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ENZYME

ENZYME entry: EC 2.5.1.15

Accepted Name
dihydropteroate synthase
Alternative Name(s)
DHPS
dihydropteroate diphosphorylase
dihydropteroate pyrophosphorylase
Reaction catalysed
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate
Comment(s)
  • The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants and fungi) and methanopterin (in archaea).
  • The enzyme exists in varying types of multifunctional proteins in different organisms.
  • The enzyme from the plant Arabidopsis thaliana also harbors the activity of EC 2.7.6.3, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with the two above mentioned activities as well as EC 4.1.2.25.
Cross-references
BRENDA2.5.1.15
EC2PDB2.5.1.15
ExplorEnz2.5.1.15
PRIAM enzyme-specific profiles2.5.1.15
KEGG Ligand Database for Enzyme Nomenclature2.5.1.15
IUBMB Enzyme Nomenclature2.5.1.15
IntEnz2.5.1.15
MEDLINEFind literature relating to 2.5.1.15
MetaCyc2.5.1.15
Rhea expert-curated reactions2.5.1.15
UniProtKB/Swiss-Prot
P0C004, DHP1_CORGTP0C002, DHP1_ECOLXQ49184, DHP1_MYCFO
P0C003, DHP1_PSEAIP0AC11, DHP2_ECOLXP0AC12, DHP2_SHIFL
O25830, DHPRS_HELPYP0A579, DHPS1_MYCBOP0C0X1, DHPS1_MYCLE
P9WND0, DHPS1_MYCTOP9WND1, DHPS1_MYCTUP28822, DHPS_BACSU
Q05621, DHPS_CLOB8P0AC14, DHPS_ECOL6P0AC13, DHPS_ECOLI
P43776, DHPS_HAEINQ9JT70, DHPS_NEIMAQ51161, DHPS_NEIMB
P57696, DHPS_NEIMCP0AC15, DHPS_SHIFLQ5HIG1, DHPS_STAAC
P64141, DHPS_STAAMP64142, DHPS_STAANQ6GJF7, DHPS_STAAR
Q6GBX4, DHPS_STAASO05701, DHPS_STAAUQ8NXZ2, DHPS_STAAW
Q5HRP0, DHPS_STAEQQ8CMT7, DHPS_STAESQ59919, DHPS_STAHA
P0C0G1, DHPS_STRP1P0DB08, DHPS_STRP3Q5XCA8, DHPS_STRP6
Q8P152, DHPS_STRP8P05382, DHPS_STRPNP0DB09, DHPS_STRPQ
P0C0G0, DHPS_STRPYP59655, DHPS_STRR6P73248, DHPS_SYNY3
Q54YD9, FOL1_DICDIP29251, FOL1_PNECAQ4LB35, FOL1_SCHPO
P53848, FOL1_YEASTQ9HS44, FOLCP_HALSAD4GW05, FOLCP_HALVD
Q1ENB6, FOLC_ARATHQ821E2, FOLKP_CHLCVP82602, FOLKP_CHLMU
Q9Z7E8, FOLKP_CHLPNO84619, FOLKP_CHLTRQ9SZV3, FOLM_ARATH
O04862, FOLM_PEA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-