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ENZYME

ENZYME entry: EC 4.1.2.25

PURL: https://purl.expasy.org/enzyme/EC/4.1.2.25
Accepted Name
dihydroneopterin aldolase
Alternative Name(s)
2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8- dihydropteridine glycolaldehyde-lyase
7,8-dihydroneopterin aldolase
Reaction catalysed
7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
Comment(s)
  • The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis.
  • The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyze the epimerisation of the 2' hydroxy-group (EC 5.1.99.8).
  • The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyzes EC 5.1.99.8 and EC 1.13.11.81.
  • The enzyme from the yeast Saccharomyces cerevisiae also catalyzes the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3 and EC 2.5.1.15.
Cross-references
BRENDA4.1.2.25
EC2PDB4.1.2.25
ExplorEnz4.1.2.25
KEGG Ligand Database for Enzyme Nomenclature4.1.2.25
IUBMB Enzyme Nomenclature4.1.2.25
MEDLINEFind literature relating to 4.1.2.25
MetaCyc4.1.2.25
Rhea expert-curated reactions4.1.2.25
UniProtKB/Swiss-Prot
Q54YD9, FOL1_DICDIP29251, FOL1_PNECAQ4LB35, FOL1_SCHPO
P53848, FOL1_YEASTQ9SF23, FOLB1_ARATHQ9FM54, FOLB2_ARATH
Q6GKX5, FOLB3_ARATHP28823, FOLB_BACSUQ9PJC6, FOLB_CHLMU
Q9Z7E9, FOLB_CHLPNO84620, FOLB_CHLTRP0AC17, FOLB_ECOL6
P0AC16, FOLB_ECOLIP46362, FOLB_HAEINP71513, FOLB_METEA
P0A581, FOLB_MYCBOO69529, FOLB_MYCLEP9WNC4, FOLB_MYCTO
P9WNC5, FOLB_MYCTUP0AC18, FOLB_SHIFLQ5HIG0, FOLB_STAAC
P64145, FOLB_STAAMP64146, FOLB_STAANQ6GJF6, FOLB_STAAR
Q6GBX3, FOLB_STAASP56740, FOLB_STAAUP64147, FOLB_STAAW
Q5HRN9, FOLB_STAEQQ8CMT8, FOLB_STAESQ59920, FOLB_STAHA
Q9X8I0, FOLB_STRCOP0C0G5, FOLB_STRP1P0DB12, FOLB_STRP3
Q5XCA7, FOLB_STRP6P0A3E2, FOLB_STRP8P0DB13, FOLB_STRPQ
P0C0G4, FOLB_STRPYP74342, FOLB_SYNY3Q57851, MPTD_METJA
Q8TX89, MPTD_METKAQ6L2J9, MPTD_PICTOP22291, SULD_STRPN
P59657, SULD_STRR6

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
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