ENZYME entry: EC 2.4.99.21
Accepted Name |
Dolichyl-phosphooligosaccharide-protein glycotransferase.
|
Alternative Name(s) |
Archaeal oligosaccharyl transferase. |
Dolichyl-monophosphooligosaccharide-protein glycotransferase. |
Reaction catalysed |
An archaeal dolichyl phosphooligosaccharide + [protein]-L-asparagine <=> an archaeal dolichyl phosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine |
Cofactor(s) |
Mn(2+).
|
Comment(s) |
- The enzyme, characterized from the archaea Methanococcus voltae and
Haloferax volcanii, transfers a glycan component from dolichyl
phosphooligosaccharide to external proteins.
- It is different from EC 2.4.99.18 which uses dolichyl diphosphate as
carrier compound in bacteria and eukaryotes.
- The enzyme participates in the N-glycosylation of proteins in some
archaea.
- Dolichol used by archaea is different from that used by eukaryotes;
it is much shorter (C(55)-C(60)), it is alpha,omega-saturated and it
may have additional unsaturated positions in the chain.
|
Cross-references |
BRENDA | 2.4.99.21 |
EC2PDB | 2.4.99.21 |
ExplorEnz | 2.4.99.21 |
PRIAM enzyme-specific profiles | 2.4.99.21 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.99.21 |
IUBMB Enzyme Nomenclature | 2.4.99.21 |
IntEnz | 2.4.99.21 |
MEDLINE | Find literature relating to 2.4.99.21 |
MetaCyc | 2.4.99.21 |
Rhea expert-curated reactions | 2.4.99.21 |
UniProtKB/Swiss-Prot |
O29918, AGLB1_ARCFU; | Q8U4D2, AGLB1_PYRFU; | O74088, AGLB1_PYRHO; |
O30195, AGLB2_ARCFU; | Q8U3P6, AGLB2_PYRFU; | O58981, AGLB2_PYRHO; |
O29867, AGLB3_ARCFU; | D4GYH4, AGLB_HALVD; | Q58920, AGLB_METJA; |
Q2EMT4, AGLB_METVO; |
|
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