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ENZYME

ENZYME entry: EC 2.5.1.157

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.157
Accepted Name
rRNA small subunit aminocarboxypropyltransferase
Reaction catalysed
an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)
Comment(s)
  • The enzyme, found in all eukaryotes and some archaea, catalyzes the final step in production of the modified rRNA nucleotide N(1)-methyl- N(3)-[(3S)-aminocarboxypropyl]-pseudouridine (m(1)acp(3)psi).
  • This modified nucleotide is present in the small subunit of ribosomal RNA (18S in eukaryotes and 16S in archaea). cf. EC 2.5.1.114 and EC 2.5.1.108.
Cross-references
BRENDA2.5.1.157
EC2PDB2.5.1.157
ExplorEnz2.5.1.157
KEGG Ligand Database for Enzyme Nomenclature2.5.1.157
IUBMB Enzyme Nomenclature2.5.1.157
MEDLINEFind literature relating to 2.5.1.157
MetaCyc2.5.1.157
Rhea expert-curated reactions2.5.1.157
UniProtKB/Swiss-Prot
B0R700, TSR3_HALS3Q9HNJ6, TSR3_HALSAQ9UJK0, TSR3_HUMAN
Q8TMY6, TSR3_METACQ469W0, TSR3_METBFQ12ZL9, TSR3_METBU
Q58118, TSR3_METJAQ8TXM4, TSR3_METKAQ8PSK5, TSR3_METMA
A5UJF3, TSR3_METS3Q2NET3, TSR3_METSTO26654, TSR3_METTH
Q5HZH2, TSR3_MOUSEC3NGU0, TSR3_SACI1C3MQM6, TSR3_SACI2
C3N6E6, TSR3_SACI3C3MWA4, TSR3_SACI4C4KHW1, TSR3_SACI6
C3NEV4, TSR3_SACI7Q9UWV6, TSR3_SACS2Q10409, TSR3_SCHPO
Q975W6, TSR3_SULTOQ9HM46, TSR3_THEACQ97CM6, TSR3_THEVO
E1QU22, TSR3_VULDIQ12094, TSR3_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-