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ENZYME entry: EC 2.5.1.118

Accepted Name
beta-(isoxazolin-5-on-2-yl)-L-alanine synthase.
Reaction catalysed
isoxazolin-5-one + O-acetyl-L-serine <=> 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)
Comment(s)
  • The enzyme from the plants Lathyrus odoratus (sweet pea) and L.sativus (grass pea) also forms 3-(5-oxoisoxazolin-4-yl)-L-alanine in vitro (cf. EC 2.5.1.119).
  • However, only 3-(5-oxoisoxazolin-2-yl)-L-alanine is formed in vivo.
  • 3-(5-oxoisoxazolin-2-yl)-L-alanine is the biosynthetic precursor of the neurotoxin N(3)-oxalyl-L-2,3-diaminopropanoic acid, the cause of lathyrism.
  • Closely related and possibly identical to EC 2.5.1.47 and EC 2.5.1.51.
Cross-references
BRENDA2.5.1.118
EC2PDB2.5.1.118
ExplorEnz2.5.1.118
PRIAM enzyme-specific profiles2.5.1.118
KEGG Ligand Database for Enzyme Nomenclature2.5.1.118
IUBMB Enzyme Nomenclature2.5.1.118
IntEnz2.5.1.118
MEDLINEFind literature relating to 2.5.1.118
MetaCyc2.5.1.118
Rhea expert-curated reactions2.5.1.118

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-