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ENZYME entry: EC 2.5.1.132

Accepted Name
3-deoxy-D-glycero-D-galacto-nononate 9-phosphate synthase.
Alternative Name(s)
2-keto-3-deoxy-D-glycero-D-galacto-9-phosphonononic acid synthase.
KDN 9-P synthase.
Reaction catalysed
Phosphoenolpyruvate + D-mannose 6-phosphate + H(2)O <=> 3-deoxy-D-glycero-D-galacto-nononate 9-phosphate + phosphate
Comment(s)
  • The enzyme participates in the biosynthesis of the sialic acid 3-deoxy-D-glycero-D-galacto-nononate (KDN).
  • The human sialic acid synthase (EC 2.5.1.57) is also able to catalyze the reaction.
  • KDN is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
Cross-references
BRENDA2.5.1.132
EC2PDB2.5.1.132
ExplorEnz2.5.1.132
PRIAM enzyme-specific profiles2.5.1.132
KEGG Ligand Database for Enzyme Nomenclature2.5.1.132
IUBMB Enzyme Nomenclature2.5.1.132
IntEnz2.5.1.132
MEDLINEFind literature relating to 2.5.1.132
MetaCyc2.5.1.132

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-