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ENZYME entry: EC 2.4.99.21
| Accepted Name |
|---|
| Dolichyl-phosphooligosaccharide-protein glycotransferase.
|
| Alternative Name(s) |
|---|
| Archaeal oligosaccharyl transferase. |
| Dolichyl-monophosphooligosaccharide-protein glycotransferase. |
| Reaction catalysed |
|---|
| An archaeal dolichyl phosphooligosaccharide + [protein]-L-asparagine <=> an archaeal dolichyl phosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine |
| Cofactor(s) |
|---|
| Mn(2+).
|
| Comment(s) |
|---|
- The enzyme, characterized from the archaea Methanococcus voltae and
Haloferax volcanii, transfers a glycan component from dolichyl
phosphooligosaccharide to external proteins.
- It is different from EC 2.4.99.18 which uses dolichyl diphosphate as
carrier compound in bacteria and eukaryotes.
- The enzyme participates in the N-glycosylation of proteins in some
archaea.
- Dolichol used by archaea is different from that used by eukaryotes;
it is much shorter (C(55)-C(60)), it is alpha,omega-saturated and it
may have additional unsaturated positions in the chain.
|
| Cross-references |
|---|
| BRENDA | 2.4.99.21 |
| EC2PDB | 2.4.99.21 |
| ExplorEnz | 2.4.99.21 |
| PRIAM enzyme-specific profiles | 2.4.99.21 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.99.21 |
| IUBMB Enzyme Nomenclature | 2.4.99.21 |
| IntEnz | 2.4.99.21 |
| MEDLINE | Find literature relating to 2.4.99.21 |
| MetaCyc | 2.4.99.21 |
| UniProtKB/Swiss-Prot |
| O29918, AGLB1_ARCFU; | Q8U4D2, AGLB1_PYRFU; | O74088, AGLB1_PYRHO; |
| O30195, AGLB2_ARCFU; | Q8U3P6, AGLB2_PYRFU; | O58981, AGLB2_PYRHO; |
| O29867, AGLB3_ARCFU; | D4GYH4, AGLB_HALVD; | Q58920, AGLB_METJA; |
| Q2EMT4, AGLB_METVO; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-