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ENZYME

ENZYME entry: EC 2.7.6.3

Accepted Name
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
Alternative Name(s)
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
6-hydroxymethyl-7,8-dihydropterin diphosphokinase
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
7,8-dihydro-6-hydroxymethylpterin diphosphokinase
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase
Reaction catalysed
6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)
Comment(s)
  • The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants, fungi, and some archaeal species, including the haloarchaea) and methanopterin (in some archaeal species such as the Archaeoglobi and Methanobacteria).
  • The enzyme exists in varying types of multifunctional proteins in different organisms.
  • The enzyme from the bacterium Streptococcus pneumoniae also harbors the activity of EC 4.1.2.25, the enzyme from the plant Arabidopsis thaliana harbors the activity of EC 2.5.1.15, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with both of the two above mentioned activities.
Cross-references
BRENDA2.7.6.3
EC2PDB2.7.6.3
ExplorEnz2.7.6.3
PRIAM enzyme-specific profiles2.7.6.3
KEGG Ligand Database for Enzyme Nomenclature2.7.6.3
IUBMB Enzyme Nomenclature2.7.6.3
IntEnz2.7.6.3
MEDLINEFind literature relating to 2.7.6.3
MetaCyc2.7.6.3
Rhea expert-curated reactions2.7.6.3
UniProtKB/Swiss-Prot
Q54YD9, FOL1_DICDIP29251, FOL1_PNECAQ4LB35, FOL1_SCHPO
P53848, FOL1_YEASTQ1ENB6, FOLC_ARATHQ9CGE3, FOLKE_LACLA
Q8GJP4, FOLKE_LACLMQ821E2, FOLKP_CHLCVP82602, FOLKP_CHLMU
Q9Z7E8, FOLKP_CHLPNO84619, FOLKP_CHLTRQ9SZV3, FOLM_ARATH
O04862, FOLM_PEAO66550, HPPK_AQUAEP29252, HPPK_BACSU
Q9PJ54, HPPK_CAMJEP26281, HPPK_ECOLIP43777, HPPK_HAEIN
Q9ZM35, HPPK_HELPJO25680, HPPK_HELPYP71512, HPPK_METEA
P64144, HPPK_MYCBOO69528, HPPK_MYCLEP9WNC6, HPPK_MYCTO
P9WNC7, HPPK_MYCTUB2RI92, HPPK_PORG3P0C936, HPPK_PORGI
Q9HV71, HPPK_PSEAEO87790, HPPK_PSEPUP0C0G3, HPPK_STRP1
P0DB10, HPPK_STRP3Q5XCA6, HPPK_STRP6Q8P151, HPPK_STRP8
P0DB11, HPPK_STRPQP0C0G2, HPPK_STRPYP72736, HPPK_SYNY3
Q59028, MPTE_METJAO27637, MPTE_METTHQ8U2A9, MPTE_PYRFU
P22291, SULD_STRPNP59657, SULD_STRR6

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.6.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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