;  
A6T8R9, MDCG_KLEP7;  P71426, MDCG_KLEPN;  Q9I6S5, MDCG_PSEAE;  
Q4K4G0, MDCG_PSEF5;  Q3K5C0, MDCG_PSEPF;  B0KQS7, MDCG_PSEPG;  
Q9Z448, MDCG_PSEPU;  B1J9E4, MDCG_PSEPW;  Q87V59, MDCG_PSESM;  
Q8PPW9, MDCG_XANAC;  Q3BY34, MDCG_XANC5;  Q4UZ66, MDCG_XANC8;  
B0RN93, MDCG_XANCB;  Q8P4U3, MDCG_XANCP;  

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