A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.1.2.25
| Accepted Name |
|---|
| Dihydroneopterin aldolase.
|
| Alternative Name(s) |
|---|
| 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-
dihydropteridine glycolaldehyde-lyase. |
| 7,8-dihydroneopterin aldolase. |
| Reaction catalysed |
|---|
| 7,8-dihydroneopterin <=> 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde |
| Comment(s) |
|---|
- The enzyme participates in folate (in bacteria, plants and fungi) and
methanopterin (in archaea) biosynthesis.
- The enzymes from the bacterium Escherichia coli and the plant
Arabidopsis thaliana also catalyze the epimerisation of the 2'
hydroxy-group (EC 5.1.99.8).
- The enzyme from the bacterium Mycobacterium tuberculosis is
trifunctional and also catalyzes EC 5.1.99.8 and EC 1.13.11.81.
- The enzyme from the yeast Saccharomyces cerevisiae also catalyzes the
two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3
and EC 2.5.1.15.
|
| Cross-references |
|---|
| BRENDA | 4.1.2.25 |
| EC2PDB | 4.1.2.25 |
| ExplorEnz | 4.1.2.25 |
| PRIAM enzyme-specific profiles | 4.1.2.25 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.1.2.25 |
| IUBMB Enzyme Nomenclature | 4.1.2.25 |
| IntEnz | 4.1.2.25 |
| MEDLINE | Find literature relating to 4.1.2.25 |
| MetaCyc | 4.1.2.25 |
| UniProtKB/Swiss-Prot |
| Q54YD9, FOL1_DICDI; | P29251, FOL1_PNECA; | Q4LB35, FOL1_SCHPO; |
| P53848, FOL1_YEAST; | Q9SF23, FOLB1_ARATH; | Q9FM54, FOLB2_ARATH; |
| Q6GKX5, FOLB3_ARATH; | P28823, FOLB_BACSU; | Q9PJC6, FOLB_CHLMU; |
| Q9Z7E9, FOLB_CHLPN; | O84620, FOLB_CHLTR; | P0AC17, FOLB_ECOL6; |
| P0AC16, FOLB_ECOLI; | P46362, FOLB_HAEIN; | P71513, FOLB_METEA; |
| P0A581, FOLB_MYCBO; | O69529, FOLB_MYCLE; | P9WNC4, FOLB_MYCTO; |
| P9WNC5, FOLB_MYCTU; | P0AC18, FOLB_SHIFL; | Q5HIG0, FOLB_STAAC; |
| P64145, FOLB_STAAM; | P64146, FOLB_STAAN; | Q6GJF6, FOLB_STAAR; |
| Q6GBX3, FOLB_STAAS; | P56740, FOLB_STAAU; | P64147, FOLB_STAAW; |
| Q5HRN9, FOLB_STAEQ; | Q8CMT8, FOLB_STAES; | Q59920, FOLB_STAHA; |
| Q9X8I0, FOLB_STRCO; | P0C0G5, FOLB_STRP1; | P0DB12, FOLB_STRP3; |
| Q5XCA7, FOLB_STRP6; | P0A3E2, FOLB_STRP8; | P0DB13, FOLB_STRPQ; |
| P0C0G4, FOLB_STRPY; | P74342, FOLB_SYNY3; | Q57851, MPTD_METJA; |
| Q8TX89, MPTD_METKA; | Q6L2J9, MPTD_PICTO; | P22291, SULD_STRPN; |
| P59657, SULD_STRR6; |
|
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