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ENZYME entry: EC 2.7.6.3

Accepted Name
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.
Alternative Name(s)
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase.
6-hydroxymethyl-7,8-dihydropterin diphosphokinase.
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
7,8-dihydro-6-hydroxymethylpterin diphosphokinase.
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase.
Reaction catalysed
6-hydroxymethyl-7,8-dihydropterin + ATP <=> (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)
Comment(s)
  • The enzyme participates in the biosynthetic pathways for folate (in bacteria, plants, fungi, and some archaeal species, including the haloarchaea) and methanopterin (in some archaeal species such as the Archaeoglobi and Methanobacteria).
  • The enzyme exists in varying types of multifunctional proteins in different organisms.
  • The enzyme from the bacterium Streptococcus pneumoniae also harbors the activity of EC 4.1.2.25, the enzyme from the plant Arabidopsis thaliana harbors the activity of EC 2.5.1.15, while the enzyme from yeast Saccharomyces cerevisiae is trifunctional with both of the two above mentioned activities.
Cross-references
BRENDA2.7.6.3
EC2PDB2.7.6.3
ExplorEnz2.7.6.3
PRIAM enzyme-specific profiles2.7.6.3
KEGG Ligand Database for Enzyme Nomenclature2.7.6.3
IUBMB Enzyme Nomenclature2.7.6.3
IntEnz2.7.6.3
MEDLINEFind literature relating to 2.7.6.3
MetaCyc2.7.6.3
Rhea expert-curated reactions2.7.6.3
UniProtKB/Swiss-Prot
Q54YD9, FOL1_DICDI;  P29251, FOL1_PNECA;  Q4LB35, FOL1_SCHPO;  
P53848, FOL1_YEAST;  Q1ENB6, FOLC_ARATH;  Q9CGE3, FOLKE_LACLA;  
Q8GJP4, FOLKE_LACLM;  Q821E2, FOLKP_CHLCV;  P82602, FOLKP_CHLMU;  
Q9Z7E8, FOLKP_CHLPN;  O84619, FOLKP_CHLTR;  Q9SZV3, FOLM_ARATH;  
O04862, FOLM_PEA;  O66550, HPPK_AQUAE;  P29252, HPPK_BACSU;  
Q9PJ54, HPPK_CAMJE;  P26281, HPPK_ECOLI;  P43777, HPPK_HAEIN;  
Q9ZM35, HPPK_HELPJ;  O25680, HPPK_HELPY;  P71512, HPPK_METEA;  
P64144, HPPK_MYCBO;  O69528, HPPK_MYCLE;  P9WNC6, HPPK_MYCTO;  
P9WNC7, HPPK_MYCTU;  B2RI92, HPPK_PORG3;  P0C936, HPPK_PORGI;  
Q9HV71, HPPK_PSEAE;  O87790, HPPK_PSEPU;  P0C0G3, HPPK_STRP1;  
P0DB10, HPPK_STRP3;  Q5XCA6, HPPK_STRP6;  Q8P151, HPPK_STRP8;  
P0DB11, HPPK_STRPQ;  P0C0G2, HPPK_STRPY;  P72736, HPPK_SYNY3;  
Q59028, MPTE_METJA;  O27637, MPTE_METTH;  Q8U2A9, MPTE_PYRFU;  
P22291, SULD_STRPN;  P59657, SULD_STRR6;  

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