| Accepted Name |
|---|
| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.
|
| Alternative Name(s) |
|---|
| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. |
| 6-hydroxymethyl-7,8-dihydropterin diphosphokinase. |
| 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. |
| 7,8-dihydro-6-hydroxymethylpterin diphosphokinase. |
| 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase. |
| Reaction catalysed |
|---|
| ATP + 6-hydroxymethyl-7,8-dihydropterin <=> AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate |
| Cofactor(s) |
|---|
| Mg(2+).
|
| Comment(s) |
|---|
- The enzyme participates in the biosynthetic pathways for folate (in
bacteria, plants, fungi, and some archaeal species, including the
haloarchaea) and methanopterin (in some archaeal species such as the
Archaeoglobi and Methanobacteria).
- The enzyme exists in varying types of multifunctional proteins in
different organisms.
- The enzyme from the bacterium Streptococcus pneumoniae also harbors
the activity of EC 4.1.2.25, the enzyme from the plant Arabidopsis
thaliana harbors the activity of EC 2.5.1.15, while the enzyme from
yeast Saccharomyces cerevisiae is trifunctional with both of the two
above mentioned activities.
|
| Cross-references |
|---|
| PROSITE | PDOC00631 |
| BRENDA | 2.7.6.3 |
| EC2PDB | 2.7.6.3 |
| ExplorEnz | 2.7.6.3 |
| PRIAM enzyme-specific profiles | 2.7.6.3 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.7.6.3 |
| IUBMB Enzyme Nomenclature | 2.7.6.3 |
| IntEnz | 2.7.6.3 |
| MEDLINE | Find literature relating to 2.7.6.3 |
| MetaCyc | 2.7.6.3 |
| Rhea expert-curated reactions | 2.7.6.3 |
| UniProtKB/Swiss-Prot |
| Q54YD9, FOL1_DICDI; | P29251, FOL1_PNECA; | Q4LB35, FOL1_SCHPO; |
| P53848, FOL1_YEAST; | Q1ENB6, FOLC_ARATH; | Q9CGE3, FOLKE_LACLA; |
| Q8GJP4, FOLKE_LACLM; | Q821E2, FOLKP_CHLCV; | P82602, FOLKP_CHLMU; |
| Q9Z7E8, FOLKP_CHLPN; | O84619, FOLKP_CHLTR; | Q9SZV3, FOLM_ARATH; |
| O04862, FOLM_PEA; | O66550, HPPK_AQUAE; | P29252, HPPK_BACSU; |
| Q9PJ54, HPPK_CAMJE; | P26281, HPPK_ECOLI; | P43777, HPPK_HAEIN; |
| Q9ZM35, HPPK_HELPJ; | O25680, HPPK_HELPY; | P71512, HPPK_METEA; |
| P64144, HPPK_MYCBO; | O69528, HPPK_MYCLE; | P9WNC6, HPPK_MYCTO; |
| P9WNC7, HPPK_MYCTU; | B2RI92, HPPK_PORG3; | P0C936, HPPK_PORGI; |
| Q9HV71, HPPK_PSEAE; | O87790, HPPK_PSEPU; | P0C0G3, HPPK_STRP1; |
| P0DB10, HPPK_STRP3; | Q5XCA6, HPPK_STRP6; | Q8P151, HPPK_STRP8; |
| P0DB11, HPPK_STRPQ; | P0C0G2, HPPK_STRPY; | P72736, HPPK_SYNY3; |
| Q59028, MPTE_METJA; | O27637, MPTE_METTH; | Q8U2A9, MPTE_PYRFU; |
| P22291, SULD_STRPN; | P59657, SULD_STRR6; |
|