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ENZYME

ENZYME entry: EC 2.5.1.15

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.15
Accepted Name
dihydropteroate synthase
Alternative Name(s)
DHPS
dihydropteroate diphosphorylase
dihydropteroate pyrophosphorylase
Reaction catalysed
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate
Comment(s)
  • The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea).
  • The enzyme exists in varying types of multifunctional proteins in different organisms.
  • The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC 2.7.6.3, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC 4.1.2.25.
Cross-references
BRENDA2.5.1.15
EC2PDB2.5.1.15
ExplorEnz2.5.1.15
KEGG Ligand Database for Enzyme Nomenclature2.5.1.15
IUBMB Enzyme Nomenclature2.5.1.15
MEDLINEFind literature relating to 2.5.1.15
MetaCyc2.5.1.15
Rhea expert-curated reactions2.5.1.15
UniProtKB/Swiss-Prot
P0C004, DHP1_CORGTP0C002, DHP1_ECOLXQ49184, DHP1_MYCFO
P0C003, DHP1_PSEAIP0AC11, DHP2_ECOLXP0AC12, DHP2_SHIFL
C0HMD9, DHP3_ECOLXO25830, DHPRS_HELPYP0A579, DHPS1_MYCBO
P0C0X1, DHPS1_MYCLEP9WND0, DHPS1_MYCTOP9WND1, DHPS1_MYCTU
P28822, DHPS_BACSUQ05621, DHPS_CLOB8P0AC14, DHPS_ECOL6
P0AC13, DHPS_ECOLIP43776, DHPS_HAEINQ9JT70, DHPS_NEIMA
Q51161, DHPS_NEIMBP57696, DHPS_NEIMCP0AC15, DHPS_SHIFL
Q5HIG1, DHPS_STAACP64141, DHPS_STAAMP64142, DHPS_STAAN
Q6GJF7, DHPS_STAARQ6GBX4, DHPS_STAASO05701, DHPS_STAAU
Q8NXZ2, DHPS_STAAWQ5HRP0, DHPS_STAEQQ8CMT7, DHPS_STAES
Q59919, DHPS_STAHAP0C0G1, DHPS_STRP1P0DB08, DHPS_STRP3
Q5XCA8, DHPS_STRP6Q8P152, DHPS_STRP8P05382, DHPS_STRPN
P0DB09, DHPS_STRPQP0C0G0, DHPS_STRPYP59655, DHPS_STRR6
P73248, DHPS_SYNY3Q54YD9, FOL1_DICDIP29251, FOL1_PNECA
Q4LB35, FOL1_SCHPOP53848, FOL1_YEASTQ9HS44, FOLCP_HALSA
D4GW05, FOLCP_HALVDQ1ENB6, FOLC_ARATHQ821E2, FOLKP_CHLCV
P82602, FOLKP_CHLMUQ9Z7E8, FOLKP_CHLPNO84619, FOLKP_CHLTR
Q9SZV3, FOLM_ARATHO04862, FOLM_PEA

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-