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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.99.21

Accepted Name
Dolichyl-phosphooligosaccharide-protein glycotransferase.
Alternative Name(s)
Archaeal oligosaccharyl transferase.
Dolichyl-monophosphooligosaccharide-protein glycotransferase.
Reaction catalysed
An archaeal dolichyl phosphooligosaccharide + [protein]-L-asparagine <=> an archaeal dolichyl phosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine
Cofactor(s)
Mn(2+).
Comment(s)
  • The enzyme, characterized from the archaea Methanococcus voltae and Haloferax volcanii, transfers a glycan component from dolichyl phosphooligosaccharide to external proteins.
  • It is different from EC 2.4.99.18 which uses dolichyl diphosphate as carrier compound in bacteria and eukaryotes.
  • The enzyme participates in the N-glycosylation of proteins in some archaea.
  • Dolichol used by archaea is different from that used by eukaryotes; it is much shorter (C(55)-C(60)), it is alpha,omega-saturated and it may have additional unsaturated positions in the chain.
Cross-references
BRENDA2.4.99.21
EC2PDB2.4.99.21
ExplorEnz2.4.99.21
PRIAM enzyme-specific profiles2.4.99.21
KEGG Ligand Database for Enzyme Nomenclature2.4.99.21
IUBMB Enzyme Nomenclature2.4.99.21
IntEnz2.4.99.21
MEDLINEFind literature relating to 2.4.99.21
MetaCyc2.4.99.21
UniProtKB/Swiss-Prot
O29918, AGLB1_ARCFU;  Q8U4D2, AGLB1_PYRFU;  O74088, AGLB1_PYRHO;  
O30195, AGLB2_ARCFU;  Q8U3P6, AGLB2_PYRFU;  O58981, AGLB2_PYRHO;  
O29867, AGLB3_ARCFU;  D4GYH4, AGLB_HALVD;  Q58920, AGLB_METJA;  
Q2EMT4, AGLB_METVO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
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